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OB/GYN General

Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer.

Mar 15, 2021

Emerging data support the use of thymidine kinase 1 (TK1) activity as a prognostic marker and for monitoring of response in breast cancer (BC). The long-term prognostic value of TK1 kinetics during ne...

Comprehensive analysis of expression and prognostic value of the claudin family in human breast cancer.

Mar 15, 2021

Claudins (CLDN) are structural components of tight junctions that function in paracellular transport and maintain the epithelial barrier function. Altered expression and distribution of members of the...

One-Step vs Two-Step Screening: Which is Better for Gestational Diabetes?

Mar 12, 2021

More diagnoses with one-step, but no major change in outcomes One-step screening for gestational diabetes boosted diagnoses versus two-step screening but ultimately did not have a meaningful impact o...

App-Based Treatment in Primary Care for Urinary Incontinence: A Pragmatic, Randomized Controlled Trial.

Mar 11, 2021

Electronic application (app)-based treatment is promising for common diseases with good conservative management options, such as urinary incontinence (UI) in women, but its effectiveness compared with...

Self-Management for Men With Lower Urinary Tract Symptoms: A Systematic Review and Meta-Analysis.

Mar 11, 2021

Lower urinary tract symptoms are very common in older men. We conducted a systematic review and meta-analysis to evaluate the effects of self-management interventions on these symptoms.We included ran...

A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection.

Mar 11, 2021

Platelet-rich plasma (PRP) is the most innovative blood-derived product used in regenerative medicine. We aimed to investigate the therapeutic efficacy of PRP urethral sphincter injection for the mana...

The value of the portable fibrinogen measuring device-a case report of severe postpartum hemorrhage with obstetric disseminated intravascular coagulation.

Mar 11, 2021

Fibrinogen concentration is an important indicator of the treatment for obstetric disseminated intravascular coagulation (DIC). We present how using the fibrinogen measuring device could solve problem...

Ultrasonographic measurement of the transcerebellar diameter for gestational age estimation in the third trimester.

Mar 11, 2021

Ultrasonographic estimation of gestational age is done routinely by using fetal biometric parameters, such as the biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and head c...

Antithrombotic therapy to prevent recurrent pregnancy loss in antiphospholipid syndrome - what is the evidence?

Mar 11, 2021

Aspirin and heparin are widely used to reduce the risk of recurrent pregnancy loss in women with antiphospholipid syndrome. This practice is based on only a few intervention studies, and uncertainty r...

A bioinformatic analysis: the overexpression and clinical significance of FCGBP in ovarian cancer.

Mar 11, 2021

Fc fragment of IgG-binding protein (FCGBP) is differentially expressed in various tumors. However, the correlation between FCGBP and immune cell infiltration in ovarian cancer remains unclear. FCGBP e...

A biphasic response of polymerized Type 1 collagen architectures to dermatan sulfate.

Mar 11, 2021

Collagen I, the most abundant extracellular matrix (ECM) protein in vertebrate tissues provides mechanical durability to tissue microenvironments and regulates cell function. Its fibrillogenesis in bi...

R-catcher, a potent molecular tool to unveil the arginylome.

Mar 11, 2021

Protein arginylation is a critical regulator of a variety of biological processes. The ability to uncover the global arginylation pattern and its associated signaling pathways would enable us to ident...

Primary Ovarian Insufficiency in women with Addison's disease.

Mar 11, 2021

Primary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison's disease (AAD) than in the general population, but the...

The Effect of Leptin Receptor Gene Polymorphisms (R223Q and P1019P) in Susceptibility to Polycystic Ovarian Syndrome in Kurdish Women.

Mar 11, 2021

Polycystic ovary syndrome (PCOS) is the known endocrinopathy disorder in the reproductive phase of women's life. More than half of the women with PCOS suffer from obesity which impacts the ovarian fun...

A highly sensitive electrochemical microRNA-21 biosensor based on intercalating methylene blue signal amplification and a highly dispersed gold nanoparticles/graphene/polypyrrole composite.

Mar 11, 2021

Numerous clinical studies suggest that microRNAs (miRNAs) are indicative biomolecules for the early diagnosis of cancer. This work aims to develop a cost-effective and label-free electrochemical biose...

Role of dietary fat on obesity-related postmenopausal breast cancer: insights from mouse models and methodological considerations.

Mar 11, 2021

The increasing incidence rate of breast cancer in the last few decades is known to be linked to the upward trend of obesity prevalence worldwide. The consumption of high-fat diet in particular has bee...

A Newly Characterized Potentially Probiotic Strain, Lactobacillus brevis MK05, and the Toxicity Effects of its Secretory Proteins Against MCF-7 Breast Cancer Cells.

Mar 11, 2021

Among seven strains of lactic acid bacteria (LAB) isolated from traditional dairy products, a Lactobacillus strain was identified through 16S rRNA gene sequencing and tentatively designated as Lactob...

Placebo Response in Patients with Oral Therapy for Overactive Bladder: A Systematic Review and Meta-analysis.

Mar 08, 2021

The role of a placebo response in the management of overactive bladder (OAB) remains unclear.The aim of this review is to methodically study the placebo response extracted from the control arms of ran...

Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β-adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity.

Mar 08, 2021

Transient receptor potential melastatin 8 (TRPM8) channels may contribute to the pathophysiological bladder afferent hyperactivity, thus a TRPM8 antagonist would be a promising therapeutic target for ...

Biodegradable materials for surgical management of stress urinary incontinence: A narrative review.

Mar 08, 2021

Stress urinary incontinence (SUI) was managed with techniques such as colposuspension, autologous fascia sling and urethral bulking agents. The introduction of the mid-urethral polypropylene (PP) slin...

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