Navigating Challenges in HSCT Eligibility for Myelofibrosis
Updated guidelines on allogeneic hematopoietic stem cell transplantation for myelofibrosis examine spleen-related complications, iron overload, and more.
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Myelofibrosis
Model Predicts Progression to Overt Primary Myelofibrosis
: A model for predicting overt primary myelofibrosis survival in those with prefibrotic primary myelofibrosis showed good predictive ability and clinical value.
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Thrombosis in MPN Impact Disease Course, Comorbidities
Thrombosis events in patients with myeloproliferative neoplasms may signal a more aggressive disease course, including myelofibrosis progression and mortality.
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Shear Wave Elastography Beneficial in Diagnosing Myelofibrosis
Shear wave elastography differentiates myelofibrosis from essential thrombocytopenia and polycythemia vera and may help diagnose myeloproliferative neoplasms.
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LOXL2 a Therapeutic Target for Primary Myelofi brosis
Findings from a recent study suggest LOXL2 plays a critical role in the pathogenesis of primary myelofibrosis.
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Low-Risk Myelofibrosis Shows Evidence of Disease Progression
About 60% of patients with low-risk myelofibrosis showed evidence of disease progression during 4 years of follow-up.
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Shear Wave Elastography Distinguishes Myelofibrosis From Other MPNs
Spleen and liver elastography can help diagnose myeloproliferative neoplasms and differentiate myelofibrosis from other myeloproliferative neoplasms.
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AIPSS-MF Plus Next-Generation Sequencing Refines Prognosis & Survival Estimates
Using NGS in prognostic assessments enhances myelofibrosis prognosis and survival estimates, representing a step toward personalized medicine in myelofibrosis.
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Myeloid-Derived Suppressor Cells Associated With Progression
Myeloid-derived suppressor cells are increased in the circulation and in the spleen of patients with primary myelofibrosis and may be new therapeutic targets.
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Sociodemographic Data Helps Estimate Prognosis in Myelofibrosis
The first study to compare national myelofibrosis outcomes with a large minority cohort illustrates links between age, gender, and ethnicity and worse survival.
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Haploidentical, Related, Unrelated: Does Donor Type Impact HTC Outcomes?
Matched sibling donors aside, donor type was not associated with significant differences in overall survival in patients with myelofibrosis who underwent HCT.
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Altered Serum Metabolites in Primary MF Present Opportunities for Antioxidant Therapy
Altered serum metabolites in primary MF present opportunities for antioxidant therapy, as patients with PMF have a different metabolic makeup.
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Analyzing Thrombotic Risk Factors
Recent findings underscore the need for clinicians to stratify arterial and venous thrombosis risks separately in patients with myelofibrosis.
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Triple-Negative Myelofibrosis Shows Aggressive Behavior, Poor Outcomes
Triple-negative myelofibrosis affects 6% of myelofibrosis patients and is marked by aggressive clinical behavior and poor outcomes.
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Anti-T-Lymphocyte Globulin Improves Survival Post-AlloHCT in Patients With Myelofibrosis
Anti-T-lymphocyte globulin significantly reduced the risk of GvHD, relapse, or death by 48%, enhancing GRFS, especially in matched donor transplants.
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Does Splenomegaly Impact Transplant Outcomes?
Splenomegaly did not significantly impact transplant outcomes in patients who underwent hematopoietic stem cell transplantation for myelofibrosis.
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Mutations and Proliferative Pathways Drive Myelofibrosis Evolution
Myeloproliferative neoplasms (MPN) are marked by the overproduction of myeloid cells, driven by...
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