PubMed

MicroRNA-27a transfected dental pulp stem cells undergo odonto/osteogenic differentiation via targeting DKK3 and SOSTDC1 in Wnt/BMP signaling in vitro and enhance bone formation in vivo.

Feb 17, 2025

MicroRNAs (miRNAs) play a crucial role in cell differentiation through epigenetic regulation of gene expression. In human dental pulp cells, we have identified miRNA-27a being upregulated under inflammatory conditions. Here, we...

Vision Restoration through transorbital electrical stimulation in Optic Neuropathy in patients with significant optic atrophy due to primary open-angle glaucoma-a randomised, controlled, double-blind, multicentre clinical trial: the VIRON study protocol.

Feb 17, 2025

Glaucoma is one of the most common causes of blindness and affects more than 70 million people worldwide. The disease is characterised by the loss of retinal ganglion cells associated with a progressive optic neuropathy,...

Predicting visual field global and local parameters from OCT measurements using explainable machine learning.

Feb 17, 2025

Glaucoma is characterised by progressive vision loss due to retinal ganglion cell deterioration, leading to gradual visual field (VF) impairment. The standard VF test may be impractical in some cases, where optical coherence...

Development and validation of MRI-derived deep learning score for non-invasive prediction of PD-L1 expression and prognostic stratification in head and neck squamous cell carcinoma.

Feb 17, 2025

Immunotherapy has revolutionized the treatment landscape for head and neck squamous cell carcinoma (HNSCC) and PD-L1 combined positivity score (CPS) scoring is recommended as a biomarker for immunotherapy. Therefore, this study...

MAGI3 enhances sensitivity to sunitinib in renal cell carcinoma by suppressing the MAS/ERK axis and serves as a prognostic marker.

Feb 17, 2025

Clear cell renal cell carcinoma (ccRCC) exhibits considerable heterogeneity, with approximately 25% of localized cases susceptible to relapse, highlighting the challenge of the absence of reliable predictive biomarkers for...

Machine learning-based identification of co-expressed genes in prostate cancer and CRPC and construction of prognostic models.

Feb 17, 2025

The objective of this study was to employ machine learning to identify shared differentially expressed genes (DEGs) in prostate cancer (PCa) initiation and castration resistance, aiming to establish a robust prognostic model and...

ESCO1 as a novel predictive biomarker and potential therapeutic target in renal cell carcinoma.

Feb 17, 2025

Establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) plays an important role in mitosis and is involved in tumor progression of human bladder and prostate cancer. However, its pathological effects on renal...

CPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells.

Feb 17, 2025

Cancer stem cells (CSCs) play crucial roles in cancer progression, immune evasion, drug resistance, and recurrence. Understanding the mechanisms behind CSCs generation and stemness maintenance is vital for early cancer diagnosis...

Association between plasma cytokine levels and multiple neuroimaging modalities in mild cognitive impairment.

Feb 17, 2025

The relationship between peripheral cytokines and neuroimaging biomarkers for Alzheimer’s disease (AD) is not yet well established.To determine the association of cytokine plasma levels with brain amyloid deposition,...

Cognitive function among methadone assisted treatment patient in Malaysia.

Feb 17, 2025

The use of non-medical opioids has reached 60 million in 2021. Methadone-assisted treatment (MAT) is a widely used harm-reduction strategy for opioid addiction. However, methadone can cause cognitive impairment, which can impede...

Enhanced Alzheimer’s biomarker detection using a ternary composite electrochemical aptasensor.

Feb 17, 2025

The development of a highly sensitive electrochemical aptasensor is reported that combines the unique properties of graphene, metallic oxides, and conducting polymers to overcome the limitations of sensitivity and specificity...

Robust antiviral innate immune response and miRNA regulatory network were identified in ZIKV-infected cells: implications in the pathogenesis of ZIKV infection.

Feb 17, 2025

Zika virus (ZIKV) infection has emerged as a significant public health concern due to its association with fetal microcephaly and Guillain-Barre syndrome (GBS). Unfortunately, its detailed pathogenesis remains unclear. To better...

Experiences of gender-affirming practices in healthcare settings and HIV testing among transgender and nonbinary young adults in the United States.

Feb 17, 2025

Transgender and nonbinary young adults in the United States (U.S.) experience disproportionately high rates of HIV and face unique barriers to accessing HIV testing, a key component of HIV prevention. Gender-affirming practices...

Implications of nociceptor receptors and immune modulation: emerging therapeutic targets for autoimmune diseases.

Feb 17, 2025

Chronic painful autoimmune disorders such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) induce significant discomfort. They are defined by persistent inflammation and immune-mediated...

Biphasic bone loss in experimental autoimmune encephalomyelitis.

Feb 17, 2025

Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS) and a common cause for neurological disabilities in young adults. Although it is known that the peripheral immune landscape is altered...

3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization.

Feb 17, 2025

Fertility preservation following pediatric cancer therapy programs has become a major avenue of infertility research. In vitro spermatogenesis (IVS) aims to generate sperm from banked prepubertal testicular tissues in a lab...

Effect of semaglutide with obesity or overweight individuals without diabetes: an Umbrella review of systematic reviews.

Feb 17, 2025

Summarize the effectiveness and safety of Semaglutide for non-diabetic obese patients through umbrella analysis.From inception to May 2024, we searched PubMed, EMbase, Web of Science, and The Cochrane Library for a systematic...

Clinical Course and Prognosis of Long-Term Survivors of Hepatocellular Carcinoma.

Feb 17, 2025

This study investigated the long-term prognosis and clinical course of patients who survived for more than 5 years after hepatocellular carcinoma (HCC) diagnosis.This retrospective cohort study used data from the Korean National...

Silk Nanofibrillar Aerogel as Sustainable Filters for Environmental Purification.

Feb 17, 2025

Environmental pollution threatens human health and ecosystem sustainability, boosting a huge demand for filters. However, the petroleum-based filters are likewise environmentally hazardous since their non-degradability results...

Risk of allergic diseases in age-related macular degeneration: A nationwide cohort study in South Korea.

Feb 17, 2025

Premorbid allergic diseases are linked with the development of age-related macular degeneration (AMD), however, the risk of allergic diseases among patients with AMD is largely unknown.To evaluate the association between AMD...

Follow Us

PubMed