Apr 26, 2021

Veliparib (ABT-888) is a poly (ADP-ribose) polymerase (PARP) inhibitor in development for treatment of high-grade ovarian cancer or BRCA-mutated breast cancer in combination with carboplatin and pacli...

Apr 26, 2021

Despite many attempts to treat ovarian cancer, 13,940 individuals perish annually due to this disease worldwide. Chemotherapy is the main approach to ovarian cancer treatment, but the development of d...

Apr 26, 2021

Ovarian cancer (OC) is a gynecological malignancy with a poor prognosis and low survival rate. E2F2 is a transcription activator that plays an indispensable role in cell proliferation and cell cycle p...

Apr 26, 2021

An increased number of highly active regulatory T cells (Tregs) and macrophages has been found in peritoneal fluid from women with endometriosis. Here, we show that the level of Tregs-derived soluble ...

Apr 26, 2021

What are the genetic causes of oocyte maturation defects?A homozygous splicing variant (c.788 + 3A>G) in TATA-box binding protein like 2 (TBPL2) was identified as a contributory genetic factor ...

Apr 26, 2021

Natural product produced by plants has been the backbone for numerous anticancer agents. In the present work, natural bioactive thymol based 1,2,3-triazole hybrids have been synthesized and evaluated ...

Apr 26, 2021

Extracellular vesicles (EVs) are micro and nanoscale packages that circulate in all bodily fluids and play an important role in intercellular communication by shuttling biomolecules to nearby and dist...

Apr 23, 2021

Continued monitoring is critical, officials say Preliminary data from a U.S. CDC Covid-19 mRNA vaccine safety study show no obvious safety signals in close to 36,000 women vaccinated during pregnancy...

Apr 23, 2021

International study confirms link to worse outcomes Having Covid-19 during pregnancy was associated with worse outcomes, such as maternal mortality, preeclampsia, and preterm birth, in an internati...

Apr 22, 2021

Evidence regarding the impact of giant prostate volume (PV) on outcome after radical prostatectomy (RP) is controversial with a lack of evidence on the impact of PV on health-related quality of life (...

Apr 22, 2021

The aim of the study was to evaluate the genetic affinity of uropathogenic E. coli cultures (UPEC) and to identify the major types of extended spectrum beta-lactamases (ESBL) found among nosocomial is...

Apr 22, 2021

 This study aimed to assess the use of a standardized prenatal genetic testing educational video and its effects on patient uptake of prenatal testing, patient knowledge, decisional conflict, and de...

Apr 22, 2021

 Limited data are available on the outcome of infants born after uterus transplantation. Our aim was to describe the hospital course and laboratory findings in the first 2 months of life of the 12 i...

Apr 22, 2021

Describe the medium-term safety of the tension free vaginal tape obturator (TVT-O) procedure in terms of complications, cure and changes in quality of life (QoL) after the surgery.Descriptive historic...

Apr 22, 2021

Women with pathogenic variants in BRCA1/2 have a significantly increased lifetime risk of breast and ovarian cancers. The availability of genetic testing to identify BRCA1/2 carriers is imperative to ...

Apr 22, 2021

To investigate the relationship between lncRNA PVT1(PVT1) level and PD-L1 expression and their functions in cisplatin resistant epithelial ovarian cancer (CREOC).PVT1 and PD-L1 in ovarian cancer tissu...

Apr 22, 2021

Recent studies have revealed that myo-inositol could be more influential in patients with polycystic ovary syndrome (PCOS). This study was aimed to determine and compare the effects of myo-inositol an...

Apr 22, 2021

Reproductive health is a broad concept that encompasses mortality, morbidity, and quality of life associated with the reproductive system, mechanism, and incidents encountered at all ages by men and w...

Apr 22, 2021

The role of adjuvant chemotherapy (aCT) for patients with localized lobular breast cancer (ILC) is still controversial. It is unclear what is the magnitude of benefit of the CT in this setting. In thi...

Apr 22, 2021

Previous studies revealed that patients with early-stage metaplastic breast cancer (MBC) underwent mastectomy more often than breast-conserving therapy (BCT) mainly due to the larger tumor size. This ...