Dec 15, 2021

The use of multigene sequencing as a therapeutic decision tool improved the outcomes for patients with metastatic breast cancer when the genomic alterations identified were ranked in the I/II tiers of...

Dec 15, 2021

The pathways leading to CDK4/6 inhibitor resistance are not yet clear. Using a technique called ‘accelerated mutagenesis’, researchers unraveled the role of ASXL1 loss. Initial findings in ER-posi...

Dec 15, 2021

Development of breast cancer-related lymphedema is not equally distributed between races. Black women experienced higher rates of breast cancer-related lymphedema than White women, results of a prospe...

Dec 15, 2021

Efficacy of second-line treatment option for patients with ER-positive/HER2-negative metastatic breast cancer who progress on an aromatase inhibitor plus CDK4/6 inhibitor is poor. In a first-in-human ...

Dec 15, 2021

The phase 3 BioItaLEE trial demonstrates that pre-treatment circulating tumor DNA (ctDNA) and early dynamics of ctDNA represent promising prognostic and predictive biomarkers in patients with HR-posit...

Dec 15, 2021

Adjuvant treatment with the PARP inhibitor olaparib showed beneficial effects for patients with BRCA1/2 mutations and high-risk, HER2-negative, early-stage, primary breast cancer. In addition, patient...

Dec 15, 2021

Both patients with heavily pre-treated HR-positive/HER2-negative, HER2-mutated, metastatic breast cancer and patients with heavily pre-treated HER2-mutated metastatic triple-negative breast cancer (TN...

Dec 15, 2021

Long-term use of tamoxifen is associated with an increased risk for the development of uterine cancer. New research shows that tamoxifen directly activates a signaling pathway (PIK3) that is a well-kn...

Dec 15, 2021

In pre-menopausal women with early-stage, ER-positive breast cancer, adjuvant ovarian suppression can be combined with tamoxifen or an aromatase inhibitor. A meta-analysis of 4 randomized controlled t...

Dec 15, 2021

Taxane with or without anthracycline reduces the recurrence rate of early-stage breast cancer. A meta-analysis based on data of 18,203 participants now demonstrates anthracycline/taxane to reduce the ...

Dec 15, 2021

For a study, the researchers wanted to describe the rationale for and complication rates of retained cervix excision following supracervical hysterectomy. In the 2010–2014 National Inpatient Samp...

Dec 15, 2021

For a study, researchers wanted to determine the relationship between habitus measurements, pelvic floor support, and symptoms in primiparous women 1 year following term vaginal birth.  The study ...

Dec 15, 2021

For a study, researchers wanted to see if adding triamcinolone acetonide to a regular bladder installation solution may help in the treatment of interstitial cystitis–bladder pain syndrome. This was...

Dec 15, 2021

To evaluate the effectiveness of mifepristone pretreatment with misoprostol alone for termination of pregnancy following the fetal demise in the second trimester was the study’s aim.  This prosp...

Dec 14, 2021

Both adjuvant therapy with trastuzumab deruxtecan (T-DXd) and trastuzumab emtansine (T-DM1) have shown to improve progression-free survival in patients with HER2-positive, metastatic breast cancer. In...

Dec 14, 2021

The phase 3 RxPONDER trial evaluated the benefit of adjuvant chemotherapy followed by endocrine therapy in women with HR-positive, HER2-negative, early-stage breast cancer and 1–3 positive nodes. Up...

Dec 14, 2021

The purpose of this study was to see if a superior hypogastric plexus block done during a laparoscopic hysterectomy lowers postoperative discomfort. A multicenter, randomized, single-blind, control...

Dec 13, 2021

The research was conducted to compare the length of the second stage of labor in twin and singleton gestations and evaluate the length of the second stage of labor in twin births. The retrospective...

Dec 13, 2021

To compare non-Hispanic White women with racial-ethnic minority women in the equal-access Military Health System in terms of receipt of the National Comprehensive Cancer Network Guideline–adherent t...

Dec 13, 2021

The objective of this study was to assess the efficacy and acceptability of mifepristone abortion medicine provided by pharmacists. From July 2018 to March 2020, researchers performed a prospective...