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OB/GYN General

Prognostic significance of elevated pretreatment serum levels of CEA and CA-125 in epithelial ovarian cancer.

May 12, 2020

Epithelial ovarian cancer is a highly lethal gynecological malignancy. Accurate and cost-effective predictive tools to estimate the prognosis of patients with epithelial ovarian cancer before treatmen...

Heterogeneity of immune microenvironment in ovarian cancer and its clinical significance: a retrospective study.

May 12, 2020

Treatment of ovarian cancer (OC) remains the biggest challenge among gynecological malignancies. Immune checkpoint blockade therapy is promising in many cancers but shows low response rates in OC beca...

Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents.

May 12, 2020

The anticancer, antimicrobial and antiplasmodial activities of six gold(iii) bis(dithiolene) complexes were studied. Complexes 1-6 showed relevant anticancer properties against A2780/A2780cisR ovarian...

Combined CCNE1 high-level amplification and overexpression is associated with unfavourable outcome in tubo-ovarian high-grade serous carcinoma.

May 12, 2020

CCNE1 amplification is a recurrent alteration associated with unfavourable outcome in tubo-ovarian high-grade serous carcinoma (HGSC). We aimed to investigate whether immunohistochemistry (IHC) can be...

Strategic combination therapies for ovarian cancer.

May 12, 2020

Ovarian cancer remains the leading cause of gynecologic cancer-related death among women worldwide. The dismal survival rate is partially due to recurrence after standardized debulking surgery and fir...

Use of a shaving technique for surgical management of partial ureteral obstruction due to endometriosis.

May 12, 2020

To illustrate the surgical management of advanced endometriosis causing extrinsic ureteral compression.Video description of the case, demonstration of the surgical technique, reevaluation at 14-year f...

Can environmental pollutant bisphenol A increase metabolic risk in polycystic ovary syndrome?

May 12, 2020

Bisphenol A (BPA), a widespread industrial substance is recognized as endocrine disrupting chemical and therefore could be associated with polycystic ovary syndrome (PCOS) related metabolic disturbanc...

Pathophysiological implications of hypoxia in human diseases.

May 12, 2020

Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution of enzymatic reactions...

Molecular and Functional Characterization of Inhibitor of Apoptosis Proteins (IAP, BIRP) in .

May 12, 2020

The larval stage of sensu lato, resulting in cystic echinococcosis, a parasitic zoonosis, causes huge economic losses to the livestock industry and poses a threat to public health. Inhibitor of apopt...

Cellular Plasticity in Breast Cancer Progression and Therapy.

May 12, 2020

With the exception of non-melanoma skin cancer, breast cancer is the most frequently diagnosed malignant disease among women, with the majority of mortality being attributable to metastatic disease. T...

Description of Druglike Properties of Safranal and Its Chemistry behind Low Oral Exposure.

May 12, 2020

Safranal, a plant secondary metabolite isolated from saffron, has been reported for several promising pharmacological properties toward the management of Alzheimer's disease. In the present study, we ...

Circ_0000526 Blocks the Progression of Breast Cancer by Sponging miR-492.

May 12, 2020

Breast cancer is one of the leading causes of cancer-associated death. This work aimed to explore the expression, function, and mechanism of circ_0000526 on the progression of breast cancer. The expre...

Postmastectomy Radiotherapy: Barriers to Implementation in a Disparate Population.

May 12, 2020

Appalachian Kentucky (AK) has a disproportionally high breast cancer mortality rate. Postmastectomy radiotherapy (PMRT) in N2/N3 nodal disease improves survival and locoregional recurrence. We evaluat...

Long Non-coding NR2F1-AS1 is Associated with Tumor Recurrence in Estrogen Receptor-positive breast cancers.

May 12, 2020

The tenacity of late recurrence of estrogen receptor (ER)-positive breast cancer remains a major clinical issue to overcome. The administration of endocrine therapies within the first 5 years substant...

Evaluating Shared Decision Making in Trial of Labor After Cesarean Counseling Using Objective Structured Clinical Examinations.

May 12, 2020

Although shared decision making (SDM) is optimal for trial of labor after cesarean (TOLAC) counseling, resources to assess residents' clinical competency and communication skills are lacking. We addre...

Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?

May 12, 2020

In the Look AHEAD trial, randomization to Intensive Lifestyle Intervention (ILI) or Diabetes Support and Education (DSE) did not result in differences in cognitive outcomes. However, menopause and APO...

[The status of menopause outpatient clinics in maternal and children health institutions and general hospitals in 11 provinces of China].

May 12, 2020

To understand the status of menopause outpatient clinics in maternal and children health (MCH) institutions and general hospitals. A total of 314 health administrative departments, MCH health instit...

Cervical Cancer Associated Biomarkers of Identify High Risk of Venous Thrombosis.

May 12, 2020

Our study aims to assess the validity of thrombotic biomarkers in estimation of venous thrombosis risk in cervical cancer patients.A total of 134 cervical cancer patients treated in our hospital from ...

It is all in the name: The importance of correct terminology in hormone replacement therapy.

May 12, 2020

The global increase in life expectancy to 74 years for women, while the median age of the menopause remains at 51 years, means that an increasing number of women will live a significant portion of the...

Sex-Specific Differences in Life Span Brain Volumes in Multiple Sclerosis.

May 12, 2020

Numerous sex-specific differences in multiple sclerosis (MS) susceptibility, disease manifestation, disability progression, inflammation, and neurodegeneration have been previously reported. Previous ...

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