Apr 12, 2021

Triple-negative breast cancer (TNBC) has an unfavorable prognosis attribute to its low differentiation, rapid proliferation and high distant metastasis rate. PI3K/Akt/mTOR as an intracellular signalin...

Apr 12, 2021

Two promising therapeutic strategies in oncology are chimeric antigen receptor-T cell (CAR-T) therapies and antibody-drug conjugates (ADCs). To be effective and safe, these immunotherapies require sur...

Apr 12, 2021

The learning curve cumulative summation test (LC CUSUM test) allows to define an individualized learning curve and determine the moment when clinical proficiency is attained. After acquisition of the ...

Apr 09, 2021

Disclaimer: The thoughts and ideas in this post are Dr. Tuchler's alone and do not represent Kaiser Permanente’s positions, strategies, or opinions.   A tsunami is building. Even a...

Apr 08, 2021

After George Floyd’s death from a police officer kneeling on his neck, I began to reflect on how I can guide all my patients to be anti-racist. I decided to approach the topic in the same breath as ...

Apr 08, 2021

Urethral closure mechanism dysfunction in female stress urinary incontinence (SUI) is poorly understood. We aimed to quantify these mechanisms through changes in urethral shape and position during squ...

Apr 08, 2021

We studied a subset of patients with autopsy-confirmed multiple system atrophy who presented a clinical picture that closely resembled either Parkinson's disease or progressive supranuclear palsy. The...

Apr 08, 2021

The onset of labour is a culmination of a series of highly coordinated and preparatory physiological events that take place throughout the gestational period. In order to produce the associated contra...

Apr 08, 2021

The diverse nature of parenting among people with intellectual disabilities can be affected by many factors, including stereotypes, experiencing social isolation, living in poverty, suffering from chr...

Apr 08, 2021

Long non-coding RNAs (lncRNAs) have important biological functions, but their involvement in ovarian cancer remains elusive. We analyzed high-throughput data to identify lncRNAs associated with ovaria...

Apr 08, 2021

Mesenteric lymph node (MLN) involvement is often observed in ovarian cancer (OC) with rectosigmoid invasion. This study aimed to investigate the clinical significance of MLN involvement in the pattern...

Apr 08, 2021

We and other investigators have shown that platelets promote metastasis and the growth of tumors. Our rationale for conducting this study is that platelets' prometastatic and progrowth effects depend ...

Apr 08, 2021

Androgens have been reported to be associated with female fertility. The mean serum testosterone concentration in the patients with endometriosis was reported to be significantly lower than that witho...

Apr 08, 2021

Endometriosis is a common and complicated gynaecologic disease. Long non-coding RNA CDKN2B-AS1 plays a crucial role in the development and progression of several cancers. Whether CDKN2B-AS1 contribute...

Apr 08, 2021

What is the agreement between antral follicle count (AFC) and anti-Müllerian hormone (AMH) levels when used to patient classification according to the Patient-Oriented Strategies Encompassing Individ...

Apr 08, 2021

Photocatalytic removal of estrogenic compounds (ECs), 17β-estradiol (E2), and 17α-ethinylestradiol (EE2) were assessed using a TiO-ZnO nanocomposite (NC) over a range of initial EC concentration (C;...

Apr 08, 2021

Signet ring cell breast carcinoma (SRCBC) is a rare variant of invasive lobular carcinoma and there are no large series characterizing its long-term prognosis.The NCDB was queried from 2004-2016 to id...

Apr 08, 2021

HER-2 positive breast cancer has a high risk of for relapse, metastasis and drug resistance, and is related to a poor prognosis. Thus, the study objective was to determine a target gene and explore th...

Apr 08, 2021

Learners consistently report insufficient feedback, despite interventions to improve the quantity and quality of feedback. Effective feedback requires a dynamic partnership and a trusting relationship...

Apr 08, 2021

Medical students lack knowledge about the effects of bariatric surgery on pregnancy and medical management of obesity as it relates to reproductive health. Additionally, there is bias toward obese pat...