Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.
The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell...
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Hematology/Oncology
Population Screening for Inherited Predisposition to Breast and Ovarian Cancer.
The discovery of genes underlying inherited predisposition to breast and ovarian cancer has...
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Design of Fluorophore Loaded Human Serum Albumin Nanoparticles for Specific Targeting of NIH:OVCAR3 Ovarian Cancer Cells.
Nowadays, extensive research is carried out into finding innovative solutions for the development...
Read MoreMitomycin Gel Gets FDA Nod for Low-Grade Upper Tract Urothelial Tumors
The first non-surgical treatment option for a rare cancer subtype WASHINGTON — Mitomycin gel (Jelmyto), an alkylating drug, is now FDA-approved as the first non-surgical treatment for low-grade upper tract urothelial...
Read MoreSGO: ProMisE-ing Predictions for Progression in Endometrial Ca
Algorithm helps identify which patients can be offered fertility-sparing treatment options Using the Proactive Molecular Classifier for endometrial cancer (ProMisE) algorithm to classify patients with endometrial cancer or...
Read MoreMitomycin Gel Gets FDA Nod for Low-Grade Upper Tract Urothelial Tumors
The first non-surgical treatment option for a rare cancer subtype WASHINGTON — Mitomycin gel (Jelmyto), an alkylating drug, is now FDA-approved as the first non-surgical treatment for low-grade upper tract urothelial...
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A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism.
Ovarian cancer G protein-coupled receptor 1 (OGR1), also known as GPR68, is a proton-sensing G...
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Circulating cell-free DNA (cfDNA) levels in BRCA1 and BRCA2 mutation carriers: A preliminary study.
Female carriers of BRCA1 or BRCA2 germline mutations are at a substantially increased risk for...
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Co-Delivery of Curcumin and Cisplatin to Enhance Cytotoxicity of Cisplatin Using Lipid-Chitosan Hybrid Nanoparticles.
Lipid-polymer hybrid nanoparticles (LPHNP) are suitable for co-delivery of hydrophilic and...
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Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles.
Amine/thiol-reactive chemistries are commonly used to conjugate antibodies to pharmaceuticals or...
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Periprosthetic joint infection of a total hip arthroplasty with Candida parapsilosis.
Fungal periprosthetic joint infection (PJI) is a disruptive and complex complication of joint...
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Long noncoding RNA HOST2, working as a competitive endogenous RNA, promotes STAT3-mediated cell proliferation and migration via decoying of let-7b in triple-negative breast cancer.
Human ovarian cancer specific transcript 2 (HOST2) is a long non-coding RNA (lncRNA) reported to...
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The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positive epithelial ovarian cancer to trastuzumab.
Epithelial ovarian cancer (EOC) is one of the most common and lethal gynecological cancers. Novel...
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Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner.
Small nucleic acid (NA) therapeutics, such as small interfering RNA (siRNA), are generally...
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Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer.
Combination of chemotherapy and gene therapy provides an effective strategy for cancer treatment....
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Risk of breast cancer-related death in women with a prior cancer.
The overall risk of developing a second primary cancer is increasing. The purpose of this study...
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Transcriptional factor Yin Yang 1 facilitates the stemness of ovarian cancer via suppressing miR-99a activity through enhancing its deacetylation level.
The promoting effects of transcriptional factor Yin Yang 1 (YY1) have been confirmed in various...
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A case of primary ovarian signet-ring cell carcinoma treated with S-1/CDDP therapy.
Primary ovarian signet-ring cell carcinoma is extremely rare, with only five recent case reports....
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Ovarian cancer stem cells: ready for prime time?
The role of cancer stem cells (CSC) remains controversial and increasingly subject of...
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Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade.
Immune checkpoint blocking antibodies are currently being tested in ovarian cancer (OC) patients...
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