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OB/GYN General

Evaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: In vivo and in vitro, identification and mechanism.

Apr 14, 2020

Poria cocos Wolf (P. cocos), a well-known traditional East-Asian medicinal and edible fungus, is one of the most important components in Chinese medicine formulas like "Guizhi fuling wan" to treat hyp...

Design principles of drug combinations for chemotherapy.

Apr 14, 2020

Combination chemotherapy is the leading clinical option for cancer treatment. The current approach to designing drug combinations includes in vitro optimization to maximize drug cytotoxicity and/or sy...

Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer.

Apr 14, 2020

Breast cancer is a multi-factor disease, thus more and more drug combination therapies are applied in the treatment. However, there are undeniable disadvantages in drug combination therapy. Therefore,...

Artificial Intelligence: A New Paradigm in Obstetrics and Gynecology Research and Clinical Practice.

Apr 14, 2020

Artificial intelligence (AI) is growing exponentially in various fields, including medicine. This paper reviews the pertinent aspects of AI in obstetrics and gynecology (OB/GYN) and how these can be ...

OB/GYN perceptions of Prescription Drug Monitoring Programs as a primary prevention tool for neonatal abstinence syndrome.

Apr 14, 2020

The U.S. Centers for Disease Control and Prevention recommend clinicians use Prescription Drug Monitoring Program (PDMPs) as a risk assessment tool for opioid-related harms. This survey assessed perce...

Factors Associated With Response to Anorectal Biofeedback Therapy in Patients With Fecal Incontinence.

Apr 07, 2020

Anorectal biofeedback (BF) is commonly used to treat patients with fecal incontinence (FI), but demand usually exceeds availability. It is therefore important to identify patients most likely to respo...

Effect of the Sodium-Glucose Cotransporter 2 Inhibitor, Dapagliflozin, on Genitourinary Infection in an Animal Model of Type 2 Diabetes.

Apr 07, 2020

To investigate the effect of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, on inflammatory cytokines of urogenital tissue in a rat model of type 2 diabetes (T2DM) to infer pharmaceutical ...

Clinical and Urodynamic Predictors of the Q-Tip Test in Women With Lower Urinary Tract Symptoms.

Apr 07, 2020

The Q-tip test is used to measure urethral hypermobility and can predict surgical outcomes. However, certain factors may affect the reliability of this test. Our aim was to identify independent clinic...

Korean Translation and Linguistic Validation of Urgency and Overactive Bladder Questionnaires.

Apr 07, 2020

Given the importance of evaluating the severity of overactive bladder (OAB) symptoms and outcomes after treatment, several questionnaires have been developed to evaluate OAB patients. However, only li...

Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials.

Apr 07, 2020

Transcutaneous electrical neural stimulation (TENS), as a non-invasive modality, has been clinically used as an alternative treatment for children with overactive bladder (OAB). We conducted a pooled ...

HPV may not play a role in all lacrimal transitional cell papilloma.

Apr 07, 2020

Tumours of the lacrimal duct apparatus (LDA) are rare and heterogenous but knowledge of their aetiology is important for the rhinologist. A link between transitional cell papilloma/carcinoma (TCP/TCC)...

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.

Apr 07, 2020

In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual s...

Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-B pathway.

Apr 07, 2020

Loratadine is an antihistamine drug that shows promise as an anti-inflammatory drug, but supportive studies are lacking. We elucidated the effects and mechanisms by which loratadine inhibits inflammat...

Hepatitis E: an expanding epidemic with a range of complications.

Apr 07, 2020

Hepatitis E virus (HEV) is a common cause of viral hepatitis worldwide. Previously considered a disease of the developing world, it is increasingly recognised that locally acquired HEV infection is co...

The farnesyltransferase inhibitor tipifarnib protects against autoimmune hepatitis induced by Concanavalin A.

Apr 07, 2020

No effective treatment has been established for autoimmune hepatitis (AIH), except for liver transplantation in the fatal stage. Little is known about the roles and mechanisms of farnesyltransferase i...

Combination of Conservative Treatment and Temporary Bilateral Laparoscopic Uterine Artery Clipping with Hysteroscopic Transcervical Resection for Cervical Pregnancy: A Retrospective Study.

Apr 07, 2020

We investigated whether temporary bilateral laparoscopic uterine artery clipping with hysteroscopic transcervical resection (LUA clipping-TCR) is an effective minimally invasive treatment for the mana...

Postpartum Contraceptive Use Among Denver-Based Adolescents and Young Adults: Association with Subsequent Repeat Delivery.

Apr 07, 2020

To determine the association of postpartum contraceptive use with repeat deliveries among adolescents and youth.Retrospective, observational analysis of electronic health record data.Single, urban fac...

Harem stallion changes are not associated with diminished reproductive performance of females in semi-feral Konik polski horses (Equus caballus).

Apr 07, 2020

Infanticide, related to a stallion's aggression toward a foal sired by another stallion, and feticide related to a new stallion's aggression and/or pheromonal influence (the Bruce effect) inducing los...

Effect of equine chorionic gonadotropin (eCG) administration and proestrus length on ovarian response, uterine functionality and pregnancy rate in beef heifers inseminated at a fixed-time.

Apr 07, 2020

The objective of the present study was to evaluate the effect of equine chorionic gonadotropin (eCG) administration associated to different proestrus lengths for Fixed-time AI (FTAI) in beef heifers. ...

Establishing a high microbial load maternal-offspring asthma model in adult mice.

Apr 07, 2020

Although it is widely accepted that the "hygiene hypothesis" explains the increased incidence of asthma, the lack of suitable animal models hinders further in-depth studies of the underlying molecular...

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