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OB/GYN General

Mechanism and Priority of Botulinum Neurotoxin A versus Sacral Neuromodulation for Refractory Overactive Bladder: A Review.

Jun 17, 2021

The treatment of common overactive bladder (OAB) has reached a consensus, but there is not a clear answer to the treatment of refractory OAB (ROAB). ROAB is defined as nonresponsive to treatment with ...

Is Lupus Anticoagulant a Significant Feature of COVID-19? A Critical Appraisal of the Literature.

Jun 17, 2021

The term "lupus anticoagulant (LA)" identifies a form of antiphospholipid antibodies (aPLs) causing prolongation of clotting tests in a phospholipid concentration-dependent manner. LA is one of the la...

Anti-Xa Monitoring of Low-Molecular-Weight Heparin during Pregnancy: A Systematic Review.

Jun 17, 2021

Low-molecular-weight heparin (LMWH) is commonly used for preventing or treating venous thromboembolic disease (VTE) during pregnancy. The physiological changes in maternal metabolism have led to discu...

Potential Strategies to Increase Gynecologic Oncologist Treatment for Ovarian Cancer.

Jun 17, 2021

Evidence shows that treatment by gynecologic oncologists (GOs) increases overall survival among women with ovarian cancer. However, specific strategies for institutions and community-based public heal...

Real-world experience with trabectedin for the treatment of recurrent ovarian cancer.

Jun 17, 2021

: The efficacy and safety of trabectedin/pegylated liposomal doxorubicin (trabectedin/PLD) in patients with recurrent ovarian cancer have been demonstrated in randomized clinical studies. Real-world e...

[Clinical applications of bevacizumab in the treatment of colorectal and ovarian cancer.]

Jun 17, 2021

The development of biological drugs, which began in the 1980s, has revolutionized the treatment of numerous oncological diseases and severely disabling autoimmune diseases, with widely demonstrated ev...

LRH-1 high expression in the ovarian granulosa cells of PCOS patients.

Jun 17, 2021

Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders with heterogeneity. There are also reports that liver receptor homolog 1 [LRH-1 or nuclear receptor subfamily ...

Elevated Anti-Müllerian Hormone Levels in Newborns of Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis Based on Observational Studies.

Jun 17, 2021

We performed this updated systematic review and meta-analysis to evaluate anti-Müllerian hormone levels (AMH) in newborns of mothers with polycystic ovary syndrome (PCOS) compared with healthy contro...

Dissection of phospholipases A reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria.

Jun 17, 2021

Cationic peptides bio-inspired by natural toxins have been recognized as an efficient strategy for the treatment of different health problems. Due to the specific interaction with substrates from biol...

Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.

Jun 17, 2021

Breast cancer remains one of the leading cancers among women. Cancer stem cells (CSCs) are tumor-initiating cells which drive progression, metastasis, and reoccurrence of the disease. CSCs are resista...

Mat pilates method improve postural alignment women undergoing hormone therapy adjunct to breast cancer treatment. Clinical trial.

Jun 17, 2021

The purpose of the study is to analyze the effects of a mat Pilates intervention on the postural alignment and balance of breast cancer women receiving hormone therapy. A two-arm randomized clinical t...

Examining Long-Term Sexual Outcomes With Exstrophy-Epispadias

Jun 16, 2021

“For children with exstrophy-epispadias complex (EEC), a spectrum of genitourinary malformation, the clinical focus has typically been on reconstruction of the external genitalia and lower urinary t...

Safety and efficiency of modified sacrospinous ligament fixation for apical prolapse: Long-term studies and outcomes.

Jun 14, 2021

To explore the safety and efficiency of modified sacrospinous ligament fixation (MSSF) for apical prolapse.It's a retrospective cohort study. Patients diagnosed with apical prolapse from 2014 to 2019 ...

Safety of Dapagliflozin in Patients with Type 2 Diabetes Mellitus in Saudi Arabia: A Post Authorization Safety Study.

Jun 14, 2021

Sodium-glucose co-transporter-2 (SGLT2) inhibitors moderately reduce glucose levels in type-2 diabetes mellitus (T2DM). Some cases of diabetic ketoacidosis (DKA) were reported with SGLT2 inhibitors. H...

Impact of inappropriate empirical antibiotic treatment on clinical outcomes of urinary tract infections caused by Escherichia coli: a retrospective cohort study.

Jun 14, 2021

We aimed to determine the clinical impact of inappropriate empirical antibiotic treatment (IEAT) compared with appropriate empirical antibiotic treatment (AEAT) in hospitalised patients with urinary t...

SARS-CoV-2 infection during pregnancy and pregnancy-related conditions: Concerns, challenges, management and mitigation strategies-a narrative review.

Jun 14, 2021

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health problem. The SARS-CoV-2 triggers hyper-activ...

Fetal double outlet right ventricle without heterotaxy syndrome: diagnostic spectrum, associated extracardiac pathology and clinical outcomes.

Jun 14, 2021

To document the clinical spectrum and outcomes of fetal DORV without heterotaxy in a recent diagnostic era.Prenatal cases of DORV consecutively diagnosed from 2007-2018 were retrospectively identified...

The outcome of intra-cytoplasmic sperm injection (ICSI): do the sperm concentration and motility matter?

Jun 14, 2021

The male-factor subfertility was reported to be 30% globally; thus, the intracytoplasmic sperm injection (ICSI) procedure was implemented to improve the overall fertilization (IVF) rates. Nevertheles...

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the management of peritoneal surface malignancies - An evidence-based review.

Jun 14, 2021

Traditionally, peritoneal surface malignancies (PSM) were considered terminal diseases because of their advanced nature, therefore, systemic chemotherapy was given with palliative intent only. As a re...

COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells.

Jun 14, 2021

Ovarian cancer has a unique tumor microenvironment (TME) that enables cancer-associated fibroblasts (CAFs) to interact with cellular and matrix constituents and influence tumor development and migrati...

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