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OB/GYN General

Identification of Ovarian Cancer Therapeutic and Diagnostic Indicators Through Genomic Profiling

Nov 29, 2022

When compared to high grade serous ovarian cancer (HGSOC), low grade serous ovarian cancer (LGSOC) has distinct etiology, molecular, genetic, and clinical features. Limited testing, inconsistent histo...

DNA Methylation Profiling in the Blood for Ovarian Cancer Screening

Nov 29, 2022

Due to insufficient early detection methods, ovarian cancer remains a leading cause of death among gynecological malignancies. Therefore, DNA methylation profiling in blood samples was investigated fo...

HER2 Testing Platforms and Targeted Therapy Implications in Uterine Serous Carcinoma

Nov 28, 2022

Uterine serous carcinoma (USC) has HER2 as a major therapeutic and prognostic target. However, there is a lack of consensus on the best HER2 testing infrastructure, and testing recommendations have ev...

Splenectomy Outcomes During Cytoreductive Surgery for Epithelial Ovarian Cancer

Nov 28, 2022

Complications following cytoreductive surgery for Stage III or IV epithelial ovarian cancer with or without splenectomy are described, and opportunities for better post-splenectomy treatment are highl...

Pelvic Exenteration Outcomes: An Experience with the Brunschwig Procedure in the Current Era

Nov 28, 2022

For a study, it is essential to analyze the postoperative and oncologic results of pelvic exenteration for non-ovarian gynecologic cancers. From January 1, 2010, through December 31, 2019, researchers...

Advanced Ovarian Cancer Peritoneal Metastases Affect Surgery and Survival in Patients

Nov 25, 2022

Cytoreductive surgery (CRS) feasibility and the need for extensive surgery in patients with advanced ovarian cancer are difficult to assess. Therefore, it will be helpful to identify patients for CRS ...

How does PCC Improve the Wellbeing of Patients Receiving Treatment for Ovarian Cancer?

Nov 25, 2022

Ovarian cancer patients who report a higher level of patient-centered communication (PCC) have a higher health-related quality of life (HRQoL). TThe quantitative metrics of PCC and HRQoL does not well...

Mixed-methods Study on eSAC Use and Acceptability in Stage IV Ovarian Cancer

Nov 25, 2022

This study aimed to evaluate the feasibility and acceptability of a web-based patient reported outcome (PRO) program for persons with advanced ovarian cancer using electronic self-assessment and care ...

HIPEC after Neoadjuvant Chemotherapy Exhibited Tolerable Toxicity and QOL

Nov 24, 2022

Goal: to assess toxicity, quality of life, and progression-free survival (PFS) in patients with advanced ovarian cancer who underwent neoadjuvant chemotherapy (NAC) followed by CRS and HIPEC with carb...

Gemcitabine Plus Adavosertib or Placebo for Platinum-resistant Ovarian Cancer

Nov 24, 2022

A double-blind, randomized, placebo-controlled, phase 2 trial compared gemcitabine in combination with the WEE1 inhibitor adavosertib or placebo in patients with platinum-resistant or refractory high-...

Prexasertib (LY2606368) Phase 2 Trial for Platinum-resistant Ovarian Cancer

Nov 24, 2022

The most common type of ovarian cancer, high-grade serous ovarian cancer, has a dismal prognosis, and new treatments are desperately needed for individuals with platinum-resistant or -refractory disea...

Clinical Calculator Redefining the Prognosis for High-risk Early-Stage Ovarian Cancers

Nov 23, 2022

Among patients with early-stage high-risk epithelial ovarian cancer, researchers sought to evaluate the use of a clinical calculator in redefining prognosis and the need for treatment. Information on ...

Adjuvant Radiation Therapy Function in Older Patients with Node-positive Vulvar Cancer

Nov 23, 2022

This study's primary objective was to determine whether the survival benefit of adjuvant radiation for individuals with node-positive vulvar cancer is sustained in older patients. Patients aged 65 yea...

Screening for Cervical Cancer in a National Cohort: Under & Over-screening

Nov 23, 2022

The aim of this research was to examine the national cohort for under and over-screening for cervical cancer. Elements pertinent to cervical cancer screening among women aged 21–65 with 6 years of c...

Modern Endometrial Cancer Recurrence: When, Where, and How?

Nov 23, 2022

The purpose of this study is to investigate women who have had a second diagnosis of endometrial cancer and assess any trends in the disease's presentation or diagnosis. A look back at women who were ...

Radiation Treatment Duration and Survival in Advanced Vulvar Squamous Cell Carcinoma

Nov 22, 2022

In locally advanced squamous cell vulvar carcinoma, researchers aimed to determine whether or not timely completion of radiation therapy affected overall survival (OS). Women more than or equal to 18 ...

Clinical Outcomes in COVID-19 and Gynecologic Cancer Patients

Nov 22, 2022

It is unknown how COVID-19 infection would affect patients with gynecologic cancers. Researchers set out to document the clinical pathways, treatment modifications, and short-term clinical outcomes of...

Primary Treatment for Stages II–IV LGSOC Women: Relapse and Survival Factors

Nov 22, 2022

The goal of this research was to characterize a population of patients who were treated with low-grade serous ovarian/peritoneal carcinoma (LGSOC) at a modern primary care facility, with an emphasis o...

Support for Breastfeeding Via Text Messages Compared to Regular Care

Nov 18, 2022

For a study, researchers sought to determine whether a platform for postpartum SMS messaging increased breastfeeding rates. A control group that received weekly texts asking about baby feeding prac...

Deliveries Complicated by Cystic Fibrosis: Trends & Outcomes

Nov 17, 2022

For a study, researchers sought to describe the most recent patterns and outcomes in deliveries caused by cystic fibrosis (CF)-complicated pregnancies. In the repeated cross-sectional analysis, ind...

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