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OB/GYN General

Next-generation sequencing based deep learning model for prediction of HER2 status and response to HER2-targeted neoadjuvant chemotherapy.

Feb 10, 2025

For patients with breast cancer, the amplification of Human Epidermal Growth Factor 2 (HER2) is closely related to their prognosis and treatment decisions. This study aimed to further improve the acc...

Exposure of pregnant and lactating parental mice to aflatoxin B promotes hepatotoxicity in offspring mice.

Feb 03, 2025

Aflatoxin B1 (AFB) taints feeds stuffs, endangering livestock's health and resulting in the liver and breast damage. At the same time, while breastfeeding, AFB crosses the mammary glands and enters th...

SHP2 regulates the HIF-1 signaling pathway in the decidual human endometrial stromal cells.

Feb 03, 2025

The decidual endometrial stromal cells play a critical role in the establishment of uterine receptivity and pregnancy in human. Our previous studies demonstrate that protein tyrosine phosphatase 2 SHP...

The impact of breast surgery and systemic therapy on the survival of patients with de novo stage IV breast cancer.

Feb 03, 2025

Systemic therapy (ST) is essential for de novo stage IV breast cancer (BC). Stage IV BCs are highly heterogeneous, and it seems inappropriate to treat all de novo stage IV BCs equally. The survival be...

Clinical and molecular analysis of ESBL, carbapenemase, and colistin-resistant bacteria in UTI patients.

Jan 13, 2025

Uropathogens, particularly bacteria, can infect any part of the urinary tract and cause bacteriuria. Our study aimed to examine the antibiotic-resistant profile, associated risk factors, and phenotypi...

Assessment of bacteriological and immunological markers in urinary tract infection and the effect of antibiotics on the isolated bacteria.

Jan 13, 2025

Urinary tract infections (UTIs) are recognized as the second most common medical condition, following respiratory infections. Despite the availability of numerous efficacious antibiotics for the manag...

Investigating intrauterine exposure to methamphetamine on serine-threonine kinase pathway in male rat testis.

Jan 13, 2025

Today, methamphetamine (METH) is being used by adolescents and young adults. Our previous research demonstrated that intrauterine exposure to METH induces apoptosis in testicles and seminiferous tubes...

The prognostic value of changes in Ki67 following neoadjuvant chemotherapy in residual triple-negative breast cancer: a Swedish nationwide registry-based study.

Jan 13, 2025

To evaluate the prognostic significance of changes in pre- and post-neoadjuvant chemotherapy (NACT) Ki67 in patients with primary invasive triple-negative breast cancer (TNBC).Population-based registr...

Controlled Inflammation Drives Neutrophil-Mediated Precision Drug Delivery in Heterogeneous Tumors.

Jan 13, 2025

Tumor heterogeneity remains a formidable obstacle in targeted cancer therapy, often leading to suboptimal treatment outcomes. This study presents an innovative approach that harnesses controlled infla...

Frequency of somatic and germline variants of predisposition genes in young Chinese women with breast cancer.

Jan 06, 2025

Age stratification influences the clinicopathological features and survival outcomes of breast cancer. We aimed to understand the effect of age on gene variants in young Chinese women with breast canc...

Comparing combined paravaginal repair with pubocervical fascia plication versus standard anterior colporrhaphy for the treatment of stress urinary incontinence in women with anterior vaginal wall prolapse: a randomised controlled trial.

Dec 30, 2024

Stress urinary incontinence (SUI) is prevalent among women, often occurring alongside anterior vaginal wall prolapse. This study compares the efficacy and safety of an improved vaginal wall repair tec...

Unsupervised clustering analysis of treatment strategies for elite female athletes with severe stress urinary incontinence: focusing on competition return and SUI improvement.

Dec 30, 2024

To evaluate two primary outcomes in elite female athletes (EFAs) with severe stress urinary incontinence (SUI) 24 months post-intervention: return to elite-level competition and improvement in SUI sy...

Effect of maternal exposure to antibiotics during pregnancy on the neonatal intestinal microbiome and health.

Dec 23, 2024

Antibiotics are widely used during pregnancy. Recent epidemiological studies suggest that maternal exposure to antibiotics during pregnancy is associated with increased risks of various diseases in of...

OsPAD1, encoding a non-specific lipid transfer protein, is required for rice pollen aperture formation.

Dec 23, 2024

Plant lipid transfer proteins (LTPs) are distinguished by their capacity to facilitate lipid transport in vitro between membranes. This includes the transportation of lipid constituents from the tapet...

An R2R3-type MYB transcription factor, GmMYB77, negatively regulates isoflavone accumulation in soybean [Glycine max (L.) Merr.].

Dec 09, 2024

Soybean [Glycine max (L.) Merr.] is an exceptionally rich in isoflavones, and these compounds attach to oestrogen receptors in the human body, lessening the risk of breast cancer and effectively allev...

Integration of Longitudinal and Transverse Radiomics from Ultrasound Images with Clinical Factors for HER-2 Status Prediction in Invasive Breast Cancer Patients.

Dec 09, 2024

This study developed a nomogram combining longitudinal and transverse ultrasound radiomics with clinical factors to identify human epidermal growth factor receptor 2 (HER2) status in invasive breast c...

Treatment of metastatic breast cancer by stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS).

Dec 02, 2024

The role of local ablative radiotherapy (stereotactic body radiotherapy (SBRT)/stereotactic radiosurgery (SRS)) in the management of metastatic breast cancer (mBC) patients remains unclear. This study...

Knowledge of pelvic floor muscles in community-dwelling women aged over 60: its relationship with urinary incontinence.

Nov 04, 2024

To investigate the awareness of the pelvic floor muscles (PFMs) and PFM exercises (PFME) knowledge, training and experience in community-dwelling women aged 60 and over and its relationship with urina...

Targeting the SPC25/RIOK1/MYH9 Axis to Overcome Tumor Stemness and Platinum Resistance in Epithelial Ovarian Cancer.

Nov 04, 2024

In epithelial ovarian cancer (EOC), platinum resistance, potentially mediated by cancer stem cells (CSCs), often leads to relapse and treatment failure. Here, the role of spindle pole body component 2...

Fear of the Cancer Coming Back: A Metasynthesis of Fear of Recurrence in Breast Cancer.

Nov 04, 2024

This review aimed to consolidate existing knowledge on this phenomenon by incorporating direct testimonies from individuals who have experienced breast cancer.A thorough metasynthesis of qualitative s...

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