LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.
PARP inhibitors induce DNA lesions, the repair of which are highly dependent on homologous...
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Hematology/Oncology
Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction.
Synthetic lethality is a successful strategy employed to develop selective chemotherapeutics...
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Obesity Tied to Increased Mortality Overall in Patients With Cancer
TUESDAY, March 30, 2021 (HealthDay News) — For patients with cancer, obesity is associated...
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First Cell-Based Gene Therapy Approved for Multiple Myeloma
TUESDAY, March 30, 2021 (HealthDay News) — Abecma (idecabtagene vicleucel), a chimeric...
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Outcomes for Complex GI Cancer Surgery Better at Top-Ranked Hospitals
MONDAY, March 29, 2021 (HealthDay News) — For patients who require complex gastrointestinal...
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Actinic Keratosis Diagnosis Ups Cumulative Risk for Skin Cancer
MONDAY, March 29, 2021 (HealthDay News) — The annual increase in risk for cutaneous squamous...
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IRS: COVID-19 PPE Tax-Deductible
MONDAY, March 29, 2021 (HealthDay News) — Faces masks, hand sanitizer, and disinfecting...
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Down-regulation of long non-coding RNA antisense non-coding RNA in the INK4 locus suppresses OVCAR-3 cells proliferation and induction of apoptosis by Wnt/β -catenin.
Ovarian cancer is a lethal gynecological malignancy. Long non-coding RNA antisense non-coding RNA...
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Laparoscopy technique in the setting of peritoneal metastases to avoid port site relapse.
Laparoscopy is indicated in many patients with abdominal and pelvic malignancy. If cancer cells...
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Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
We discovered 6-substituted thieno[2,3-d]pyrimidine compounds (3-9) with 3-4 bridge carbons and...
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2015 to 2018 Saw Decrease in HPV Infections Among Young Women
FRIDAY, March 26, 2021 (HealthDay News) — There have been significant declines in...
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New US Assistant Secretary of Health Is First Openly Transgender Federal Official
THURSDAY, March 25, 2021 (HealthDay News) — Rachel Levine, M.D., has been confirmed by the...
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ACA’s Reach Surges With 200,000 New Signups, More States Involved
TUESDAY, March 23, 2021 (HealthDay News) — More than 200,000 Americans signed up for health...
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ACA’s Reach Surges With 200,000 New Signups, More States Involved
TUESDAY, March 23, 2021 (HealthDay News) — More than 200,000 Americans signed up for health...
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High Anesthesiologist Volume Tied to Better Outcomes for Complex GI Surgical Cases
WEDNESDAY, March 24, 2021 (HealthDay News) — Adults undergoing complex gastrointestinal (GI)...
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Maintenance Therapy Without Steroids Feasible in Elderly Myeloma Patients
WEDNESDAY, March 24, 2021 (HealthDay News) — Dose/schedule-adjusted...
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ENDO: In Utero 17-OHPC Exposure Ups Later Cancer Risk
WEDNESDAY, March 24, 2021 (HealthDay News) — In utero exposure to 17α-hydroxyprogesterone...
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Vivek Murthy Confirmed as New US Surgeon General
WEDNESDAY, March 24, 2021 (HealthDay News) — The COVID-19 pandemic and the opioid overdose...
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Progesterone Receptors Promote Quiescence & Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models.
The ability of ovarian steroids to modify ovarian cancer (OC) risk remains controversial....
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Reporting the trajectories of adverse events over the entire treatment course in patients with recurrent platinum-sensitive ovarian cancer treated with platinum-based combination chemotherapy regimens: A graphical approach to trial adverse event reporting.
Clinical trials report adverse events (AEs) in a dense table focusing on the frequency of...
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