PubMed

Direct oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation and stage 5 chronic kidney disease under dialysis: A systematic review and meta-analysis of randomized controlled trials.

Jan 29, 2024

In patients with atrial fibrillation (AF) and normal or slightly impaired renal function, the use of direct oral anticoagulants (DOACs) is preferable to vitamin K antagonists (VKAs). However, in patients undergoing hemodialysis,...

Minimally invasive surgery for esophagogastric junction cancer with Leriche’s syndrome-induced ischemic enteritis in the rectum: A case report.

Jan 29, 2024

The incidence of esophagogastric junction cancer has been increasing, leading to growing interest in surgical treatment. Leriche syndrome, characterized by occlusion limited to the infrarenal aorta, has not been reported to be...

Advances in endotoxin analysis.

Jan 29, 2024

The outer membrane of gram-negative bacteria is primarily composed of lipopolysaccharide (LPS). In addition to protection, LPS defines the distinct serogroups used to identify bacteria specifically. Furthermore, LPS also act as...

Exploration and validation of signature genes and immune associations in septic cardiomyopathy.

Jan 29, 2024

An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis of sepsis. In our research, we aimed to identify signature genes and their immune connections in septic cardiomyopathy. By...

Risk factors and predicting nomogram for the clinical deterioration of non-severe community-acquired pneumonia.

Jan 29, 2024

Currently, there remains insufficient focus on non-severe community-acquired pneumonia (CAP) patients who are at risk of clinical deterioration, and there is also a dearth of research on the related risk factors. Early...

Diagnosis and management of complications following pelvic organ prolapse surgery using a synthetic mesh: French national guidelines for clinical practice.

Jan 29, 2024

Complications associated with pelvic organ prolapse (POP) surgery using a synthetic non-absorbable mesh are uncommon (<5%) but may be severe and may hugely diminish the quality of life of some women. In drawing up these...

Knowledge, Attitudes, Practices and Perceived Challenges for Healthcare Workers on Water-Less ICU Care at a Neonatal Intensive Care Unit in Singapore.

Jan 29, 2024

Implementation of water-less care, including removal of sinks from patient care areas, is an emerging approach to reduce water-borne infections in high-risk areas such as intensive care units (ICUs). This approach, however,...

A retrospective analysis of concussion and post-concussional syndrome diagnoses in Western Australian emergency departments.

Jan 29, 2024

To determine the rate of concussion diagnoses per capita recorded in hospital emergency departments in Western Australia (WA) from 2002-2018 for ICD-10-AM concussion diagnoses S06.00-S06.05, and post-concussional syndrome (PCS)...

Firearm storage practices among military veterans in the United States: Findings from a nationally representative survey.

Jan 29, 2024

Unsafe storage of firearms is associated with heightened risk of suicide among veterans. However, contemporary population-based data on the prevalence and correlates of firearm storage practices among veterans are limited.Data...

D-ribose metabolic disorder and diabetes mellitus.

Jan 29, 2024

D-ribose, an ubiquitous pentose compound found in all living cells, serves as a vital constituent of numerous essential biomolecules, including RNA, nucleotides, and riboflavin. It plays a crucial role in various fundamental...

PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition.

Jan 29, 2024

Doxorubicin (DOX) is an anthracycline antibiotic used as an antitumor treatment. However, its clinical application is limited due to severe side effects such as cardiotoxicity. In recent years, numerous studies have demonstrated...

Oral anticoagulant safety in family practice: prognostic accuracy of Bleeding Risk Scores (from the CACAO study).

Jan 29, 2024

To assess bleeding risk of patients treated by oral anticoagulants, several scores have been constructed to assist physicians in the evaluation of the benefit risk. Most of these scores lack a strong enough level of evidence for...

Prospective analysis of pre and postoperative laboratory parameters associated with thrombosis in patients with ovarian cancer.

Jan 29, 2024

Patients with ovarian cancer have a high risk of developing thrombosis. We aimed to investigate pre and post operative biomarkers associated with thrombosis including deep vein thrombosis and pulmonary thromboembolism in...

Prevalence of Guideline Discordant Aspirin use and Associated Adverse Events in Patients on Warfarin for Mechanical Valve Replacement.

Jan 29, 2024

For patients on warfarin for mechanical heart valve replacement, the 2020 American College of Cardiology and American Heart Association Guidelines recommend only adding aspirin in patients with a specific indication for...

Anticoagulant prescribing patterns in patients with primary central nervous system malignancies and secondary metastases.

Jan 29, 2024

To evaluate the safety of direct oral anticoagulants (DOACs) versus low-molecular weight heparin (LMWH) in patients with central nervous system (CNS) malignancies and secondary metastases. All adult patients with CNS...

Quantifying the Benefit-Risk Trade-Off for Individual Patients in a Clinical Trial: Principles and Anti-Thrombotic Case Study.

Jan 29, 2024

A treatment’s overall favourable benefit-risk profile does not imply that every individual patient will benefit from the treatment. We describe a statistical methodology for quantifying the benefit-risk trade-off in...

Bayesian Mendelian randomization with an interval causal null hypothesis: ternary decision rules and loss function calibration.

Jan 29, 2024

We enhance the Bayesian Mendelian Randomization (MR) framework of Berzuini et al. (Biostatistics 21(1):86-101, 2018) by allowing for interval null causal hypotheses, where values of the causal effect parameter that fall within a...

Association between dietary diversity and chronic kidney disease in community-dwelling older adults.

Jan 29, 2024

The present study examined whether dietary diversity is associated with chronic kidney disease (CKD) in community-dwelling older Japanese adults.Participants comprised 8,195 older adults (mean age was 74.0 ± 5.6 years; 42.7%...

Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results.

Jan 29, 2024

The aim of this sub-study was to evaluate the relationship between echocardiography (echo) and cardiac magnetic resonance imaging (cMRI) variables and to utilize echo to assess the effect of macitentan on right ventricle (RV)...

Is catheter ablation associated with preservation of cognitive function? An analysis from the SAGE-AF observational cohort study.

Jan 29, 2024

To examine the associations between catheter ablation treatment (CA) vs. medical management and cognitive impairment among older adults with atrial fibrillation (AF).Ambulatory patients who had AF, were ≥65-years-old, and were...

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