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OB/GYN General

Should we perform cervix removal during hysterectomy for benign uterine disease? Clinical practice guidelines from the French College of Gynecologists and Obstetricians (CNGOF).

Apr 05, 2021

To provide guidelines from the French College of Obstetricians and Gynecologists (CNGOF), based on the best evidence available, concerning subtotal or total hysterectomy, for benign disease.The CNGOF ...

Non-classic splicing mutation in the CPLANE1 (C5orf42) gene cause Joubert syndrome in a fetus with severe craniocerebral dysplasia.

Apr 05, 2021

Joubert syndrome is a rare neurodevelopmental disorder characterized by clinical and genetic heterogeneity. The characteristic molar tooth sign, resulted from cerebellar vermis hypoplasia and midbrain...

Effect of Heparanase and Heparan Sulfate Chains in Hemostasis.

Apr 05, 2021

Heparanase, the only mammalian enzyme known to degrade heparan sulfate chains, affects the hemostatic system through several mechanisms. Along with the degrading effect, heparanase engenders release o...

The Role of PBK as a Potential Prognostic and Diagnostic Biomarker in Ovarian Cancer.

Apr 05, 2021

As one of the three malignant genital tumors, mortality in women with ovarian cancer is consistently high worldwide. It is of great importance to find prognostic markers for diagnosis and treatment o...

Distribution of Serum Thrombospondin-2, a Novel Tumor Marker , in General Population and Cancer Patients in China.

Apr 05, 2021

Distribution of serum thrombospondin-2 in general population and cancer patients in China have not been reported.This study evaluated the expression level of serum thrombospondin-2 in general populati...

FGFR3 phosphorylates EGFR to promote cisplatin-resistance in ovarian cancer.

Apr 05, 2021

Ovarian cancer is a deadly gynecologic cancer, and the majority of patients with ovarian cancer experience relapse after traditional treatment. Cisplatin (DDP) is a common chemotherapeutic drug for ov...

Polycystic ovary syndrome and obesity: clinical aspects and nutritional management.

Apr 05, 2021

Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine and metabolic disorder characterized by androgen excess, oligo-anovulatory infertility, polycystic ovaries in ultrasound examination, ins...

Coping Strategies for Sexual Problems and Sexual Dysfunction Amongst Malay Women With Breast Cancer. A Qualitative Study.

Apr 05, 2021

Women' sexuality becomes complex after breast cancer diagnosis and sexual health is highly neglected in the management of the illness.To explore the coping and strategies to overcome sexuality problem...

Effects of Yoga on Phase Angle and Quality of Life in Patients with Breast Cancer: A Randomized, Single-Blind, Controlled Trial.

Apr 05, 2021

Phase angle (PA), a parameter that is obtained from body composition analysis, is an indicator of cellular health status. A lower PA in cancer patients can lead to a decrease in functional status and ...

Atlas of sentinel lymph nodes in early breast cancer using single-photon emission computed tomography: implication for lymphatic contouring.

Apr 05, 2021

to determine the localization of sentinel lymph nodes (SLNs) in a large cohort of patients with breast cancer and validate the European Society for Therapeutic Radiology and Oncology (ESTRO), Radiatio...

Expanding Lynch Syndrome Screening to Include Ovarian Cancer

Apr 02, 2021

Although the benefits of universal screening for colorectal cancer (CRC) and endometrial cancer (EC) are well known and supported by widespread consensus among major medical and specialty societies, t...

Vaginal Progesterone, 17-OHPC Show Efficacy in Preventing Preterm Birth

Apr 01, 2021

Efficacy best for women with short cervical length, scant evidence for oral progesterone For high-risk pregnancies, finding effective ways to prevent pre-term birth is a priority. Vaginal progesteron...

Risk of Antibiotic Treatment Failure in Premenopausal Women with Uncomplicated Urinary Tract Infection.

Apr 01, 2021

Acute uncomplicated urinary tract infections (UTIs) are among the most common indications for antibiotic prescriptions in otherwise healthy women. We compared the risk of treatment failure of antibiot...

Protective Effects of Reduced Glutathione and Ulinastatin on Xeno-transplanted Human Ovarian Tissue Against Ischemia and Reperfusion Injury.

Apr 01, 2021

Recently, transplantation of cryopreserved ovarian tissue is the method for fertility preservation for oncologic and nononcologic reasons. The main challenge of ovarian cryopreservation followed by tr...

Using simulation team training with human's factors components in obstetrics to improve patient outcome: A review of the literature.

Apr 01, 2021

to assess the evidence from multidisciplinary simulation team training in obstetrics that integrates human's factors components on patient outcome.It has been stated that simulation-based education ha...

A male with primary accessory breast carcinoma in an axilla is strongly suspected of having hereditary breast cancer.

Apr 01, 2021

We herein report on a male with primary accessory breast cancer in an axilla. A 75-year-old man first noticed a subcutaneous nodule about 2 cm in diameter in the area of his right axilla. The patient...

LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair.

Apr 01, 2021

PARP inhibitors induce DNA lesions, the repair of which are highly dependent on homologous recombination (HR), and preferentially kill HR- deficient cancers. However, cancer cells have developed sever...

Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction.

Apr 01, 2021

Synthetic lethality is a successful strategy employed to develop selective chemotherapeutics against cancer cells. Inactivation of RAD52 is synthetically lethal to homologous recombination (HR) defici...

Non-alcoholic fatty liver disease in polycystic ovary syndrome women.

Apr 01, 2021

To evaluate risk factors leading to non-alcoholic fatty liver disease (NAFLD) occurrence in polycystic ovarian syndrome (PCOS) women. A retrospective cohort study of a total of 586 women diagnosed wit...

Comparative Success of Recruitment Strategies for an Exercise Intervention Trial Among Women With Polycystic Ovary Syndrome: Observational Study.

Apr 01, 2021

Effective and efficient participant recruitment is a key determinant of the success of a research program. Previously reported recruitment strategies have displayed variable success rates in studies o...

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