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OB/GYN General

A phase 2b, randomized, placebo-controlled, double-blind, dose-ranging study of the neurokinin 3 receptor antagonist fezolinetant for vasomotor symptoms associated with menopause.

Feb 28, 2020

Menopausal vasomotor symptoms (VMS) may result from altered thermoregulatory control in brain regions innervated by neurokinin 3 receptor-expressing neurons. This phase 2b study evaluated seven dosing...

State of the Art in Fertility Preservation for Female Patients Prior to Oncologic Therapies.

Feb 28, 2020

Quality of life improvement stands as one of the main goals of the medical sciences. Increasing cancer survival rates associated with better early detection and extended therapeutic options led to the...

Pelvic floor muscle training: mechanisms of action for the improvement of genitourinary syndrome of menopause.

Feb 28, 2020

This study aims to investigate the mechanism of action of pelvic floor muscle training (PFMT) for the improvement of the signs and symptoms of genitourinary syndrome of menopause (GSM) in postmenopau...

Some of the Factors Involved in Male Infertility: A Prospective Review.

Feb 28, 2020

Infertility is defined as the inability of couples to have a baby after one year of regular unprotected intercourse, affecting 10 to 15% of couples. According to the latest WHO statistics, approximate...

Controversies Regarding Ovarian Suppression and Infertility in Early Stage Breast Cancer.

Feb 28, 2020

A common side effect of chemotherapy in breast cancer is early menopause in premenopausal patients, which is mainly a result of an indirect form of ovarian ablation, and is associated with substantial...

Rate of Significant Endometrial Pathology in Women at Low Risk for Endometrial Hyperplasia or Cancer Presenting with Abnormal Uterine Bleeding.

Feb 28, 2020

To determine the rate of significant endometrial abnormalities in premenopausal women at low risk for endometrial hyperplasia and cancer presenting with abnormal uterine bleeding (AUB).This descriptiv...

Endometriotic cell culture contamination and authenticity: a source of bias in in vitro research?

Feb 28, 2020

Are the primary cell cultures and cell lines used in endometriosis research of sufficient quality?Primary cells used in endometriosis research lack purity and phenotypic characterisation, and cell lin...

Patterns of antenatal corticosteroid administration in a cohort of women with diabetes in pregnancy.

Feb 28, 2020

Antenatal corticosteroids administered to the mother prior to birth decrease the risk of mortality and major morbidity in infants born at less than 35 weeks' gestation. However, the evidence relating ...

When a Stroke is not Just a Stroke: Meningitis with Ventriculitis and Vasculitis: A Case Report.

Feb 28, 2020

Community-acquired ventriculitis is considered a rare condition. Central nervous system (CNS) infection due to gram-negative bacilli is usually associated with previous neurosurgical interventions. T...

The oxidative fumarase FumC is a key contributor for E. coli fitness under iron-limitation and during UTI.

Feb 28, 2020

The energy required for a bacterium to grow and colonize the host is generated by metabolic and respiratory functions of the cell. Proton motive force, produced by these processes, drives cellular mec...

Case of catatonia misdiagnosed with coma.

Feb 25, 2020

Catatonia is a state of high-degree psychomotor inhibition in which patients often maintain a constant fixed posture, and generally have unconscious obstacles and various reflex preservation. Patients...

Evaluation of Renal Disease in Patients With Cirrhosis.

Feb 25, 2020

Renal dysfunction in cirrhosis is common and is associated with increased mortality. Identifying and treating reversible causes of renal disease can significantly improve outcomes. The etiology, appro...

Evaluation of durability of a single-dose of the bivalent HPV vaccine: the CVT Trial.

Feb 25, 2020

Investigate the durability of vaccine efficacy (VE) against HPV16/18 infections and antibody response among non-randomized women who received a single-dose of the bivalent HPV vaccine compared to wome...

Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: the CVT Trial.

Feb 25, 2020

The Costa Rica HPV Vaccine Trial (CVT) has documented cross-protection of the bivalent HPV vaccine against HPV31/33/45 up to seven years after vaccination, even with one dose of the vaccine. However, ...

Virus-associated anterior uveitis and secondary glaucoma: Diagnostics, clinical characteristics, and surgical options.

Feb 25, 2020

In this retrospective, single-center, observational study, we compared the clinical characteristics, analyzed the glaucoma development, and the glaucoma surgery requirement mediators in patients with ...

Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis.

Feb 25, 2020

We evaluated the efficacy and safety of upadacitinib, an oral selective inhibitor of Janus kinase 1, as induction therapy for ulcerative colitis (UC).We performed a multicenter, double-blind, phase 2b...

The Value of Parental Testing by Next-Generation Sequencing Includes the Detection of Germline Mosaicism.

Feb 25, 2020

When a potential disease-causing variant is detected in a proband, parental testing is used to determine the mode of inheritance. This study demonstrates that next-generation sequencing (NGS) is uniqu...

Application of a human mesoderm tissue elongation system in vitro derived from human induced pluripotent stem cells to risk assessment for teratogenic chemicals.

Feb 25, 2020

Toxic compounds from the mother's diet and medication in addition to genetic factors and infection during pregnancy remain risks for various congenital disorders and misbirth. To ensure the safety of ...

Epidemiology of pre-eclampsia in the Republic of Kazakhstan: Maternal and neonatal outcomes.

Feb 25, 2020

Pre-eclampsia (PE) still significantly contributes to maternal and neonatal morbidity and mortality. This study aimed at evaluation of the prevalence of PE among Kazakhstani women and on elucidation o...

Pregnancy in Advanced Kidney Disease: Clinical Practice Considerations on a Challenging Combination.

Feb 25, 2020

Thanks to the advances in care, pregnancy is now attainable for the majority of young female CKD patients, although it is still a high-risk endeavor. Clinical decision-making in these cases is impacte...

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