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OB/GYN General

[ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].

May 10, 2021

To investigate the expression of ENTPD5 in epithelial ovarian cancer and explore its clinical implications.The expression level of ENTPD5 in epithelial ovarian cancer was analyzed based on data from O...

Pre- and post-diagnosis leisure time physical activity and survival following diagnosis with ovarian cancer.

May 10, 2021

Little is known about the influence of pre- and post-diagnosis physical activity on ovarian cancer survival. We investigated this association in two large cohorts, the Nurses' Health Study (NHS) and N...

Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis.

May 10, 2021

Elagolix is a novel, oral gonadotropin-releasing hormone receptor antagonist indicated for the management of moderate to severe pain associated with endometriosis and heavy menstrual bleeding associat...

Alpelisib in combination with everolimus ± exemestane in solid tumours: Phase Ib randomised, open-label, multicentre study.

May 10, 2021

Combined mTORC1 inhibition with everolimus (EVE) and phosphatidylinositol 3-kinase catalytic subunit p110α blockade with alpelisib (ALP) has demonstrated synergistic efficacy in preclinical models an...

A transfer learning with structured filter pruning approach for improved breast cancer classification on point-of-care devices.

May 10, 2021

A significant progress has been made in automated medical diagnosis with the advent of deep learning methods in recent years. However, deploying a deep learning model for mobile and small-scale, low-c...

Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies.

May 10, 2021

Epidemiologic studies examining the relations between dairy product and calcium intakes and breast cancer have been inconclusive, especially for tumor subtypes.To evaluate the associations between int...

Knowledge, Attitudes, Behaviors of Women Related to Pregnancy, and Early Childhood Caries Prevention: A Cross-Sectional Pilot Study.

May 10, 2021

Health education interventions during pregnancy can influence maternal oral health (OH), maternal OH-behaviors and children's OH. Interventions that can be delivered at anytime and anywhere, for examp...

Addressing Obstetric Health Disparities among Refugee Populations: Training the Next Generation of Culturally Humble OB/GYN Medical Providers.

May 10, 2021

The burden of increasing obstetric morbidity and mortality in the United States disproportionately affects marginalized and vulnerable populations, including refugees. Many factors have been attribut...

HPV Vaccination Rates Suboptimal Within Ages 9 to 12 Years

May 06, 2021

TUESDAY, May 4, 2021 (HealthDay News) -- Despite increases since 2008, human papillomavirus (HPV) vaccination rates are suboptimal within ages 9 to 12 years, according to a study published online May ...

UVENTA urethral stents: Are we taking a step forward? The first clinical series.

May 06, 2021

To describe first clinical results in term of safety, complications and short term efficacy of temporary placement of UVENTA urethral stent in the treatment of urethral and bladder neck strictures.UVE...

Single-dose amikacin plus 7 days of amoxicillin/clavulanate to treat acute cystitis caused by extended-spectrum beta-lactamase-producing : A retrospective cohort study.

May 06, 2021

Treatment options for urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing organisms are limited other than carbapenem. Accordingly, clinicians should investigate ...

A retrospective study of risk factors for stress urinary incontinence 1 year after delivery in multiparous women.

May 06, 2021

Stress urinary incontinence (SUI) is a common postpartum disorder. In this study, we aim to identify the risk factors for SUI in multiparous women 1 year after delivery.A retrospective cohort study w...

Midwives' views on alcohol guidelines: A qualitative study of barriers and facilitators to implementation in UK antenatal care.

May 06, 2021

Midwives play an important role in health promotion and prevention of alcohol-related harm, but previous research has suggested that although most midwives report advising on abstinence, evidence exis...

Prior Term Birth Decreases the Risk of Preterm Birth in a Subsequent Twin Gestation.

May 06, 2021

 The aim of the study is to examine the association between the risk of preterm delivery among women with twin pregnancies and their obstetric history. We designed a retrospective cohort study of ...

Dihydroartemisinin regulates apoptosis, migration, and invasion of ovarian cancer cells via mediating RECK.

May 06, 2021

Dihydroartemisinin (DHA) possesses an inhibitory effect on ovarian cancer and promotes reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression in glioma cells. This study explored...

Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.

May 06, 2021

Ovarian cancer (OvCA) remains one of the most devastating malignancies, but treatment options are still limited. We report that amphiregulin (AREG) can serve as an effective and safe pharmacological t...

Cisatracurium inhibits the growth and induces apoptosis of ovarian cancer cells by promoting lincRNA-p21.

May 06, 2021

As a common muscle relaxant, cisatracurium has shown good antitumor effect on some tumors. Recent studies reported that cisatracurium could inhibit the progression of colon cancer by upregulating tumo...

Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases.

May 06, 2021

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) and steroid sulfatase (STS) are involved in the synthesis of the most potent estrogen in the human body, estradiol (E2). These enzymes are known to...

Surgical management of deep pelvic endometriosis in France: do we need to be a pelvic surgeon to deal with DPE?

May 06, 2021

Endometriosis is a common disease in women, which requires a medical and surgical approach. Surgical societies recommend a multidisciplinary management in tertiary referral centers. The objective of o...

Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis.

May 06, 2021

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Radiotherapy is an effective option for the treatment of TNBC; however, acquired radioresistance is a major challenge...

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