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OB/GYN General

The effects of empagliflozin versus metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome.

May 26, 2020

Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understoo...

A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction.

May 26, 2020

Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer, characterized by the lack of expression of estrogen receptor, progesterone receptor, and human epidermal growth facto...

In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies.

May 26, 2020

In this study, anti-proliferative effects of twenty-seven indeno[1,2-b]quinoxalin-11-one derivatives were investigated in three human cancer cell lines, namely: the colon cancer cell line HCT-116, the...

A multi-stakeholder approach in optimising patients' needs in the benefit assessment process of new metastatic breast cancer treatments.

May 26, 2020

There is a growing understanding as science evolves that different cancer types require different approaches to treatment evaluation, especially in the metastatic stages. The introduction of new metas...

CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity.

May 26, 2020

Epigenetic deregulation of gene transcription is central to cancer cell plasticity and malignant progression but remains poorly understood. We found that the uncharacterized epigenetic factor chromodo...

Prospective Comparison of Intraoperative Touch Imprint Cytology and Frozen Section Histology on Axillary Sentinel Lymph Nodes in Early Breast Cancer Patients.

May 26, 2020

Since the late 1970s, sentinel lymph node biopsy (SLNB) has been used for several solid malignancies to identify lymph node metastases. This procedure is associated with less surgical morbidity than c...

Access to infertility care in a low-resource setting: bridging the gap through resident and fellow education in a New York City public hospital.

May 26, 2020

Improving access to care is an issue at the forefront of reproductive medicine. We sought to describe how one academic center, set in the background of a large and diverse metropolitan city, cares for...

[Frequency of depression and burnout syndrome in Obstetrics and Ginecology residents].

May 26, 2020

According to the World Health Organization, depression is the most prevalent mental disorder and burnout syndrome can occur among individuals whose work involves care or assistance to people, and, giv...

Current Trends in Compensation for Fellowship in Minimally Invasive Gynecologic Surgery (FMIGS) Graduates: A 6 Year Follow Up.

May 26, 2020

To present updated information regarding compensation patterns for FMIGS graduated physicians in the United States beginning practice during the last ten years, focusing on variables impacting differe...

Trends in Obesity-Associated Cancers

May 19, 2020

Research has shown that obesity accelerates the development of certain cancers, including cancers of the digestive tract, gynecologic cancers, and multiple myeloma. I led a team of researchers from th...

Intracerebral hematoma at the basal ganglia following lumbar puncture.

May 12, 2020

In patients with normal pressure hydrocephalus (NPH), lumbar puncture (LP) is an effective method for assessing both the diagnosis as well as the possible efficacy of ventriculoperitoneal shunting bas...

Extirpative cultures reveal infectious pubic bone osteomyelitis in prostate cancer survivors with urinary-pubic symphysis fistulae (UPF).

May 12, 2020

To examine the infectious features of patients with urinary pubic symphysis fistula (UPF) and their association with osteomyelitis.We conducted a review of our quality improvement database for 36 pati...

Outpatient fluoroquinolone prescribing patterns before and after US FDA boxed warning.

May 12, 2020

Fluoroquinolones are routinely overprescribed for uncomplicated urinary tract infection (uUTI), acute sinusitis, and acute bronchitis. In 2016, the United States (US) Food and Drug Administration (FDA...

Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility.

May 12, 2020

Carbonic anhydrase II (CA-II) knockout mice (Car2)have depleted numbers of renal intercalated cells which are increasingly recognized to be innate immune effectors. We compared pyelonephritis suscepti...

A Multifaceted Antimicrobial Stewardship Program for the Treatment of Uncomplicated Cystitis in Nursing Home Residents.

May 12, 2020

Urinary tract infections are the most common infections in nursing home residents. However, most antibiotic use is for unlikely cystitis (ie, nonspecific symptoms and positive culture results secondar...

Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex.

May 12, 2020

Herpesviruses acquire their membrane envelopes in the cytoplasm of infected cells via a molecular mechanism that remains unclear. Herpes simplex virus (HSV)-1 proteins pUL7 and pUL51 form a complex re...

Hepatitis C Virus Infection and Treatment as Independent Prognostic Factors in Diffuse Large B-Cell Lymphoma Egyptian Patients.

May 12, 2020

Egypt is one of highest hepatitis C virus (HCV) endemic areas. Chronic HCV infection has extra-hepatic manifestations, including non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is co...

Hepatitis C Screening Rates and Care Cascade in a Large US Insured Population, 2010-2016: Gaps to Elimination.

May 12, 2020

Understanding the health care system's ability to move patients through the hepatitis C virus (HCV) care cascade from screening to treatment is essential for HCV elimination. This retrospective study ...

Population-based study of autoimmune hepatitis and primary biliary cholangitis in Germany: rising prevalences based on ICD codes, yet deficits in medical treatment.

May 12, 2020

 Population-based data on the prevalence of and real-life treatment for the autoimmune liver diseases (AILD), primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), are scarce, and such k...

Successful fourth line treatment of a relapse patient with chronic hepatitis C virus infection genotype 3a using sofosbuvir, glecaprevir/pibrentasvir, and ribavirin: a case report.

May 12, 2020

 Relapses after therapy with direct-acting antiviral agents (DAA) in chronic hepatitis C virus (HCV) infections are rare due to high efficacy of interferon-free therapy regimens. The presence of res...

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