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OB/GYN General

The environmental risk factors prior to conception associated with placental abruption: an umbrella review.

Apr 04, 2022

The present umbrella review evaluated risk factors prior to conception associated with placental abruption based on meta-analyses and systematic reviews.We searched PubMed, Scopus, and Web of Science ...

Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy.

Apr 04, 2022

Demand for nipple- and skin- sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications for post-mastectomy radiation therapy (PMRT) have broa...

Validity and utility of HER2/ERBB2 copy number variation assessed in liquid biopsies from breast cancer patients: A systematic review.

Apr 04, 2022

Addition of HER2-targeted treatment in breast cancer is mainly determined by the HER2-receptor status of primary breast cancer tissue, since longitudinal sampling is burdensome and often not feasible....

The urinary microbiome and biological therapeutics: Novel therapies for urinary tract infections.

Mar 28, 2022

The discovery of microbial communities in the urinary tract (the urobiome) has fundamentally altered the previous doctrine regarding urine sterility and associated urinary disorders. Recent advances i...

Follistatin dysregulation impaired trophoblast biological functions by GDF11-Smad2/3 axis in preeclampsia placentas.

Mar 28, 2022

Preeclampsia (PE) is one of the main causes of maternal, fetal, and neonatal mortality. So far, the underlying mechanism of this pregnancy-specific syndrome remains unelucidated. The expression of Fol...

Interaction between TMEFF1 and AHNAK proteins in ovarian cancer cells: Implications for clinical prognosis.

Mar 28, 2022

TMEFF1 is a newly discovered protein involved in the physiological functions of the central nervous system, embryonic development, and other biological processes. Our previous study revealed that TMEF...

Development of oxoisoaporphine derivatives with topoisomerase I inhibition and reversal of multidrug resistance in breast cancer MCF-7/ADR cells.

Mar 28, 2022

A series of oxoisoaporphine derivatives with topoisomerase I inhibition and cytotoxic activities. Among them, compound 14 showed the most potent cytotoxic activity against all cancer cell lines tested...

Synergistic effect of antimetabolic and chemotherapy drugs in triple-negative breast cancer.

Mar 28, 2022

The triple-negative breast cancer (TNBC) subtype comprises approximately 15% of all breast cancers and is associated with poor long-term outcomes. Classical chemotherapy remains the standard of treatm...

The virtual interview format for fellowship recruitment in obstetrics and gynecology: a nationwide survey of program directors.

Mar 28, 2022

Due to Covid-19, fellowship programs could not conduct in-person interviews during the 2020-2021 interview cycle and were forced to implement virtual interviews. We conducted two nationwide surveys of...

Breast Arterial Calcification Linked With CVD Postmenopause

Mar 23, 2022

“Calcium build-up within the middle layer of the breast’s arterial wall, known as breast arterial calcification (BAC), is commonly seen on mammograms,” explains Carlos Iribarren, MD, MPH, PhD. â...

Pelvic organ prolapse and anal incontinence in women: screening with a validated epidemiology survey.

Mar 21, 2022

The primary objective of this study was to determine the prevalence of pelvic organ prolapse (POP) and anal incontinence (AI) in a Minnesota population using the Epidemiology of Prolapse and Incontine...

Correlation between urinary symptoms and urodynamic findings: Is the bladder an unreliable witness?

Mar 21, 2022

The role of urodynamics as the gold standard to investigate bladder function has recently been questioned. We aimed to evaluate the agreement of lower urinary tract symptoms and urodynamic diagnosis a...

Physiological asymmetry in uterine artery blood flow during the first trimester of pregnancy: New insights from a quantitative assessment using Pulsed-wave color Doppler and M-mode color power angio imaging.

Mar 21, 2022

This study aimed to quantify uterine artery (UtA) blood flow and its hemodynamic components throughout the first trimester of pregnancy using Doppler ultrasound.Cross-sectional cohort study involving ...

Maternal, placental, and fetal distribution of titanium after repeated titanium dioxide nanoparticle inhalation through pregnancy.

Mar 21, 2022

Epidemiological studies have associated ambient engineered nanomaterials or ultrafine particulate matter (PM), collectively referred to as nanoparticles (NPs), with adverse pregnancy outcomes includin...

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.

Mar 21, 2022

The tumor microenvironment hosts antibody-secreting cells (ASCs) associated with a favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic and therapeutic potential;...

Effects of capecitabine as part of neo-/adjuvant chemotherapy - A meta-analysis of individual breast cancer patient data from 13 randomised trials including 15,993 patients.

Mar 21, 2022

Despite the large number of patients with early breast cancer (EBC) who have been treated with capecitabine in randomised trials, no individual patient data meta-analysis has been conducted. The prima...

Gender bias in the medical education of obstetrician-gynaecologists in the United States: A systematic review.

Mar 21, 2022

The number of men entering obstetrics and gynaecology (Ob/Gyn) residencies and general Ob/Gyn practice is decreasing. Gender biases against their participation may affect career decisions.This systema...

Contributions of artificial intelligence reported in Obstetrics and Gynecology journals: a systematic review.

Mar 21, 2022

Background. The applications of artificial intelligence (AI) processes have grown significantly in all medical disciplines during the last decades. Two main types of AI have been applied in Medicine: ...

Medical Cannabis for Gynecologic Pain Conditions

Mar 17, 2022

The endocannabinoid system is implicated in pain perception and inflammation. Cannabinoids that bind to endocannabinoid system receptors in cannabis include delta-9-tetrahydrocannabinol (THC) and cann...

Surgical Removal of Midurethral Sling in Women

Mar 17, 2022

When removing a midurethral sling for problems, determine if some or all of the mesh had to be removed. A systematic review and meta-analysis were carried out. From January 1, 1996, to May 1, 2021, th...

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