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OB/GYN General

Drugs in Pregnancy and Lactation - Medications used in Swiss Obstetrics.

Jul 26, 2021

In order to improve the safety of drugs in pregnancy and lactation, it is imperative that data on clinical practice be collected and validated.Data on routinely used medications were requested from 9 ...

Hypermethylation of Genes in New Long Noncoding RNA in Ovarian Tumors and Metastases: A Dual Effect.

Jul 26, 2021

The role of methylation in the regulation of genes of long noncoding RNA (lncRNA) is still poorly understood. We revealed new hypermethylated lncRNA genes in ovarian tumors and their effect on metasta...

Prognostic nomogram for progression-free survival in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer on maintenance olaparib therapy following response to chemotherapy.

Jul 26, 2021

The impact of maintenance therapy with PARP inhibitors (PARPi) on progression-free survival (PFS) in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer (PSROC) varies widely....

Platinum complexes inhibit HER-2 enriched and triple-negative breast cancer cells metabolism to suppress growth, stemness and migration by targeting PKM/LDHA and CCND1/BCL2/ATG3 signaling pathways.

Jul 26, 2021

Triple-negative-breast cancer (TNBC) and HER-2 enriched positive aggressive types of breast cancer and are highly metastatic in nature. Anticancer agents those target TNBC and HER-2 enriched positive ...

Tumor Budding is a reliable predictor for death and metastasis in invasive ductal breast cancer and correlates with other prognostic clinicopathological parameters.

Jul 26, 2021

Breast cancers are the most common type of cancer and the most common cause of mortality in women worldwide. Different prognostic factors are the subject of research to differentiate the prognosis eve...

Comprehensive analysis of BTN3A1 in cancers: mining of omics data and validation in patient samples and cellular models.

Jul 26, 2021

Butyrophilin 3A1 (BTN3A1), a major histocompatibility complex (MHC)-associated gene that encodes a membrane protein with 2 extracellular immunoglobulin domains and an intracellular B30.2 domain, is cr...

Examining Chemotherapy–Radiation Sequencing for Uterine Cancer

Jul 24, 2021

“The optimal adjuvant therapy for women with advanced endometrial cancer remains controversial,” says Gretchen Glaser, MD. “It is unclear how to best sequence adjuvant chemotherapy and radiother...

Black Women Underrepresented in Immunotherapy Trials

Jul 23, 2021

“Racial inequity in healthcare delivery and outcomes in the United States is well-documented, and outcomes for breast and gynecologic cancers are no exception,” explains Katherine V. Grette, MD. â...

Comparative Study of ESBL Production Among Uropathogenic Escherichia coli Clinical Isolates from Pre- and Post-menopausal Women in Egypt.

Jul 22, 2021

Urinary tract infection (UTI) is regarded one of the most frequent bacterial infections in women. Accordingly, the aim of the current study was to determine the prevalence of extended-spectrum beta-la...

Short-term efficacy and mechanism of electrical pudendal nerve stimulation versus pelvic floor muscle training plus transanal electrical stimulation in treating post-radical prostatectomy urinary incontinence.

Jul 22, 2021

To assess the short-term efficacy of electrical pudendal nerve stimulation (EPNS) versus pelvic floor muscle training (PFMT) plus transanal electrical stimulation (TES) for the early treatment of post...

Assessment of sacral spinal excitability using stimulus-response curves of the bulbocavernosus reflex.

Jul 22, 2021

To analyze and quantify sacral spinal excitability through bulbocavernosus reflex (BCR) stimulus-response curves.Thirty subjects with upper motor neuron lesions (UMN) and nine controls were included i...

Are two children at once better than one? Risk analysis of twin pregnancies and births after assisted reproduction.

Jul 22, 2021

Pregnancies and births following assisted reproductive treatment (ART) are related to an increased risk for adverse perinatal outcomes. The aim of this retrospective cohort study at a University Hospi...

3D stem cell-laden artificial endometrium: successful endometrial regeneration and pregnancy.

Jul 22, 2021

Serious injuries of the endometrium (the innermost lining layer of the uterus) or naturally thin endometrium can cause uterine dysfunction and subsequently predispose patients to infertility or miscar...

Levetiracetam exposure during prenatal and postnatal period induces cognitive decline in rat offsprings, not completely prevented by .

Jul 22, 2021

Levetiracetam (LEV) is an antiepileptic recommended during pregnancy. is a medicinal herb used in Ayurveda for improvement of cognition. Data on effects of LEV and Bacopa on cognition is inadequate. ...

Gadolinium-labeled affibody-XTEN recombinant vector for detection of HER2+ lesions of ovarian cancer lung metastasis using quantitative MRI.

Jul 22, 2021

Ovarian cancer has the highest mortality rate among all gynecologic malignancies. HER2 ovarian cancer is a subtype that is aggressive and associated with metastasis to distant sites such as the lungs....

Potential of thrombospondin-1 in treatment of polycystic ovary syndrome rat model: a preliminary study.

Jul 22, 2021

Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease in reproductive women, and the endocrine levels are also affected by diseases. The aim of this study was to determine the e...

CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Drug Response: A Secondary Analyses of the KARISMA Trial.

Jul 22, 2021

Guidelines are conflicting and have caused confusion regarding whether tamoxifen should be prescribed based on women's CYP2D6 genotypes. This study aims to investigate if CYP2D6 metabolizer status is ...

OncotypeDX© Recurrence Score in BRCA mutation carriers: a systematic review and meta-analysis.

Jul 22, 2021

There are limited data comparing the OncotypeDX© Recurrence Score (RS) among BRCA mutation carriers and patients with sporadic breast cancer.To compare RS results among BRCA mutation carriers and pat...

A radiation ulcer that required partial lung resection and recurred in a small residual area of ectopic calcification.

Jul 22, 2021

Surgery for chest radiation ulcers must involve appropriate wide margins, but it is not usually possible to remove all radiation-damaged tissue. Therefore, it is difficult to determine how extensive s...

Implementation and Assessment of a Novel Telehealth Education Curriculum for Undergraduate Medical Students.

Jul 22, 2021

Despite its healthcare advantages and expanded use during the COVID-19 pandemic, telehealth is not included in many medical school curricula.In this prospective mixed methods study (n=52), we created ...

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