PubMed

Fear of hypoglycemia relates to glycemic levels during and after real-world physical activity in adolescents with type 1 diabetes.

Dec 9, 2024

We explore the association between hypoglycaemia fear (FH) and glycaemia during and after exercise sessions in a large sample of physically active youth with type 1 diabetes (T1D).We used data from the Type 1 Diabetes Exercise...

Clinical utility of liver function tests for resolution of metabolic dysfunction-associated steatotic liver disease after weight loss in the Diabetes Remission Clinical Trial.

Dec 9, 2024

Ectopic fat is reduced by effective weight management, but difficult to assess clinically.We evaluated paired data on 42 participants in the intervention group of the Diabetes Remission Clinical Trial (DiRECT) at baseline, 12...

Repurposed drugs as PCSK9-LDLR disruptors for lipid lowering and cardiovascular disease therapeutics.

Dec 9, 2024

The PCSK9 protein binds to LDL receptors (LDLR), leading to their degradation and reduced expression on cell surfaces. This decreased the clearance of LDL cholesterol from the bloodstream, thereby increasing the risk of coronary...

Loss of pulmonary capillaries in idiopathic pulmonary arterial hypertension with low diffusion capacity is accompanied by early diffuse emphysema detected by Xe MRI.

Dec 9, 2024

Recent studies suggest the existence of an idiopathic pulmonary arterial hypertension (IPAH) phenotype affecting mostly patients with a smoking history, characterised by low diffusion capacity for carbon monoxide (D) without...

The risk of childhood asthma across diverse climates: growing up in Australia.

Dec 9, 2024

This study investigates the association between climate and childhood asthma in Australia. Data from the Longitudinal Study of Australian Children (LSAC) was used to analyse this association in children who were 6-15 years...

Evaluation of Metastasis Inhibition by ABD-IL-2 Compared to Human IL-2 in a Breast Cancer Mouse Model.

Dec 9, 2024

Interleukin-2 (IL-2) is a well-known cytokine that plays a crucial role in stimulating immune cells, including natural killer (NK) cells and cytotoxic T cells. It has been studied as an immunotherapy for a variety of diseases,...

Treatment of Delayed Hypersensitivity After Injection of Nasal Fillers.

Dec 9, 2024

Soft tissue filler injection is the second most commonly performed cosmetic procedure worldwide, with augmentation rhinoplasty being the most common filling surgery in Asian countries because Asians predominantly have a low...

Web-based cognitive screening in bipolar disorder: validation of the Internet-based Cognitive Assessment Tool in remote administration settings.

Dec 2, 2024

Cognitive impairments are prevalent during remission in bipolar disorder (BD), but existing cognitive screening tools are time- and resource-intensive. Digital, web-based options can facilitate detection and monitoring of these...

Toward harmonization of aging and technology research: German adaptation of the mobile device proficiency questionnaire (MDPQ) for older adults.

Dec 2, 2024

The Mobile Device Proficiency Questionnaire (MDPQ) is a well-established, reliable, and valid instrument to measure basic and advanced mobile device skills among older adults. We offer a German adaptation of the MDPQ and report...

vNOTES chromopertubation: a new method for assessing tubal patency and peritubal anatomy.

Dec 2, 2024

We conducted a retrospective cohort study of women with suspected tubal factor infertility who underwent vaginal natural orifice endoluminal surgery (vNOTES) chromopertubation and adnexal anatomy assessment at a large referral...

Comparing talent development environments of girls and boys in handball and ice hockey in Norway.

Dec 2, 2024

Currently, there is little research on successful talent development environments (TDEs) focusing on women and girls. In response, the main aim of the present study was to compare TDEs of age-specific national teams for girls...

Efficacy of a thermoplastic mask and pneumatic abdominal compression device for immobilization in stereotactic ablative radiotherapy of spine metastases.

Dec 2, 2024

Stereotactic ablative radiotherapy (SABR) has become a key technique in management of spine metastases. With improved control over treatment plan dosimetry, there is a greater need for accurate patient positioning to guarantee...

Microcirculatory parameters as risk factors for predicting progression of posterior staphyloma in highly myopic eyes: a case-control study.

Dec 2, 2024

To assess the rate of macular blood flow decreasing in adults with and without posterior staphyloma (PS) using optical coherence tomography angiography (OCTA) and to identify risk factors associated with PS progression.This...

Evaluating the Prognostic Impact of Apparent Diffusion Coefficient in Definitive Radiotherapy for Gleason Score 7 Prostate Cancer Patients.

Dec 2, 2024

To investigate the utility of diffusion-weighted magnetic resonance imaging (DW-MRI) in evaluating Gleason score (GS) 7 tumors before definitive radiotherapy (RT) and to explore its association with clinicopathological factors...

Evaluating the dosimetric impact of deep-learning-based auto-segmentation in prostate cancer radiotherapy: Insights into real-world clinical implementation and inter-observer variability.

Dec 2, 2024

This study aimed to investigate the dosimetric impact of deep-learning-based auto-contouring for clinical target volume (CTV) and organs at risk (OARs) delineation in prostate cancer radiotherapy planning. Additionally, we...

Treatment of metastatic breast cancer by stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS).

Dec 2, 2024

The role of local ablative radiotherapy (stereotactic body radiotherapy (SBRT)/stereotactic radiosurgery (SRS)) in the management of metastatic breast cancer (mBC) patients remains unclear. This study aimed to assess the...

Preliminary clinical evaluation of the treatment efficacy of a temperature-adjustable cryotherapy device for chronic, recurrent blepharitis in dogs.

Dec 2, 2024

To preliminarily evaluate the treatment efficacy of a temperature-adjustable cryotherapy device for chronic, recurrent blepharitis in dogs.Five dogs (eight eyes) of different breeds with blepharitis, which was unresponsive to...

Cost-effectiveness of clobazam as an adjunctive treatment for refractory epilepsy in China.

Dec 2, 2024

Clobazam (CLB) is an effective, safe and well-tolerated adjunctive treatment for refractory epilepsy. However, the cost-effectiveness of CLB in China remains unclear.The aim of this study was to evaluate the cost-effectiveness...

Opioid use and poisoning in hospitalized patients with chronic kidney disease.

Dec 2, 2024

Identifying factors associated with uncomplicated and complicated opioid use is essential, especially with regard to safety concerns in impaired kidney function. Literature about opioid prescription and their potential...

Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society-USA Panel.

Dec 2, 2024

New data and new antiretroviral drugs and formulations continue to become available for the prevention and management of HIV infection.To provide updated recommendations for HIV treatment and clinical management and HIV...

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