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OB/GYN General

Assessment of the Benefits and Cost-Effectiveness of Population-Based Breast Cancer Screening in Urban China: A Model-Based Analysis.

Jul 19, 2021

To decrease the burden of breast cancer (BC), the Chinese government recently introduced biennial mammography screening for women aged 45-70 years. In this study, we assess the effectiveness and cost-...

Play and Learn for Surgeons: A Serious Game to Educate Medical Residents in Uterine Artery Ligation Surgery.

Jul 19, 2021

Postpartum hemorrhage (PPH) is a leading cause of maternal mortality. Surgical interventions, such as uterine artery ligation and utero-ovarian arteries ligation (UAL and UOAL), are considered as eff...

The Costs and Healthcare Resource Utilization Associated with Anticholinergic Burden in Long-Stay Nursing Home Residents with Overactive Bladder in the US.

Jul 15, 2021

Overactive bladder (OAB) is a prevalent condition commonly treated with anticholinergic medications. The extent to which anticholinergic burden is associated with costs and healthcare resource use (HC...

Using Search Trends to Analyze Web-Based Interest in Lower Urinary Tract Symptoms-Related Inquiries, Diagnoses, and Treatments in Mainland China: Infodemiology Study of Baidu Index Data.

Jul 15, 2021

Lower urinary tract symptoms (LUTS) are one of the most commonly described urination disorders worldwide. Previous investigations have focused predominantly on the prospective identification of cases ...

C-L Case Conference: A 73-Year-Old Man with "Altered Mental Status" and Agitation.

Jul 15, 2021

Delirium is one of the most common reasons for psychiatric consultation in the general hospital. Delayed recognition can lead to increased morbidity and mortality among other complications. Learning t...

Non-linear and non-additive associations between the pregnancy metabolome and birthweight.

Jul 15, 2021

Birthweight is an indicator of fetal growth and environmental-related alterations of birthweight have been linked with multiple disorders and conditions progressing into adulthood. Although a few stud...

Viral model of maternal immune activation alters placental AMPK and mTORC1 signaling in rats.

Jul 15, 2021

Maternal immune activation (MIA) is associated with neurodevelopmental disorders in offspring. We previously demonstrated that poly(I:C)-mediated MIA alters placental and fetal brain amino acid transp...

Sperm Selection Technology in ART.

Jul 15, 2021

Intracytoplasmic sperm injection (ICSI) is a commonly used in vitro fertilization technique. Selection of sperm for injection is currently done using subjective assessment of morphology, which may not...

Tumor-suppressing effect of bartogenic acid in ovarian (SKOV-3) xenograft mouse model.

Jul 15, 2021

Bartogenic acid (BA), a natural pentacyclic triterpenoid, proved to have chemomodulatory, anticancer, antidiabetic, anti-arthritic, and anti-inflammatory activity. Based on structure-activity relation...

A systematic review of the prevalence of germline pathogenic variants in patients with pancreatic cancer.

Jul 15, 2021

The genetics of pancreatic ductal adenocarcinoma (PDAC) is complex with patients reported to harbor germline pathogenic variants (PVs) in many different genes. PDAC patients with familial pancreatic c...

Hsa_circ_0006404 and hsa_circ_0000735 Regulated Ovarian Cancer Response to Docetaxel Treatment via Regulating p-GP Expression.

Jul 15, 2021

Several microRNAs (miRNAs) and circular RNAs (circRNAs) were reported to be involved in the Docetaxel (DTX) chemoresistance of cancer treatment, but the underlying mechanisms remain to be explored. In...

Impact of yoga intervention on menopausal symptoms-specific quality of life and changes in hormonal level among menopausal women.

Jul 15, 2021

The menopause transition is experienced by women often involves troublesome symptoms due to changes in the level of reproductive hormones. Non-hormonal therapies are more commonly accepted by women th...

Aging and changes in adiposity indices: the impact of menopause.

Jul 15, 2021

Aging is associated with significant changes in fat distribution and menopause may alter this process. This study aimed to investigate the longitudinal effect of menopause on changes in adiposity indi...

Safety of hormone replacement therapy in women with a history of cervical adenocarcinoma.

Jul 15, 2021

Studies investigating the safety of hormone replacement therapy in cervical cancer have predominantly included patients with squamous disease. Pathological studies have identified estrogen receptor po...

Comparison of the efficacy of letrozole stair-step protocol with clomiphene citrate stair-step protocol in the management of clomiphene citrate-resistant polycystic ovary syndrome patients.

Jul 15, 2021

We sought to compare the efficacy of the letrozole (LTZ) stair-step protocol with clomiphene citrate (CC) stair-step protocol in the management of 150 mg dose of CC-resistant polycystic ovary syndro...

Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse.

Jul 15, 2021

Spermatozoa are polarized cells with a head and a flagellum joined together by the connecting piece. Flagellum integrity is critical for normal sperm function, and flagellum defects consistently lead ...

Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women.

Jul 15, 2021

Approximately 40% of human pregnancies are unintended, indicating a need for more acceptable effective contraception methods. New antibody production systems make it possible to manufacture reagent-gr...

Cancer Mortality and Research Outcomes in a Rural State.

Jul 15, 2021

North Dakota is a rural state with high rates of cancer. Determining how various demographic, geographic, and funding factors contributed to cancer incidence on a state and county level helps improve ...

Building and Behavior of A pH-Stimuli Responsive Chitosan Nanoparticles Loaded with Folic Acid Conjugated Gemcitabine Silver Colloids In MDA-MB-453 Metastatic Breast Cancer Cell Line and Pharmacokinetics In Rats.

Jul 15, 2021

The pH-stimuli release behavior of nanoformulations may enhance the success rate of chemotherapeutic drugs in cancers by site-specific delivery of drugs to cancer tissues. The aim of the present study...

Risk and influencing factors for subsequent primary lung cancer after treatment of breast cancer: a systematic review and two meta-analyses based on four million cases.

Jul 15, 2021

To compare the risk of developing lung cancer between breast cancer patients and the general population and explore the risk factors for the development of primary lung cancer after treatment for brea...

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