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OB/GYN General

Imbalance between inflammatory and regulatory cord blood B cells following pre-term birth.

Apr 15, 2021

Preterm birth (PTB) is one of the most frequent pregnancy complications. It affects millions of babies each year worldwide and is associated with increased morbidity and mortality. PTB-associated alte...

Protocol for The Pregnancy During the COVID-19 Pandemic (PdP) study: A longitudinal cohort study of mental health among pregnant Canadians during the COVID-19 pandemic and developmental outcomes in their children.

Apr 15, 2021

The COVID-19 pandemic and countermeasures implemented by governments around the world have led to dramatically increased symptoms of depression and anxiety. Pregnant women may be particularly vulnerab...

Generation of a three-dimensional in vitro ovarian cancer co-culture model for drug screening assays.

Apr 15, 2021

In vitro 3D culture models have emerged in the cancer field due to their ability to recapitulate characteristics of the in vivo tumor. Herein, we described the establishment and characterization of 3D...

Synergistic effects of green tea extract and Paclitaxel in the induction of mitochondrial apoptosis in ovarian cancer cell lines.

Apr 15, 2021

Green tea is a natural compound with anti-neoplastic properties. Paclitaxel (PTX) is a natural anti-tumor medication used to manage patients with advanced ovarian cancer. This manuscript evaluated the...

Multi-omics analysis of the prognosis and therapeutic significance of circadian clock in ovarian cancer.

Apr 15, 2021

Ovarian cancer (OV) is one of the most common female malignancies with high morbidity and mortality, but its mechanism is not fully understood. The circadian clock is involved in the regulation of the...

Gut Microbiota and Gynecological Cancers: A Summary of Pathogenetic Mechanisms and Future Directions.

Apr 15, 2021

Over the past 20 years, important relationships between the microbiota and human health have emerged. A link between alterations of microbiota composition (dysbiosis) and cancer development has been r...

Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice.

Apr 15, 2021

A remarkable feature of tissue stem cells is their ability to regenerate the structure and function of host tissue following transplantation. However, the dynamics of donor stem cells during regenerat...

Specific PIWI-interacting RNAs (piRNAs) and related small noncoding RNAs are associated with ovarian aging in Ames dwarf (df/df) mice.

Apr 15, 2021

The Ames dwarf (df/df) mouse is a well-established model for delayed aging. MicroRNAs (miRNAs), the most studied small noncoding RNAs (sncRNAs), may regulate ovarian aging to maintain a younger ovaria...

LncRNA-miRNA axes in breast cancer: Novel points of interaction for strategic attack.

Apr 15, 2021

Therapeutic effectiveness in breast cancer can be limited by the underlying mechanisms of pathogenesis, including epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and drug resistance....

Matairesinol, an active constituent of HC9 polyherbal formulation, exhibits HDAC8 inhibitory and anticancer activity.

Apr 15, 2021

Histone deacetylase 8 (HDAC8) has emerged as a promising drug target for cancer therapeutics development. HDAC8 has been reported to regulate cancer cell proliferation, invasion and promote metastasis...

Covid-19: Transmission Through Breast Milk Rare

Apr 14, 2021

No infected moms in Israeli case study passed virus to their newborns No infections occurred among 55 mostly breastfed neonates born to mothers with Covid-19 in a study from Israel, suggesting that...

Healthy Aging-Nutrition Matters: Start Early and Screen Often.

Apr 12, 2021

The amount of time spent in poor health at the end of life is increasing. This narrative review summarizes consistent evidence indicating that healthy dietary patterns and maintenance of a healthy wei...

Using an agent-based sexual-network model to analyze the impact of mitigation efforts for controlling chlamydia.

Apr 12, 2021

Chlamydia trachomatis (Ct) is the most reported sexually transmitted infection in the United States, with a major cause of infertility, pelvic inflammatory disease, and ectopic pregnancy among women. ...

Lymphocyte soluble factors from pregnant cows modulate mRNA transcript abundances encoding for proteins associated with trophoblast growth and development.

Apr 12, 2021

This study was conducted to determine whether T cell populations are responsible for modulating placental development during gestation in cattle. It was hypothesized that CD4+CD25+ and γ/δ+ T cells ...

Maternal exposure to ambient air pollution and congenital heart defects in China.

Apr 12, 2021

Evidence of maternal exposure to ambient air pollution on congenital heart defects (CHD) has been mixed and are still relatively limited in developing countries. We aimed to investigate the associatio...

Serum lipid profiling analysis and potential marker discovery for ovarian cancer based on liquid chromatography-Mass spectrometry.

Apr 12, 2021

Low early diagnosis rate and unclear pathogenesis are the primary reasons for the high mortality of epithelial ovarian cancer (EOC). Lipidomics is a powerful tool for marker discovery and mechanism ex...

Impact of national guidelines on use of BRCA1/2 germline testing, risk management advice given to women with pathogenic BRCA1/2 variants and uptake of advice.

Apr 12, 2021

This nationwide study assessed the impact of nationally agreed cancer genetics guidelines on use of BRCA1/2 germline testing, risk management advice given by health professionals to women with pathoge...

DNA damage response and PD-1/PD-L1 pathway in ovarian cancer.

Apr 12, 2021

Ovarian cancer has a poor prognosis due to drug resistance, relapse and metastasis. In recent years, immunotherapy has been applied in numerous cancers clinically. However, the effect of immunotherapy...

"Since I'm a little bit more mature": contraception and the arc of time for women in midlife.

Apr 12, 2021

Contraceptive methods have rapidly evolved over the past several decades, but little research has explored how women interact with contraception over time. Exploring contraceptive beliefs, perceptions...

Successful salvage of an infected breast prothesis by changing from continuous to intermittent suction under continuous irrigation.

Apr 12, 2021

Implant-based breast reconstruction is a widely performed procedure. However, prostheses are susceptible to infection and there are currently no established guidelines on treatment. In the present cas...

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