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OB/GYN General

Serotyping of the Herpes Simplex Virus in Pregnant Women With a History of Genital Herpes and an Outbreak in the Third Trimester

Feb 14, 2022

Researchers sought to determine if serotyping pregnant women with a history of genital herpes simplex virus (HSV) and an outbreak during the third trimester of pregnancy is more cost-effective than no...

Under-classified obstetric anal sphincter injuries.

Feb 14, 2022

Obstetric anal sphincter injuries (OASIs) that are missed at delivery can have long-term consequences. OASIs that are under-classified at delivery are likely to be inadequately repaired, resulting in ...

Phase I trial of ATM inhibitor M3541 in combination with palliative radiotherapy in patients with solid tumors.

Feb 14, 2022

Ataxia telangiectasia mutated (ATM) kinase orchestrates DNA double strand break (DSB) repair; ATM inhibitors may therefore enhance the therapeutic effect of DSB-inducing treatments such as radiotherap...

Effects of estradiol cypionate dose as an ovulatory stimulus on reproductive performance of lactating dairy cows during the summer season.

Feb 14, 2022

This experiment was designed to evaluate the effects of increasing doses of estradiol cypionate (ECP) on reproductive function of lactating dairy cows during the summer. In Exp. 1, 643 lactating Holst...

BRCA1/2 variants of unknown significance in hereditary breast and ovarian cancer (HBOC) syndrome: looking for the hidden meaning.

Feb 14, 2022

Hereditary breast and ovarian cancer syndrome is caused by germline mutations in BRCA1/2 genes. These genes are very large and their mutations are heterogeneous and scattered throughout the coding seq...

Validity and Reliability of the Turkish Version of Screening Tool on Distress in Fertility Treatment (SCREENIVF).

Feb 14, 2022

Women diagnosed with infertility and receiving infertility treatment reported high levels of depressive symptoms, anxiety and distress. Infertile women should first be screened for psychosocial risks....

The effect of pharmacological cessation and restoration of menstrual cycle on bone metabolism in premenopausal women with endometriosis.

Feb 14, 2022

GnRH-analogs induce bone loss. We aimed to investigate the effects of goserelin-induced menstrual cessation (MC) and subsequent menstrual restoration (MR) on bone metabolism (BM).In this prospective c...

Optimal localization strategies for non-palpable breast cancers -A network meta-analysis of randomized controlled trials.

Feb 14, 2022

Mammographic screening programmes have increased detection rates of non-palpable breast cancers. In these cases, wire-guided localization (WGL) is the most common approach used to guide breast conserv...

Treatment-driven tumour heterogeneity and drug resistance: Lessons from solid tumours.

Feb 14, 2022

Molecular heterogeneity characterizes tumours' evolution and adaptation and, because of its dynamics and continuous changes under external pressure, it is one of the major causes of drug resistance, c...

Understanding Patient Evaluation of Abnormal Uterine Bleeding (AUB): A Standardized Patient Case on AUB for OB/GYN Clerkship Students.

Feb 14, 2022

The differential diagnosis for abnormal uterine bleeding (AUB) among reproductive-age women is broad and includes common and life-threatening conditions. Recognition and accurate diagnosis of AUB are ...

Effect of Age on Complications Rate and Surgical Outcomes in Women Undergoing Laparoscopic Sacrohysteropexy and Sacrocolpopexy.

Feb 07, 2022

To compare perioperative and long-term outcomes of laparoscopic sacrohysteropexy/sacrocolpopexy in different groups of age.This was a retrospective cohort study. Patients were evaluated preoperatively...

Impact of urinary incontinence on anxiety status during pregnancy: A prospective case-control study.

Feb 07, 2022

To evaluate the impact of the presence and severity of urinary incontinence (UI) on pregnancy-related anxiety.This prospective case-control study included 160 pregnant women. Pregnant women with UI (n...

Effectiveness of cognitive behavioral therapy for perinatal maternal depression, anxiety and stress: A systematic review and meta-analysis of randomized controlled trials.

Feb 07, 2022

Cognitive behavioral therapy (CBT) has been widely studied in prenatal or postnatal depression, with much less research on anxiety and stress. This meta-analysis aims to comprehensively evaluate CBT e...

A functionalized graphene oxide with improved cytocompatibility for stimuli-responsive co-delivery of curcumin and doxorubicin in cancer treatment.

Feb 07, 2022

Nowadays, the usage of nanoparticles in various fields such as drug delivery, attracts the attention of many researchers in the treatment of cancers. Graphene oxide (GO) is one of the novel drug deliv...

Maintenance Therapy for Preventing Endometrioma Recurrence after Endometriosis Resection Surgery-A Systematic Review and Network Meta-analysis.

Feb 07, 2022

To evaluate the efficacy of different hormone therapies in preventing postoperative endometrioma recurrence.The MEDLINE, COCHRANE and Embase electronic databases were searched from inception to 30 Apr...

Nomogram for predicting the long-term outcomes of uterine artery embolization for adenomyosis.

Feb 07, 2022

The present study aimed to develop a nomogram to predict long-term outcomes of uterine artery embolisation (UAE) for treating adenomyosis.We reviewed data of 221 patients with adenomyosis who underwen...

Increase in ADAR1p110 activates the canonical Wnt signaling pathway associated with aggressive phenotype in triple negative breast cancer cells.

Feb 07, 2022

Triple-negative breast cancer (TNBC) represents a challenge in the search for new therapeutic targets. TNBCs are aggressive and generate resistance to chemotherapy. Tumors of TNBC patients with poor p...

Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships.

Feb 07, 2022

A new series of fifty-four 2-phenol-4-aryl-6-hydroxyphenylpyridines containing fluorophenyl, trifluoromethylphenyl, and trifluoromethoxy phenyl groups were synthesized and tested for topoisomerase IIÎ...

Medium term anatomical and functional outcomes following modified laparoscopic sacrocolpopexy.

Jan 31, 2022

We evaluated the anatomical and functional outcomes following modified laparoscopic sacrocolpopexy (LSC) utilizing deep dissection of the vaginal walls and distal mesh fixation at the anterior and pos...

The Development of F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1.

Jan 31, 2022

Fluorine 18 (F) fluorthanatrace (F-FTT) is a PET radiotracer for imaging poly (adenosine diphosphate-ribose) polymerase-1 (PARP-1), an important target for a class of drugs known as PARP inhibitors, o...

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