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OB/GYN General

Emulating a Target Trial to Compare the Efficacy of Clomiphene Citrate & Letrozole For Ovulation Induction

Apr 18, 2022

For a study, researchers sought to create a simulation of a hypothetical trial comparing the efficacy of letrozole against clomiphene citrate for ovulation induction in all women, then stratified by P...

Single-stage repair for female epispadias with urinary incontinence: A case report and literature review.

Apr 18, 2022

Epispadias is a rare condition. Epispadias in females is two times less common than in males. Female epispadias range from 1 in 160,000 to 480,000 live births. Epispadias can be diagnosed through care...

An effective AKT inhibitor-PARP inhibitor combination therapy for recurrent ovarian cancer.

Apr 18, 2022

Although the use of PARP inhibitor has received considerable amount of attention in ovarian cancer, PARP inhibitor resistance still emerges with disease progression. PI3K/AKT pathway inhibitors have b...

Accuracy of transvaginal ultrasound and magnetic resonance imaging for diagnosis of deep endometriosis in bladder and ureter: a meta-analysis.

Apr 18, 2022

This meta-analysis aimed to determine the accuracy of transvaginal ultrasound (TVS) and pelvic magnetic resonance imaging (MRI) in diagnosing urinary tract endometriosis (UTE). A comprehensive search ...

Facile fabrication of hypercrosslinked microporous polymer nanospheres for effective inhibition of triple negative breast cancer cells proliferation.

Apr 18, 2022

Treatment failure is one of the main lethal causes of human triple negative breast cancer (TNBC) patients due to inefficient drug administration. The present study demonstrated the development of func...

Smartly responsive DNA-miRNA hybrids packaged in exosomes for synergistic enhancement of cancer cell apoptosis.

Apr 18, 2022

Endogenous and exogenous tumor-related microRNAs (miRNAs) are considered promising tumor biomarkers and tumor therapeutic agents. In this work, we propose a miRNA self-responsive drug delivery system ...

Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia.

Apr 11, 2022

Vascular dementia is the second most prevalent form of dementia. Hypertension is the leading risk factor for endothelial dysfunction and the progression of dementia that is of vascular origin. This st...

Long-term outcomes of whole gland high-intensity focused ultrasound for localized prostate cancer.

Apr 11, 2022

To report the 10-year oncologic and functional outcomes of whole-gland HIFU as first-line treatment for localized prostate cancer (PCa).Patients were retrospectively included between January 2005 and ...

Basic and applied features in the cryopreservation progress of bovine embryos.

Apr 11, 2022

The expansion of the use of in vitro production techniques has revolutionized the bovine embryo market. In the last decade, we have seen the number of in vitro produced (IVP) embryos surpass the numbe...

Ovarian Cancer Ascites Inhibits Transcriptional Activation of NK Cells Partly through CA125.

Apr 11, 2022

Malignant ascites is a common clinical problem in ovarian cancer. NK cells are present in the ascites, but their antitumor activity is inhibited. The underlying mechanisms of the inhibition have yet t...

Updated meta-analysis on the diagnostic accuracy of serum anti-Mullerian hormone in poly cystic ovary syndrome involving 13 509 subjects.

Apr 11, 2022

To determine the diagnostic accuracy of anti-Mullerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS).Two independent reviewers searched the electronic databases and search engines...

Negative associations of ideal family size achievement with hypertension, obesity and maternal age in women with and without polycystic ovary syndrome.

Apr 11, 2022

To investigate lifetime reproductive outcomes and the relationship of ideal family size (IFS) achievement with metabolic, psychiatric and reproductive history in women with and without polycystic ovar...

The role of percutaneous vertebral augmentation in patients with metastatic breast cancer: Literature review including report of two cases.

Apr 11, 2022

Patients with metastatic breast cancer are at high risk for developing vertebral compression fractures due to underlying bone metastases and bone density loss. Vertebral augmentation techniques includ...

Understanding the limits of parametrial resection in radical hysterectomy: a randomized controlled trial.

Apr 11, 2022

The aim was to evaluate whether adding specific educational medical illustrations may help gynecologists to better understand the limits of parametrial resection in radical hysterectomy from type A to...

Challenges facing workstyle reform for Japanese obstetricians and gynecologists revealed from time studies.

Apr 11, 2022

We aimed to grasp the actual working hours of Japanese obstetricians and gynecologists (OB/GYN doctors) as accurately as possible, using the same method of the Ministry of Health, Labour, and Welfare ...

Duration of Postpartum Magnesium Sulphate for the Prevention of Eclampsia

Apr 07, 2022

For a study, researchers sought to determine the best time to use postpartum magnesium sulfate to avoid eclampsia. From their establishment until January 2020, the databases MEDLINE, EMBASE, CINAHL, t...

Digital Therapeutic Device for Urinary Incontinence

Apr 07, 2022

For a study, researchers sought to see if pelvic floor muscle training using a motion-based digital intravaginal device was more helpful than home pelvic floor muscle training for stress or stress-pre...

Geographic Variation in Apical Support Procedures for Pelvic Organ Prolapse

Apr 07, 2022

For a study, researchers sought to determine the regional variance in rates of apical support surgeries for the treatment of pelvic organ prolapse (POP) among female Medicare enrollees. They analyzed ...

Surgical Morbidity After Hysterectomy During an Obesity Epidemic

Apr 07, 2022

For a study, researchers sought to evaluate 30-day hysterectomy results by body mass index (BMI) categorization and to estimate changes in 30-day outcomes by BMI over time. It was a retrospective coho...

Effect of Topiramate on Serum Etonogestrel Concentrations

Apr 07, 2022

For a study, researchers sought to investigate the pharmacokinetic interactions of topiramate and etonogestrel in women who utilize contraceptive implants. They conducted a 12- to 36-month prospective...

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