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OB/GYN General

Design, synthesis and biological activity evaluation of novel scopoletin-NO donor derivatives against MCF-7 human breast cancer in vitro and in vivo.

Jul 29, 2021

In this study, eleven new 3- and 7-positions modified scopoletin derivatives (18a-k) were designed, synthesized, and biologically evaluated against human breast cancer cell lines. Most compounds showe...

Synthesis, characterization of ruthenium(II), nickel(II), palladium(II), and platinum(II) triphenylphosphine-based complexes bearing an ONS-donor chelating agent: Interaction with biomolecules, antioxidant, in vitro cytotoxic, apoptotic activity and cell cycle analysis.

Jul 29, 2021

Four new transition metal complexes, [M(PPh)(L)]CHOH (M = Ni(II) (1), Pd(II) (2)) [Pt (PPh)(HL)]Cl (3) and [Ru(CO)(PPh)(L)] (4) (HL = 2,4-dihydroxybenzaldehyde-S-methyldithiocarbazate, PPh = tri...

Professional Address during Obstetrics and Gynecology Grand Rounds Introductions: Setting the Stage, Setting the Standard.

Jul 29, 2021

This study aimed to assess gender dynamics during Obstetrics and Gynecology (Ob/Gyn) Grand Rounds.This was an observational cohort study of Ob/Gyn Grand Rounds introductions at a large academic center...

Training the Next Generation of Obstetrics and Gynecology Leaders, A Multi-Institutional Needs Assessment.

Jul 29, 2021

To assess resident and faculty interest in, as well as content and preferred format for, a leadership curriculum during obstetrics and gynecology residency DESIGN: From June to July 2019, a needs asse...

Evaluation of the InTray and Compact Dry culture systems for the diagnosis of urinary tract infections in patients presenting to primary health clinics in Harare, Zimbabwe.

Jul 26, 2021

Antimicrobial resistance surveillance data is lacking from many resource-limited settings mainly due to limited laboratory testing. Novel culture systems may address some of the limitations of convent...

Efficacy and safety of onabotulinumtoxinA in patients with overactive bladder: subgroup analyses by sex and by serum prostate-specific antigen levels in men from a randomized controlled trial.

Jul 26, 2021

We aimed to assess onabotulinumtoxinA treatment outcomes by sex in patients with overactive bladder (OAB) and then explore the impact of serum prostate-specific antigen (PSA) levels in men.Patients in...

Access to Postabortion Contraception: ACOG Committee Opinion Summary, Number 833.

Jul 26, 2021

All contraceptive methods are safe and effective when provided immediately after abortion procedures and when otherwise medically appropriate for a patient. Providing a contraceptive method immediatel...

Access to Postabortion Contraception: ACOG Committee Opinion, Number 833.

Jul 26, 2021

All contraceptive methods are safe and effective when provided immediately after abortion procedures and when otherwise medically appropriate for a patient. Providing a contraceptive method immediatel...

Drugs in Pregnancy and Lactation - Medications used in Swiss Obstetrics.

Jul 26, 2021

In order to improve the safety of drugs in pregnancy and lactation, it is imperative that data on clinical practice be collected and validated.Data on routinely used medications were requested from 9 ...

Hypermethylation of Genes in New Long Noncoding RNA in Ovarian Tumors and Metastases: A Dual Effect.

Jul 26, 2021

The role of methylation in the regulation of genes of long noncoding RNA (lncRNA) is still poorly understood. We revealed new hypermethylated lncRNA genes in ovarian tumors and their effect on metasta...

Prognostic nomogram for progression-free survival in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer on maintenance olaparib therapy following response to chemotherapy.

Jul 26, 2021

The impact of maintenance therapy with PARP inhibitors (PARPi) on progression-free survival (PFS) in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer (PSROC) varies widely....

Platinum complexes inhibit HER-2 enriched and triple-negative breast cancer cells metabolism to suppress growth, stemness and migration by targeting PKM/LDHA and CCND1/BCL2/ATG3 signaling pathways.

Jul 26, 2021

Triple-negative-breast cancer (TNBC) and HER-2 enriched positive aggressive types of breast cancer and are highly metastatic in nature. Anticancer agents those target TNBC and HER-2 enriched positive ...

Tumor Budding is a reliable predictor for death and metastasis in invasive ductal breast cancer and correlates with other prognostic clinicopathological parameters.

Jul 26, 2021

Breast cancers are the most common type of cancer and the most common cause of mortality in women worldwide. Different prognostic factors are the subject of research to differentiate the prognosis eve...

Comprehensive analysis of BTN3A1 in cancers: mining of omics data and validation in patient samples and cellular models.

Jul 26, 2021

Butyrophilin 3A1 (BTN3A1), a major histocompatibility complex (MHC)-associated gene that encodes a membrane protein with 2 extracellular immunoglobulin domains and an intracellular B30.2 domain, is cr...

Examining Chemotherapy–Radiation Sequencing for Uterine Cancer

Jul 24, 2021

“The optimal adjuvant therapy for women with advanced endometrial cancer remains controversial,” says Gretchen Glaser, MD. “It is unclear how to best sequence adjuvant chemotherapy and radiother...

Black Women Underrepresented in Immunotherapy Trials

Jul 23, 2021

“Racial inequity in healthcare delivery and outcomes in the United States is well-documented, and outcomes for breast and gynecologic cancers are no exception,” explains Katherine V. Grette, MD. �...

Comparative Study of ESBL Production Among Uropathogenic Escherichia coli Clinical Isolates from Pre- and Post-menopausal Women in Egypt.

Jul 22, 2021

Urinary tract infection (UTI) is regarded one of the most frequent bacterial infections in women. Accordingly, the aim of the current study was to determine the prevalence of extended-spectrum beta-la...

Short-term efficacy and mechanism of electrical pudendal nerve stimulation versus pelvic floor muscle training plus transanal electrical stimulation in treating post-radical prostatectomy urinary incontinence.

Jul 22, 2021

To assess the short-term efficacy of electrical pudendal nerve stimulation (EPNS) versus pelvic floor muscle training (PFMT) plus transanal electrical stimulation (TES) for the early treatment of post...

Assessment of sacral spinal excitability using stimulus-response curves of the bulbocavernosus reflex.

Jul 22, 2021

To analyze and quantify sacral spinal excitability through bulbocavernosus reflex (BCR) stimulus-response curves.Thirty subjects with upper motor neuron lesions (UMN) and nine controls were included i...

Are two children at once better than one? Risk analysis of twin pregnancies and births after assisted reproduction.

Jul 22, 2021

Pregnancies and births following assisted reproductive treatment (ART) are related to an increased risk for adverse perinatal outcomes. The aim of this retrospective cohort study at a University Hospi...

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