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OB/GYN General

Population Screening for Inherited Predisposition to Breast and Ovarian Cancer.

Apr 22, 2020

The discovery of genes underlying inherited predisposition to breast and ovarian cancer has revolutionized the ability to identify women at high risk for these diseases before they become affected. Wo...

Design of Fluorophore Loaded Human Serum Albumin Nanoparticles for Specific Targeting of NIH:OVCAR3 Ovarian Cancer Cells.

Apr 22, 2020

Nowadays, extensive research is carried out into finding innovative solutions for the development of stable, reproductible and highly efficient fluorescent contrast agents having the ability of target...

Circulating plasma metabolites and risk of rheumatoid arthritis in the Nurses' Health Study.

Apr 22, 2020

RA develops slowly over years. We tested for metabolic changes prior to RA onset using a large non-targeted metabolomics platform to identify novel pathways and advance understanding of RA development...

Fluorescence and Multiphoton Imaging for Tissue Characterization of a Model of Postmenopausal Ovarian Cancer.

Apr 22, 2020

To determine the efficacy of targeted fluorescent biomarkers and multiphoton imaging to characterize early changes in ovarian tissue with the onset of cancer.A transgenic TgMISIIR-TAg mouse was used a...

17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.

Apr 22, 2020

Aging effects in energy balance in all tissues and organs, including the cardiovascular. The risk of cardiovascular disease is drastically higher in postmenopausal women than in premenopausal women. E...

Anti-osteoporotic effects of Salvia miltiorrhiza Bunge EtOH extract both in ovariectomized and naturally menopausal mouse models.

Apr 22, 2020

Salvia miltiorrhiza is a traditional oriental medicine widely used for preventing and treating disorders of the liver, menstrual, and blood circulation systems. Osteoporosis, loss of bone with age and...

Blood Vitronectin Induces Detrimental Brain Interleukin-6 and Correlates With Outcomes After Stroke Only in Female Mice.

Apr 22, 2020

Background and Purpose- Women have worse stroke outcomes than men, especially after menopause. Few studies have focused on female-specific mechanisms, other than hormones. We investigated the role of ...

The prevalence of anxiety symptoms in infertile women: a systematic review and meta-analysis.

Apr 22, 2020

Infertile women are exposed more frequently to anxiety risk than are infertile men, thereby adversely affecting the procedures with which they are treated and the quality of their lives. Yet, this pro...

Investigation of the association of endothelial nitric oxide synthase (eNOS)-T786C gene polymorphism with the risk of male infertility in an Iranian population.

Apr 22, 2020

Recent studies have demonstrated that making the sorts of oxygen reactive, such as nitric oxide, can cause oxidative lipid damage, protein damage, and damage to the DNA of cells. Sperm DNA damage effe...

Neudesin: a neuropeptide hormone decreased in subjects with polycystic ovary syndrome.

Apr 22, 2020

Neudesin is a neuropeptide hormone involves in female reproduction system via promoting effects of progesterone. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder associated wi...

Association of decreased myonectin levels with metabolic and hormonal disturbance in polycystic ovary syndrome.

Apr 22, 2020

Myonectin is a myokine involving in glucose and lipid metabolisms. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder associated with insulin resistance. Our aims were to discov...

Axillary Nodal Evaluation in Breast Cancer: State of the Art.

Apr 22, 2020

Axillary lymph node (LN) metastasis is the most important predictor of overall recurrence and survival in patients with breast cancer, and accurate assessment of axillary LN involvement is an essentia...

Concordance of real-world versus conventional progression-free survival from a phase 3 trial of endocrine therapy as first-line treatment for metastatic breast cancer.

Apr 22, 2020

There is growing interest in leveraging real-world data to complement knowledge gained from randomized clinical trials and inform the design of prospective randomized studies in oncology. The present ...

IR780 loaded sulfobetaine methacrylate-functionalized albumin nanoparticles aimed for enhanced breast cancer phototherapy.

Apr 22, 2020

New insights about nanomaterials' biodistribution revealed their ability to achieve tumor accumulation by taking advantage from the dynamic vents occurring in tumor's vasculature. This paradigm-shift ...

Advanced oxidation protein products upregulate efflux transporter expression and activity through activation of the Nrf-2-mediated signaling pathway in vitro and in vivo.

Apr 22, 2020

Clinical and benchtop studies suggest that chronic kidney disease (CKD) alters both renal and nonrenal clearance of drugs. Although studies have documented that the accumulating uremic toxins in the b...

Targeting self-assembly peptide for inhibiting breast tumor progression and metastasis.

Apr 22, 2020

The ubiquitous interactions between tumor cells and the surrounding microenvironment contribute to tumor metastasis, interrupting these communications has, therefore, a great potential for antimetasta...

Measures of Patient Dissatisfaction With Health Care in Polycystic Ovary Syndrome: Retrospective Analysis.

Apr 22, 2020

Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder in women; however, many clinicians may not be well versed in scientific advances that aid understanding of the associat...

Temporal Trends of Urogynecologic Mesh Reports to the U.S. Food and Drug Administration.

Apr 14, 2020

To compare temporal trends of urogynecologic mesh medical device reports with sentinel U.S. Food and Drug Administration (FDA) notices and to examine all linked reports of patient death.The Reed Tech ...

Delayed Treatment with Low-Intensity Extracorporeal Shock Wave Therapy in an Irreversible Rat Model of Stress Urinary Incontinence.

Apr 14, 2020

To determine the outcomes and mechanisms of delayed low-intensity extracorporeal shock wave therapy (Li-ESWT) in a rat model of irreversible SUI.Twenty-four female Sprague-Dawley rats were randomly as...

Cost Analysis of Vaginal Anti-Incontinence Procedures at a Tertiary Care Center.

Apr 14, 2020

To compare the cost of three vaginal procedures used in the surgical management of SUI at one tertiary institution.The costs of autologous fascial sling (AFS), synthetic mid-urethral sling (MUS), and ...

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