PubMed

Combined cystoscopic-abdominal vs. abdominal only route for complete excision of large deep endometriosis nodules infiltrating the supratrigonal area of the bladder: a comparative study.

Jan 22, 2024

Surgical excision of large deep endometriosis nodules infiltrating the bladder may be challenging, particularly when the nodule limits are close to the trigone and ureteral orifice. Bladder nodules have classically been...

Transforming growth factor-induced gene TGFBI is correlated with the prognosis and immune infiltrations of breast cancer.

Jan 22, 2024

Transforming growth factor β (TGFβ) is a critical regulator of lung metastasis of breast cancer and is correlated with the prognosis of breast cancer. However, not all TGFβ stimulated genes were functional and prognostic in...

circNINL facilitates aerobic glycolysis, proliferation, invasion, and migration in lung cancer by sponging miR-3918 to mediate FGFR1 expression.

Jan 22, 2024

Previously characterized as an oncogenic player in breast cancer, the function of circular RNA NINL (circNINL) in lung cancer (LC) remained elusive. This study aimed to delineate the biological role of circNINL in LC and to...

Computational Phenotyping of OMOP CDM Normalized EHR for Prenatal and Postpartum Episodes: An Informatics Framework and Clinical Implementation on All of Us.

Jan 22, 2024

The use of Electronic Health Records (EHR) in pregnancy care and obstetrics-gynecology (OB/GYN) research has increased in recent years. In pregnancy, timing is important because clinical characteristics, risks, and patient...

Bidirectional associations between sleep problems and suicidal thought/attempt in adolescents: A 3-wave data path analysis.

Jan 22, 2024

This longitudinal data analysis examined the bidirectional relationships between sleep problems and suicidal thought (ST)/attempt (SA) in a large sample of Chinse adolescents.A total of 6995 adolescents (mean age = 14.86 years...

Causal association between sleep traits and autoimmune arthritis: Evidence from a bidirectional Mendelian randomization study.

Jan 22, 2024

To explore whether there is a genetic causal relationship between sleep traits and the risk of autoimmune arthritis (AA).Univariable and multivariable Mendelian randomization was employed using genome-wide association studies...

EPITRANS. Quality assessment of the epilepsy transition process.

Jan 22, 2024

To analyze the differences in clinical management during the epilepsy transition process from pediatric to adult care and to determine the quality of life and degree of satisfaction of patients and caregivers during the...

Early-stage idiopathic Parkinson’s disease is associated with reduced circular RNA expression.

Jan 22, 2024

Neurodegeneration in Parkinson’s disease (PD) precedes diagnosis by years. Early neurodegeneration may be reflected in RNA levels and measurable as a biomarker. Here, we present the largest quantification of whole blood...

The effect of acupuncture on exercise capacity in patients with COPD is mediated by improvements of dyspnea and leg fatigue: a causal mediation analysis using data from a randomized controlled trial.

Jan 22, 2024

Acupuncture is known to improve exercise capacity in patients with chronic obstructive pulmonary disease (COPD), but its mechanism remains unknown. Whether acupuncture improves exercise capacity in patients with COPD through...

Causal relationship between multiple sclerosis and cortical structure: a Mendelian randomization study.

Jan 22, 2024

Observational studies have suggested an association between multiple sclerosis (MS) and cortical structure, but the results have been inconsistent.We used two-sample Mendelian randomization (MR) to assess the causal relationship...

The mechanism by which cannabidiol (CBD) suppresses TNF-α secretion involves inappropriate localization of TNF-α converting enzyme (TACE).

Jan 22, 2024

Cannabidiol (CBD) is a phytocannabinoid derived from Cannabis sativa that exerts anti-inflammatory mechanisms. CBD is being examined for its putative effects on the neuroinflammatory disease, multiple sclerosis (MS). One of the...

Interaction between diabetes and body mass index on severe headache or migraine in adults: a cross-sectional study.

Jan 22, 2024

Research on the effects of body mass index (BMI) on severe headache or migraine is limited and controversial. The aim of this study was to explore the association between BMI and the prevalence of migraine, with particular...

Effect of different non-pharmacologic placebo treatments on migraine prevention: a network meta-analysis of randomized controlled trials.

Jan 22, 2024

Placebo control plays an important role in evaluating the effectiveness of interventions. Specifying differential effects of various placebo controls on migraine prevention would be essential in the explanation of preventive...

Individualized monitoring of longitudinal heading exposure in soccer.

Jan 22, 2024

There is growing concern that repetitive soccer headers may have negative long-term consequences on brain health. However, inconsistent and low-quality heading exposure measurements limit past investigations of this effect. Here...

Patterns of comorbidities differentially affect long-term functional evolution and disease activity in patients with ‘difficult to treat’ rheumatoid arthritis.

Jan 22, 2024

Characterisation of the long-term outcome of patients with ‘difficult to treat’ (D2T) rheumatoid arthritis and factors contributing to its evolution are unknown. Herein, we explored the heterogeneity and contributing...

Effects of exercise-based interventions on inflammatory markers in patients with fibromyalgia: A systematic review and meta-analysis.

Jan 22, 2024

The aim of the present review was (1) to determine the effects of exercise based-interventions (EBIs) on pro-inflammatory and anti-inflammatory biomarkers in patients with fibromyalgia (FM), and (2) to determine the most...

Histone deacetylase inhibitors VPA and WT161 ameliorate the pathological features and cognitive impairments of the APP/PS1 Alzheimer’s disease mouse model by regulating the expression of APP secretases.

Jan 22, 2024

Alzheimer’s disease (AD) is a degenerative neurological disorder. Recent studies have indicated that histone deacetylases (HDACs) are among the most prominent epigenetic therapy targets and that HDAC inhibitors have...

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution.

Jan 22, 2024

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the substantia nigra...

Sibling Relationships in Families of Autistic and Typical Children: Similarities and Differences in the Perspectives of Siblings and Mothers.

Jan 22, 2024

This study investigates mothers’ and siblings’ perspectives regarding similarities and differences in siblingships with and without autism. Twenty-nine typical children (M = 8.78 years, SD = 2.05) whose younger...

Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study.

Jan 22, 2024

Emerging evidence reveals associations between metabolic syndrome (MetS) and psychiatric disorders (PDs), although causality remains uncertain. Consequently, we conducted Mendelian randomization (MR) to systematically evaluate...

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