PubMed

Sports medicine (Auckland, N.Z.) 2018 05 18() doi 10.1007/s40279-018-0938-9 Abstract Ironman triathlons are ultra-endurance events of extreme duration. The performance level of those competing varies dramatically, with elite...

Nature reviews. Cancer 2018 05 21() doi 10.1038/s41568-018-0015-6 Abstract In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric...

Nature 2018 05 16557(7706) 585-589 doi 10.1038/s41586-018-0128-9 Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental cues,...

Nature communications 2018 06 069(1) 2197 doi 10.1038/s41467-018-04564-3 Abstract Eukaryotic cells employ the ribosome-associated quality control complex (RQC) to maintain homeostasis despite defects that cause ribosomes to...

PloS one 2018 06 1813(6) e0198166 doi 10.1371/journal.pone.0198166 Abstract Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP)...

International journal of molecular sciences 2018 06 0619(6) pii 10.3390/ijms19061689 Abstract Parkinson’s disease (PD) is a progressively debilitating neurodegenerative disease characterized by α-synucleinopathy,...

Nature communications 2018 06 089(1) 2231 doi 10.1038/s41467-018-04651-5 Abstract CRISPR advances genome engineering by directing endonuclease sequence specificity with a guide RNA molecule (gRNA). For precisely targeting a gene...

Frontiers in oncology 2018 05 248() 161 doi 10.3389/fonc.2018.00161 Abstract Advances in chemotherapy and targeted therapies have improved survival in cancer patients with an increase of the incidence of newly diagnosed brain...

Journal of hepatology 2018 06 07() pii 10.1016/j.jhep.2018.05.036 Abstract BACKGROUND Nonalcoholic fatty liver disease (NAFLD) with resulting nonalcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis and...

Molecular cell 2018 06 0770(5) 854-867.e9 pii 10.1016/j.molcel.2018.05.001 Abstract RNA binding proteins (RBPs) orchestrate the production, processing, and function of mRNAs. Here, we present the affinity landscapes of 78 human...

The Journal of physiology 2016 06 30594(18) 5329-42 doi 10.1113/JP272453 Abstract KEY POINTS A recent 30 year prospective study showed that lifelong sauna use reduces cardiovascular-related and all-cause mortality; however, the...

eLife 2018 07 037() doi 10.7554/eLife.36402 Abstract Parkinson’s disease is a progressive neuropathological disorder that belongs to the class of synucleopathies, in which the protein alpha-synuclein is found at abnormally...

Genes & development 2018 06 2732(13-14) 929-943 doi 10.1101/gad.313932.118 Abstract While a mutation in is the most common genetic contributor to amyotrophic lateral sclerosis (ALS), much remains to be learned concerning...

The New England journal of medicine 2018 06 25() doi 10.1056/NEJMoa1805233 Abstract Background In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing...

The New England journal of medicine 2018 06 26() doi 10.1056/NEJMoa1716435 Abstract Background The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently...

Cell 2018 06 13() pii 10.1016/j.cell.2018.05.047 Abstract The inner nuclear membrane (INM) encases the genome and is fused with the outer nuclear membrane (ONM) to form the nuclear envelope. The ONM is contiguous with the...

The Journal of clinical investigation 2018 06 26() doi 10.1172/JCI96393 Abstract Dormant or slow-cycling tumour cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery...

Cell 2018 06 12() pii 10.1016/j.cell.2018.05.039 Abstract Many community- and hospital-acquired bacterial infections are caused by antibiotic-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) predisposes...

Nature communications 2018 06 199(1) 2404 doi 10.1038/s41467-018-04495-z Abstract A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive...

The New England journal of medicine 2018 06 13378(25) e34 doi 10.1056/NEJMoa1800389 Abstract BACKGROUND Observational cohort studies and a secondary prevention trial have shown inverse associations between adherence to the...