P2Y12 inhibitors not found to be effective for critically ill patients with COVID-19
Bookmark1. For critically ill patients hospitalized for COVID-19, P2Y12 inhibitors did not improve...
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Emergency
There is substantial variation in the benefit of quality measures in acute stroke care
Bookmark1. In an acute stroke simulation, early carotid imaging and tissue plasminogen activator...
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Characterization of cancer development risk following pediatric radiation exposure from computed tomography
BookmarkEvidence rating level: 3 (Average) 1. Exposure to a higher cumulative number of pediatric...
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Endovascular therapy improved clinical outcomes among patients 6-24 hours post-ischemic stroke with collateral flow
Bookmark1. Median modified Rankin Scale score at 90 days was lower in the endovascular group,...
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Analysis of the role of positive end expiratory pressure for the cannulation of the subclavian vein
Bookmark1. Stepwise changes in positive end expiratory pressure (PEEP) were not associated with...
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Prophylactic tranexamic acid during cesarean section does not lower risk of mortality or transfusion
1. In this randomized controlled trial, prophylactic administration of tranexamic acid during...
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Bempedoic acid reduces the risk of major adverse cardiovascular events
1. In this randomized controlled trial, bempedoic acid significantly reduced low-density...
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Cerebral oximetry monitoring in extremely preterm infants does not reduce mortality
1. In this randomized controlled trial, 72 hours of cerebral oximetry monitoring in preterm...
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Propylthiouracil may be equivocal to methimazole for treatment of thyroid storm
1. In this multi-centre cohort study, there were no significant differences in mortality or...
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Relationship between mean blood pressure and clinical outcome after acute ischemic stroke
1. This retrospective cohort study found a U-shaped relationship between mean SBP and 3-month...
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Endovascular thrombectomy for large ischemic strokes results in improved functional outcomes
1. In this randomized controlled trial, endovascular thrombectomy resulted in better functional...
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Immediate revascularization reduces myocardial infarction rates compared to staged revascularization in multivessel coronary disease
1. The immediate revascularization group met the noninferiority criteria for the primary composite...
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Anakinra likely not effective for patients with severe COVID-19
1. In this randomized trial, in patients with severe COVID-19 pneumonia and biochemical evidence...
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Elevated troponin T levels associated with increased mortality in patients presenting with dyspnea
1. This retrospective study found that in patients presenting to the emergency department with...
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Higher mean arterial pressure targets may be preferable for patients with sepsis
1. In this retrospective cohort study, patients with sepsis and high-mean arterial pressure (MAP)...
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Cardiac arrest survival during delivery lowest in those with disseminated intravascular coagulation
1. In this retrospective cohort study, 68% of female patients with cardiac arrest during their...
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Addition of fludrocortisone to hydrocortisone is beneficial in management of septic shock
1. Patients treated for septic shock with fludrocortisone and hydrocortisone were less likely to...
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72- and 36-hour fever prevention post-cardiac arrest equivalent in preventing mortality
1. In this randomized controlled trial, there was no significant difference in mortality between...
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Over-the-scope clips superior to standard treatment of nonvariceal upper GI bleeding
1. In this randomized controlled trial, over-the-scope clips (OTSCs) reduced the risk of...
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Different variants presenting with different presentations amongst children with COVID-19 infections
1. In children presenting to the emergency department (ED) with a COVID-19 infection, children...
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