PubMed

The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1810865 Abstract BACKGROUND Standard first-line therapy for metastatic, squamous non-small-cell lung cancer (NSCLC) is platinum-based chemotherapy or...

The New England journal of medicine 2018 10 01() doi 10.1056/NEJMe1812434 Abstract

Biomedical journal 38(1) 5-8 doi 10.4103/2319-4170.151150 Abstract The first Tang Prize for Biopharmaceutical Science has been awarded to Prof. James P. Allison and Prof. Tasuku Honjo for their contributions leading to an...

The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1809697 Abstract BACKGROUND An earlier analysis in this phase 3 trial showed that durvalumab significantly prolonged progression-free survival, as compared with...

EBioMedicine 2018 09 29() pii 10.1016/j.ebiom.2018.09.015 Abstract BACKGROUND Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated...

The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1810171 Abstract BACKGROUND Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, has robust efficacy in patients with ALK-positive...

Cell reports 25(1) 80-94 pii 10.1016/j.celrep.2018.09.012 Abstract We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood...

Cells 2018 10 017(10) pii 10.3390/cells7100155 Abstract Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably...

Clinical & developmental immunology 2012 03 262012() 485781 doi 10.1155/2012/485781 Abstract The immune system has evolved to allow robust responses against pathogens while avoiding autoimmunity. This is notably enabled by...

Angewandte Chemie (International ed. in English) 2017 11 2857(16) 4143-4148 doi 10.1002/anie.201708408 Abstract Tailor-made: Discussed herein is the ability to adapt biology’s mechanisms for innovation and optimization to...

Proceedings of the National Academy of Sciences of the United States of America 90(12) 5618-22 Abstract Random mutagenesis has been used to engineer the protease subtilisin E to function in a highly nonnatural...

Sports medicine (Auckland, N.Z.) 44 Suppl 2() S175-84 doi 10.1007/s40279-014-0257-8 Abstract Caffeine is a popular work-enhancing supplement that has been actively researched since the 1970s. The majority of research has...

The EMBO journal 11(11) 3887-95 Abstract The classical type of programmed cell death is characterized by its dependence on de novo RNA and protein synthesis and morphological features of apoptosis. We confirmed that stimulated...

Cancer 2012 04 27118(22) 5623-9 doi 10.1002/cncr.27598 Abstract BACKGROUND Completion of the human papillomavirus (HPV) vaccine in a large percentage of young females is an important goal to prevent anogenital cancers associated...

Journal of internal medicine 2012 05 24272(5) 514-5; author reply 516 doi 10.1111/j.1365-2796.2012.02551.x Abstract

Molecular cell 2018 09 21() pii 10.1016/j.molcel.2018.08.020 Abstract Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-driving mutations and translocations. Non-homologous end joining...

Nature communications 2018 07 189(1) 2794 doi 10.1038/s41467-018-05273-7 Abstract Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while...

Bone & joint research 6(7) 399-404 doi 10.1302/2046-3758.67.BJR.2016-0255.R1 Abstract OBJECTIVES The injured anterior cruciate ligament (ACL) is thought to exhibit an impaired healing response, and attempts at surgical...

Nature communications 2018 07 179(1) 2777 doi 10.1038/s41467-018-05245-x Abstract Cas12a (also called Cpf1) is a representative type V-A CRISPR effector RNA-guided DNA endonuclease, which provides an alternative to type II...

Cell reports 24(3) 538-545 pii 10.1016/j.celrep.2018.06.061 Abstract RAD51 promotes homologous recombination repair (HR) of double-strand breaks and acts during DNA replication to facilitate fork reversal and protect nascent DNA...