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Laser Surgery

Spectrum of Disease Severity in Patients With X-Linked Retinitis Pigmentosa Due to RPGR Mutations.

Dec 31, 2020

The purpose of this study was to perform a detailed longitudinal phenotyping of X-linked retinitis pigmentosa (RP) caused by mutations in the RPGR gene during a long follow-up period.An Italian cohort...

Categorisation of myopia progression by change in refractive error and axial elongation and their impact on benefit of myopia control using orthokeratology.

Dec 31, 2020

To compare the value of pre-treatment axial elongation (AE) and changes in refractive sphere (M change) for predicting the success in orthokeratology (ortho-k), in order to better identify suitable ca...

Proteomic analysis of aqueous humor in patients with pathologic myopia.

Dec 31, 2020

Complications from pathologic myopia (PM) are a major cause of visual impairment and blindness. However, an efficient clinical therapeutic strategy for PM is still lacking. The aim of this study was t...

Proposal for the management of myopic traction maculopathy based on the new MTM staging system.

Dec 24, 2020

To propose the Myopic Traction Maculopathy (MTM) management Table, based on the MTM Staging System (MSS).A retrospective review of 157 eyes affected by MTM, operated with pars plana vitrectomy (PPV), ...

A MEWDS-like reaction to concurrent retinal insults.

Dec 24, 2020

To describe a clinical picture resembling classic multiple evanescent white dot syndrome (MEWDS) potentially triggered by previous or concurrent, apparently unrelated, ocular events and to provide a l...

Missense variants in CTNNB1 can be associated with vitreoretinopathy-Seven new cases of CTNNB1-associated neurodevelopmental disorder including a previously unreported retinal phenotype.

Dec 24, 2020

CTNNB1 (MIM 116806) encodes beta-catenin, an adherens junction protein that supports the integrity between layers of epithelial tissue and mediates intercellular signaling. Recently, various heterozyg...

Wavefront excimer laser refractive surgery for adults with refractive errors.

Dec 21, 2020

Refractive errors (conditions in which the eye fails to focus objects accurately on the retina due to defects in the refractive system), are the most common cause of visual impairment. Myopia, hyperop...

Incidence and Outcomes of Suprachoroidal Hemorrhage Following Aurolab Aqueous Drainage Implant in Adult and Pediatric Glaucoma.

Dec 21, 2020

Postoperative suprachoroidal hemorrhage is an infrequent but devastating complication after non-valved aqueous drainage implant surgery and demonstrated a bimodal distribution. The final outcomes of e...

Intravitreal Anti-Vascular Endothelial Growth Factor Injection versus Laser Photocoagulation for Retinopathy of Prematurity: A Meta-Analysis of 3701 Eyes.

Dec 21, 2020

We investigate the efficacy and safety of intravitreal injection (IVI) of anti-vascular endothelial growth factor agents and laser photocoagulation (LPC) for retinopathy of prematurity (ROP). We perfo...

Various cross-linking methods inhibit the collagenase I degradation of rabbit scleral tissue.

Dec 17, 2020

Collagen cross-linking of the sclera is a promising approach to strengthen scleral rigidity and thus to inhibit eye growth in progressive myopia. Additionally, cross-linking might inhibit degrading pr...

Dysfunction of VIPR2 leads to myopia in humans and mice.

Dec 17, 2020

Myopia is the leading cause of refractive errors. As its pathogenesis is poorly understood, we determined if the retinal VIP-VIPR2 signalling pathway axis has a role in controlling signalling output t...

Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic.

Dec 17, 2020

Homocystinuria due to cystathionine β-synthase (CBS) deficiency, the most frequent inborn error of sulfur amino acid metabolism, is characterized biochemically by severely elevated homocysteine (Hcy)...

Individualized Corneal Patching for Treatment of Corneal Trauma Combined with Tissue Defects.

Dec 14, 2020

To evaluate the efficacy of individualized corneal patching using a minimal graft for corneal trauma combined with tissue defects.Fifteen eyes (15 patients) were enrolled in this study, including 8 ey...

Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model.

Dec 14, 2020

In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. Howe...

Combined retinal proteome datasets in response to atropine treatment using iTRAQ and SWATH-MS based proteomics approaches in guinea pig myopia model.

Dec 14, 2020

Atropine, a non-selective muscarinic antagonist, is known to slow down myopia progression in human adolescents and in several animal models. However, its underlying molecular mechanism is unclear. The...

Efficacy and safety of atropine to control myopia progression: a systematic review and meta-analysis.

Dec 10, 2020

The effect and safety of atropine on delaying the progression of myopia has been extensively studied, but its optimal dose is still unclear. Therefore, the purpose of this meta-analysis is to systemat...

Exploring non-adherence to contact lens wear schedule: Subjective assessments and patient related factors in children wearing single vision and myopia control contact lenses.

Dec 10, 2020

To determine factors associated with non-adherence to contact lens wear schedule involving single vision and myopia control contact lenses in children.Data from 379 children enrolled in a prospective,...

Smartphone Overuse and Visual Impairment in Children and Young Adults: Systematic Review and Meta-Analysis.

Dec 10, 2020

Smartphone overuse has been cited as a potentially modifiable risk factor that can result in visual impairment. However, reported associations between smartphone overuse and visual impairment have bee...

Construction of a knowledge graph for diabetes complications from expert-reviewed clinical evidences.

Dec 07, 2020

A knowledge graph is a structured representation of data that can express entity and relational knowledge. More attention has been paid to the study of a clinical knowledge graph, especially in the fi...

Altered Expression of GJD2 Messenger RNA and the Coded Protein Connexin 36 in Negative Lens-induced Myopia of Guinea Pigs.

Dec 07, 2020

Decreased expression of the retinal GJD2 gene messenger RNA (mRNA) and connexin 36 (Cx36) protein in the guinea pig negative lens-induced myopia (LIM) model suggests their involvement in local retinal...

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