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OB/GYN General

E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/Caspase-1/IL-1β-mediated pyroptosis in endometriosis.

Mar 18, 2021

Endometriosis is an inflammation-dependent disease which shares similarities with malignant tumors including attachment and infiltration. Tripartite motif containing 24 (TRIM24) has been illustrated i...

How did women with breast cancer experience the first wave of the COVID-19 pandemic? A qualitative study.

Mar 18, 2021

The ongoing COVID-19 global pandemic is a stressful experience that is particularly likely to negatively affect cancer patients. The goal of this qualitative study was to explore how breast cancer pat...

Factors Influencing Mammography Uptake Following a Screening Intervention among Asian American Women: A Systematic Review.

Mar 18, 2021

Asian American women, both immigrant and US-born, are known to have low mammography screening rates. To reduce health disparities and address community health needs, we undertook a systematic review t...

Cross-Resistance and the Mechanisms of Cephalosporin-Resistant Bacteria in Urinary Tract Infections Isolated in Indonesia.

Mar 15, 2021

Urinary tract infection (UTI) by antibiotic-resistant strains has become increasingly problematic, with trends that differ from country to country. This study examined cross-resistance and the mechani...

First Evidence for Colonizing of Acanthamoeba T4 Genotype in Urinary Tracts of Patients with Recurrent Urinary Tract Infections.

Mar 15, 2021

Limited evidence about the presence of Acanthamoeba spp. in urine specimens collected from urinary catheters of the patients in the intensive care units persuaded our study. No evidence has been found...

Biomechanics of the urinary bladder: spontaneous contraction activity and micromotions related to accommodation.

Mar 15, 2021

Knowledge of the fundamental properties of the urinary bladder is required to better understand its pathological conditions. Research on the passive and active properties of the bladder during stretch...

Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders.

Mar 15, 2021

To determine the trajectories of platelet counts and the prevalence of gestational thrombocytopenia (<150 × 10/L) during normal pregnancies and pregnancies with complications, such as hypertensi...

Prenatal exposure to bisphenols affects pregnancy outcomes and offspring development in rats.

Mar 15, 2021

The objective of this study was to evaluate the effects of gestational exposure to low doses of bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF) on pregnancy outcomes and offspring developm...

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.

Mar 15, 2021

Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxici...

Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer.

Mar 15, 2021

Y box binding protein 1 (YB-1) is a multifunctional protein associated with tumor progression and the emergence of treatment resistance (TR). Here, we report an azopodophyllotoxin small molecule, SU05...

Gene expression in the angiopoietin/TIE axis is altered in peripheral tissue of ovarian cancer patients: A prospective observational study.

Mar 15, 2021

Clinical studies suggest altered systemic vascular biology in cancer patients. We assessed expression patterns of endothelial activation- and vascular leakage-related genes in tumor as well as in tumo...

Mutations in the desert hedgehog (DHH) gene in the disorders of sexual differentiation and male infertility.

Mar 15, 2021

To identify the contribution of mutations in the Desert Hedgehog (DHH) gene to the disorders of sexual differentiation (DSD) and male infertility.The study included a total 430 subjects, including 47 ...

Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer.

Mar 15, 2021

Emerging data support the use of thymidine kinase 1 (TK1) activity as a prognostic marker and for monitoring of response in breast cancer (BC). The long-term prognostic value of TK1 kinetics during ne...

Comprehensive analysis of expression and prognostic value of the claudin family in human breast cancer.

Mar 15, 2021

Claudins (CLDN) are structural components of tight junctions that function in paracellular transport and maintain the epithelial barrier function. Altered expression and distribution of members of the...

One-Step vs Two-Step Screening: Which is Better for Gestational Diabetes?

Mar 12, 2021

More diagnoses with one-step, but no major change in outcomes One-step screening for gestational diabetes boosted diagnoses versus two-step screening but ultimately did not have a meaningful impact o...

App-Based Treatment in Primary Care for Urinary Incontinence: A Pragmatic, Randomized Controlled Trial.

Mar 11, 2021

Electronic application (app)-based treatment is promising for common diseases with good conservative management options, such as urinary incontinence (UI) in women, but its effectiveness compared with...

Self-Management for Men With Lower Urinary Tract Symptoms: A Systematic Review and Meta-Analysis.

Mar 11, 2021

Lower urinary tract symptoms are very common in older men. We conducted a systematic review and meta-analysis to evaluate the effects of self-management interventions on these symptoms.We included ran...

A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection.

Mar 11, 2021

Platelet-rich plasma (PRP) is the most innovative blood-derived product used in regenerative medicine. We aimed to investigate the therapeutic efficacy of PRP urethral sphincter injection for the mana...

The value of the portable fibrinogen measuring device-a case report of severe postpartum hemorrhage with obstetric disseminated intravascular coagulation.

Mar 11, 2021

Fibrinogen concentration is an important indicator of the treatment for obstetric disseminated intravascular coagulation (DIC). We present how using the fibrinogen measuring device could solve problem...

Ultrasonographic measurement of the transcerebellar diameter for gestational age estimation in the third trimester.

Mar 11, 2021

Ultrasonographic estimation of gestational age is done routinely by using fetal biometric parameters, such as the biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and head c...

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