PubMed

Nature 2018 06 06558(7708) 73-79 doi 10.1038/s41586-018-0175-2 Abstract Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control...

Nature communications 2018 06 069(1) 2197 doi 10.1038/s41467-018-04564-3 Abstract Eukaryotic cells employ the ribosome-associated quality control complex (RQC) to maintain homeostasis despite defects that cause ribosomes to...

Blood 2018 06 08() pii 10.1182/blood-2018-03-840132 Abstract Understanding the profile of oncogene and tumor suppressor gene mutations with their interactions and impact on the prognosis of multiple myeloma (MM) can improve the...

Journal of cognitive neuroscience 2018 06 07() 1-26 doi 10.1162/jocn_a_01291 Abstract The prefrontal cortex (pFC) is central to flexible, goal-directed cognition, and understanding its representational code is an important...

Brain : a journal of neurology 2018 06 05() doi 10.1093/brain/awy146 Abstract Lewy bodies commonly occur in Alzheimer’s disease, and Alzheimer’s disease pathology is frequent in Lewy body diseases, but the burden of...

Nature 2018 06 06() doi 10.1038/s41586-018-0190-3 Abstract Wnt-β-catenin signalling plays a pivotal role in the homeostasis of the intestinal epithelium by promoting stem cell renewal. In the small intestine, epithelial Paneth...

Current opinion in genetics & development 2018 06 0452() 48-56 pii 10.1016/j.gde.2018.05.005 Abstract Genome editing with engineered nucleases (zinc finger, TAL effector, or CRISPR/Cas9-based) enables `write’ access...

Nucleic acids research 2018 06 07() doi 10.1093/nar/gky505 Abstract Genome editing technology based on engineered nucleases has been increasingly applied for targeted modification of genes in a variety of cell types and...

Clinical pediatrics 30(7) 441-5 Abstract Test anxiety is severely disabling to students whose fear of examinations causes cognitive dysfunction that paralyzes their thinking the way stage fright impairs actors ability to act. In...

Scientific reports 2018 05 258(1) 8171 doi 10.1038/s41598-018-25837-3 Abstract Macrophages (MΦs) are involved in folliculogenesis and ovulation. However, it is unknown which type of MΦ, M1 or M2, plays a more essential role in...

Nature 2018 05 21558(7708) 95-99 doi 10.1038/s41586-018-0143-x Abstract The Peltier effect, discovered in 1834, converts a charge current into a heat current in a conductor, and its performance is described by the Peltier...

Cell 2018 05 11() pii 10.1016/j.cell.2018.04.028 Abstract Degrons are minimal elements that mediate the interaction of proteins with degradation machineries to promote proteolysis. Despite their central role in proteostasis, the...

Nature 2018 05 16557(7707) 724-728 doi 10.1038/s41586-018-0119-x Abstract Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS). Microglia modulate pro-inflammatory and...

Nature 2018 05 16557(7706) 575-579 doi 10.1038/s41586-018-0130-2 Abstract Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving to be effective at restoring T cell-mediated immune responses that...

Sports medicine (Auckland, N.Z.) 2018 05 18() doi 10.1007/s40279-018-0938-9 Abstract Ironman triathlons are ultra-endurance events of extreme duration. The performance level of those competing varies dramatically, with elite...

Nature reviews. Cancer 2018 05 21() doi 10.1038/s41568-018-0015-6 Abstract In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric...

Nature 2018 05 16557(7706) 585-589 doi 10.1038/s41586-018-0128-9 Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental cues,...

Nature communications 2018 06 069(1) 2197 doi 10.1038/s41467-018-04564-3 Abstract Eukaryotic cells employ the ribosome-associated quality control complex (RQC) to maintain homeostasis despite defects that cause ribosomes to...

PloS one 2018 06 1813(6) e0198166 doi 10.1371/journal.pone.0198166 Abstract Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP)...

International journal of molecular sciences 2018 06 0619(6) pii 10.3390/ijms19061689 Abstract Parkinson’s disease (PD) is a progressively debilitating neurodegenerative disease characterized by α-synucleinopathy,...