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OB/GYN General

Late/post-term decidual basalis-derived mesenchymal stem/stromal cells show evidence of advanced ageing and downregulation of microRNA-516b-5p.

May 13, 2021

The placenta is a short-lived organ, yet it shows signs of progressive ageing in the third trimester. Studies of ageing chorionic placental tissue have recently flourished, providing evidence of advan...

Cytogenetic Analysis of the Products of Conception After Spontaneous Abortion in the First Trimester.

May 13, 2021

In the present study, we retrospectively recruited 340 patients who underwent spontaneous abortions to investigate chromosomal abnormalities of the conception products in the first trimester. We also ...

Low-grade serous epithelial ovarian cancer: a comprehensive review and update for radiologists.

May 13, 2021

Low-grade serous carcinoma (LGSC) is an infrequent subtype of ovarian cancer, corresponding to 5% of epithelial neoplasms. This subtype of ovarian carcinoma characteristically has molecular features, ...

LncRNA FGD5-AS1 promotes the malignant phenotypes of ovarian cancer cells via targeting miR-142-5p.

May 13, 2021

Long non-coding RNAs (lncRNAs) have been reported to participate in regulating gene expression and are related to tumor progression. FGD5 antisense RNA 1 (FGD5-AS1) facilitates the progression of vari...

Pelvic Floor Muscle Dysfunctions in Women with Deep Infiltrative Endometriosis: An Underestimated Association.

May 13, 2021

Deep infiltrative endometriosis (DIE) may cause pelvic pain and thus negatively affect the function of different structures. We hypothesized that women with DIE may have dysfunctions of the pelvic flo...

Radiation without endocrine therapy in older women with stage I estrogen-receptor (ER) positive breast cancer is not associated with a higher risk of second breast cancer events.

May 13, 2021

The omission of radiation therapy (RT) in elderly women with stage 1 estrogen-receptor positive (ER+) breast cancer receiving endocrine therapy (ET) is an acceptable strategy based on randomized trial...

Part-time cancers and role of melatonin in determining their metabolic phenotype.

May 13, 2021

This brief review describes the association of the endogenous pineal melatonin rhythm with the metabolic flux of solid tumors, particularly breast cancer. It also summarizes new information on the pot...

The Impact of Platinum-Containing Chemotherapies in Advanced Triple-Negative Breast Cancer: Meta-Analytical Approach to Evaluating Its Efficacy and Safety.

May 13, 2021

Triple-negative breast cancer (TNBC), the most common type of breast cancer, is associated with poor patient prognosis. Platinum-containing chemotherapies are commonly used in the treatment and preven...

Physical Activity, Diet, and Incident Urinary Incontinence in Postmenopausal Women: Women's Health Initiative Observational Study.

May 10, 2021

Physical activity and macronutrient intake, important contributors to energy balance, may be independently associated with female urinary incontinence (UI).We evaluated the association of baseline sel...

Heterogeneity in outcome selection, definition and measurement in studies assessing the treatment of cryptoglandular anal fistula: findings from a systematic review.

May 10, 2021

Treatment for cryptoglandular anal fistula (AF) is challenging and a lack of uniform outcomes in the literature prevents direct comparison of treatments. This can be addressed by developing a core out...

Molecular characterization of ESBL- producing uropathogenic Escherichia coli recovered from urine samples of patients attending a University Teaching hospital in Nigeria.

May 10, 2021

Infection of the urinary tract ranks as one of the most common infections affecting people worldwide and its treatment is made complicated by the rising incidence of antibiotic resistance. This study ...

Longitudinal changes in HRV across pregnancy and postpartum: Effect of negative partner relationship qualities.

May 10, 2021

During pregnancy, there are significant physiological changes to support a healthy fetus. Parasympathetic activity normatively decreases across pregnancy, and psychological stress can promote even fur...

Side of ovulation at each end of two- and three-wave interovulatory intervals and before and after pregnancy in cattle.

May 10, 2021

The side of ovulation (left ovary, LO; right ovary, RO) and side of the next ovulation were compared between (1) beginning and end of an interovulatory interval (IOI) and beginning and end of consecut...

Maternal obesity and baseline vitamin D insufficiency alter the response to vitamin D supplementation: a double-blind, randomized trial in pregnant women.

May 10, 2021

The achievement of target 25-hydroxyvitamin D [25(OH)D] concentrations in pregnancy may be altered by maternal obesity.The authors examined the effects of maternal supplementation of 10 μg compared w...

WNT4 balances development versus disease in gynecologic tissues and women's health.

May 10, 2021

The WNT family of proteins are crucial in numerous developmental pathways and tissue homeostasis. WNT4, in particular, is uniquely implicated in development of the female phenotype in the fetus, and i...

[ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].

May 10, 2021

To investigate the expression of ENTPD5 in epithelial ovarian cancer and explore its clinical implications.The expression level of ENTPD5 in epithelial ovarian cancer was analyzed based on data from O...

Pre- and post-diagnosis leisure time physical activity and survival following diagnosis with ovarian cancer.

May 10, 2021

Little is known about the influence of pre- and post-diagnosis physical activity on ovarian cancer survival. We investigated this association in two large cohorts, the Nurses' Health Study (NHS) and N...

Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis.

May 10, 2021

Elagolix is a novel, oral gonadotropin-releasing hormone receptor antagonist indicated for the management of moderate to severe pain associated with endometriosis and heavy menstrual bleeding associat...

Alpelisib in combination with everolimus ± exemestane in solid tumours: Phase Ib randomised, open-label, multicentre study.

May 10, 2021

Combined mTORC1 inhibition with everolimus (EVE) and phosphatidylinositol 3-kinase catalytic subunit p110α blockade with alpelisib (ALP) has demonstrated synergistic efficacy in preclinical models an...

A transfer learning with structured filter pruning approach for improved breast cancer classification on point-of-care devices.

May 10, 2021

A significant progress has been made in automated medical diagnosis with the advent of deep learning methods in recent years. However, deploying a deep learning model for mobile and small-scale, low-c...

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