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OB/GYN General

S100A7 promotes the development of human endometriosis by activating NF-κB signaling pathway in endometrial stromal cells.

Mar 08, 2021

Endometriosis (EM) is a chronic inflammatory disease affecting women between ages of 23-42 years with a prevalence of 6% to 10%. S100A7, a member of the S100 protein family, has been implicated in p...

"The use of bisphosphonates to treat skeletal complications in solid tumours".

Mar 08, 2021

The skeleton is the most common site of secondary disease in breast cancer and prostate cancer, with up to 80% of patients with advanced disease developing bone metastases (BM). The proportion is also...

Identification of U83836E as a γ-glutamylcyclotransferase inhibitor that suppresses MCF7 breast cancer xenograft growth.

Mar 08, 2021

γ-Glutamylcyclotransferase (GGCT) is involved in glutathione homeostasis, in which it catalyzes the reaction that generates 5-oxoproline and free amino acids from γ-glutamyl peptides. Increasing evi...

Plasmodium infection inhibits triple negative 4T1 breast cancer potentially through induction of CD8 T cell-mediated antitumor responses in mice.

Mar 08, 2021

We previously reported that Plasmodium infection promotes antitumor immunity in a murine Lewis lung cancer. In this study, we investigated the effects of Plasmodium infection on the tumor inhibition a...

Comparing Compensation of U.S. Military Physicians and Civilian Physicians in Residency Training and Beyond.

Mar 08, 2021

Introduction  Resident physicians have a professional degree but are compensated less than other recently graduated professionals such as lawyers or nurse practitioners. The U.S. Military Healthcare...

Proteomic and bioinformatic profiling of neutrophils in CLL reveals functional defects that predispose to bacterial infections.

Mar 04, 2021

Patients with chronic lymphocytic leukemia (CLL) typically suffer from frequent and severe bacterial infections. Although it is well known that neutrophils are critical innate immune cells facilitatin...

The human urobiome.

Mar 04, 2021

Traditionally, the healthy urinary bladder has been considered to be sterile. Several teams have used metagenomic (DNA-dependent) and metaculturomic (culture-dependent) methods to debunk this longstan...

Urinary Incontinence, Body Mass Index, and Physical Activity in Young Women.

Mar 04, 2021

Current evidence suggests that overweight and obesity are important risk factors for urinary incontinence in women. However, little is known about the relationships between body mass index (BMI), phys...

Increasing trend of C-section deliveries in India: A comparative analysis between southern states and rest of India.

Mar 04, 2021

To examine the socio-demographic variations in overwhelming existence of C-section deliveries in south India, with a comparison to rest of India.This study analyses data collected from 51,136 mothers ...

Suicidal ideation and attempt in adolescents exposed to maternal smoking across pregnancy and childhood: A 20-year prospective cohort study.

Mar 04, 2021

Few studies investigated the association between maternal smoking during pregnancy and offspring suicide risk, none considering postnatal smoking exposure. We investigated associations between materna...

Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival.

Mar 04, 2021

Cellular immunity against tumor cells is highly dependent on antigen presentation by major histocompatibility complex class I (MHC-I) molecules. However, few published studies have investigated associ...

LncRNA HOXC-AS3 Suppresses the Formation of Mature miR-96 in Ovarian Cancer Cells to Promote Cell Proliferation.

Mar 04, 2021

HOXC-AS3 has been reported to be an oncogenic lncRNA in several types of cancer, while its role in ovarian cancer (OC) is unknown. This study aimed to explore the involvement of HOXC-AS3 in OC. The ex...

The PROMova study comparing active and passive use of patient-reported outcome measures in ovarian cancer follow-up: effect on patient-perceived involvement, satisfaction with care, and usefulness.

Mar 04, 2021

Patients with ovarian cancer often experience substantial health problems and side effects resulting in reduced quality of life (QoL). Different models of using patient-reported outcome measures (PROM...

Women with Type 1 diabetes (T1D) experience a shorter reproductive period compared with nondiabetic women: the Pittsburgh Epidemiology of Diabetes Complications (EDC) study and the Study of Women's Health Across the Nation (SWAN).

Mar 04, 2021

Evidence suggests that insulin deficiency and hyperglycemia may disrupt the female reproductive system's normal function, leading to delayed menarche and premature ovarian aging. We thus compared the ...

Dienogest versus continuous oral levonorgestrel/EE in patients with endometriosis: what's the best choice?

Mar 04, 2021

Combined oral contraceptives (COC) and progestogens are widely used for the treatment of endometriosis. The objective of the study is to compare the efficacy of dienogest 2 mg vs continuous oral lev...

Differential diagnosis of T2 hypointense masses in musculoskeletal MRI.

Mar 04, 2021

Many soft tissue masses have an indeterminate appearance on MRI, often displaying varying degrees and extent of T2 hyperintensity. However, a subset of neoplasms and tumor-like lesions may exhibit pro...

Application of robotic single-site surgery with optional additional port for endometriosis: a single institution's experience.

Mar 04, 2021

To evaluate the safety and feasibility of treating stage I-IV endometriosis patients with robotic single-site surgery (RSSS). A retrospective chart review was conducted on 334 patients with endometrio...

Breast cancer proliferation and deterioration-associated metabolic heterogeneity changes induced by exposure of bisphenol S, a widespread replacement of bisphenol A.

Mar 04, 2021

Exposure to bisphenol A (BPA) is considered to be associated with the increased incidence of breast cancer. As a widespread replacement of BPA, the effect of bisphenol S (BPS) on breast tumor programm...

Diagnostic accuracy of MRI textural analysis in the classification of breast tumors.

Mar 04, 2021

To investigate whether textural analysis (TA) of MRI heterogeneity may play a role in the clinical assessment and classification of breast tumors.For this retrospective study, patients with breast mas...

Prognostic Factors and Survival Outcomes among Patients with Breast Cancer and Brain Metastases at Diagnosis: A National Cancer Database Analysis.

Mar 04, 2021

The aim of this study was to assess for clinicopathologic and socioeconomic features that predict improved survival for patients with advanced breast cancer with synchronous brain metastases at diagno...

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