PubMed

Nature 2018 07 18() doi 10.1038/s41586-018-0324-7 Abstract In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair-which requires a 3′ overhang-and classical non-homologous...

Cancer immunology research 2018 07 20() pii 10.1158/2326-6066.CIR-17-0405 Abstract The success of chimeric antigen receptor (CAR)-mediated immunotherapy in acute lymphoblastic leukemia (ALL) highlights the potential of T-cell...

Nature 2018 07 18() doi 10.1038/s41586-018-0353-2 Abstract Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease. Thermogenic respiration is initiated by...

Cellular and molecular gastroenterology and hepatology 2018 04 126(2) 133-148 doi 10.1016/j.jcmgh.2018.04.003 Abstract Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis....

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 07 19() JCO2017776112 doi 10.1200/JCO.2017.77.6112 Abstract Purpose CPX-351 is a dual-drug liposomal encapsulation of cytarabine...

Nature communications 2018 07 209(1) 2845 doi 10.1038/s41467-018-05049-z Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein...

Nature 559(7714) 336-338 doi 10.1038/d41586-018-05679-9 Abstract

Nature 2018 07 18() doi 10.1038/s41586-018-0342-5 Abstract Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours,...

Science translational medicine 10(450) pii 10.1126/scitranslmed.aar3342 Abstract Combination anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) and anti-programmed cell death protein 1 (PD-1) therapy promotes antitumor immunity and...

Nature methods 2018 07 16() doi 10.1038/s41592-018-0048-5 Abstract The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its...

Nature communications 2018 06 309(1) 2447 doi 10.1038/s41467-018-04907-0 Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for...

eLife 2018 07 037() doi 10.7554/eLife.36402 Abstract Parkinson’s disease is a progressive neuropathological disorder that belongs to the class of synucleopathies, in which the protein alpha-synuclein is found at abnormally...

Genes & development 2018 06 2732(13-14) 929-943 doi 10.1101/gad.313932.118 Abstract While a mutation in is the most common genetic contributor to amyotrophic lateral sclerosis (ALS), much remains to be learned concerning...

The New England journal of medicine 2018 06 25() doi 10.1056/NEJMoa1805233 Abstract Background In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing...

The New England journal of medicine 2018 06 26() doi 10.1056/NEJMoa1716435 Abstract Background The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently...

Cell 2018 06 13() pii 10.1016/j.cell.2018.05.047 Abstract The inner nuclear membrane (INM) encases the genome and is fused with the outer nuclear membrane (ONM) to form the nuclear envelope. The ONM is contiguous with the...

The Journal of clinical investigation 2018 06 26() doi 10.1172/JCI96393 Abstract Dormant or slow-cycling tumour cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery...

Cell 2018 06 12() pii 10.1016/j.cell.2018.05.039 Abstract Many community- and hospital-acquired bacterial infections are caused by antibiotic-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) predisposes...

The New England journal of medicine 2018 06 13378(25) 2441-2442 doi 10.1056/NEJMc1806491 Abstract

Cell 2018 06 09() pii 10.1016/j.cell.2018.05.057 Abstract The diversity of cell types and regulatory states in the brain, and how these change during aging, remains largely unknown. We present a single-cell transcriptome atlas...