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OB/GYN General

TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer.

May 01, 2023

Ovarian cancer (OC) is known for exhibiting low response rates to immune checkpoint inhibitors that activate T cells. However, immunotherapies that activate B cells have not yet been extensively explo...

Actionable spontaneous antibody responses antagonize malignant progression in ovarian carcinoma.

May 01, 2023

To demonstrate that shared antibody responses in endometriosis and endometriosis-associated ovarian cancer spontaneously antagonize malignant progression and can be leveraged to develop future immunot...

Transcriptomic analysis reveals that the anti-PCOS effects of Zishen Qingre Lishi Huayu recipe may involve pathways and genes related to autophagy, steroidogenesis, oxidative stress, and inflammation in granulosa cells.

May 01, 2023

Zishen Qingre Lishi Huayu recipe (ZQLHR) is a Chinese medicine compound composed of nine herbs for the treatment of polycystic ovary syndrome (PCOS). It is used to nourish kidneys, clear heat, reduce ...

Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer.

May 01, 2023

Dysregulation of cellular metabolism is a hallmark of breast cancer progression and is associated with metastasis and therapeutic resistance. Here, we show that the breast tumor suppressor gene SIM2 p...

Sustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancer.

May 01, 2023

Triple-negative breast cancer (TBNC) is an aggressive breast cancer subtype with a poor prognosis. Shugoshin-1 (SGO1) protects chromatids from early separation. Previous studies from our group have de...

Evaluation of Online Distant Synchronous Interprofessional Simulations.

May 01, 2023

Formative interprofessional education is an accreditation standard for health professional student populations. This study examined the perception of midwifery students and obstetrics and gynecology (...

Bioactive lipid mediators in plasma are predictors of preeclampsia irrespective of aspirin therapy.

May 01, 2023

There are few early biomarkers to identify pregnancies at risk of preeclampsia (PE) and abnormal placental function. In this cross-sectional study, we utilized targeted ultra-performance liquid chroma...

Challenges in Referring Male Partners of Women Infected with Trichomonas Vaginalis

Apr 28, 2023

The following is a summary of "Challenges in male partner referral among trichomonas vaginalis-infected women," published in the FEBRUARY 2023 issue of Obstetrics and Gynecology by Muzny C, et al. ...

Analyzing Pregnant Women with HIV for APOs and Pro-inflammatory Fatty Acid Signatures

Apr 27, 2023

The following is a summary of "Association of pro-inflammatory fatty acid signatures with adverse pregnancy outcomes in pregnant persons living with human immunodeficiency virus," published in the FEB...

Severe COVID-19 in Pregnancy: Outcomes and Associations

Apr 26, 2023

The following is a summary of "Outcomes and associations of severe COVID-19 in pregnancy; results from the CANCOVID-preg population surveillance study," published in the FEBRUARY 2023 issue of Obstetr...

Association Between Infant Gut Microbiome and Maternal Vaginal Microbiome by Mode of Delivery

Apr 25, 2023

The following is a summary of "Relationship between the maternal vaginal microbiome and the infant gut microbiome by mode of delivery," published in the FEBRUARY 2023 issue of Obstetrics and Gynecolog...

De-labeling Penicillin Allergy in Pregnancy Leads to Safer Outcomes and Cost Savings

Apr 24, 2023

The following is a summary of "Safety and savings from penicillin allergy de-labeling in pregnancy: good stewardship, good cents," published in the FEBRUARY 2023 issue of Obstetrics and Gynecology by ...

Relationship between lower urinary tract symptoms and frailty.

Apr 24, 2023

To elucidate the relationship between frailty and lower urinary tract symptoms (LUTS).We longitudinally evaluated the temporal changes and the relationships between frailty and LUTS in 247 community-d...

Prenatal diagnosis with chromosome microarray analysis and pregnancy outcomes of fetuses with umbilical cord cysts.

Apr 24, 2023

To investigate the prenatal diagnostic value of chromosome microarray analysis (CMA) in fetuses with isolated or non-isolated umbilical cord cysts (UCCs) of various locations and numbers.Between Novem...

Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM).

Apr 24, 2023

Heat shock protein 60 (HSP60) is essential for the folding and assembly of newly imported proteins to the mitochondria. HSP60 is overexpressed in most types of cancer, but its association with ovarian...

Clinical risk management of breast, ovarian, pancreatic, and prostatic cancers for BRCA1/2 variant carriers in Japan.

Apr 24, 2023

Opportunities for genetic counseling and germline BRCA1/2 (BRCA) testing are increasing in Japan owing to cancer genomic profiling testing and companion diagnostics being covered by national health in...

The association between uterine adenomyosis and adverse obstetric outcomes: A propensity score-matched analysis.

Apr 24, 2023

This study examined obstetric outcomes in patients diagnosed with uterine adenomyosis.This historical cohort study queried the Healthcare Cost and Utilization Project's National Inpatient Sample. The ...

Near-Infrared Persistent Luminescence Nanoprobe for Ultrasensitive Image-Guided Tumor Resection.

Apr 24, 2023

Near-infrared (NIR) fluorescence imaging poses significant superiority over traditional medical imaging for tumor resection, thus having attracted widely attention. However, for tiny tumor residues, i...

Saikosaponin A alleviates glycolysis of breast cancer cells through repression of Akt/STAT3 pathway.

Apr 24, 2023

Saikosaponin A (SSA) has been revealed to have anti-breast cancer (BC) effect. However, the association between SSA and BC glycolysis is obscure. We want to probe the function and mechanism of SSA on ...

Effect of Brief Interpersonal Therapy on Depression During Pregnancy: A Randomized Clinical Trial.

Apr 24, 2023

Prenatal depression is prevalent with negative consequences for both the mother and developing fetus. Brief, effective, and safe interventions to reduce depression during pregnancy are needed.To evalu...

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