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Ovarian Cancer

Wilms' tumor 1 antigen immunoreactivity in epithelial ovarian cancer - diagnostic and prognostic value.

Sep 24, 2020

Ovarian cancer is a heterogeneous disease, with a number of different histological subtypes with various responses to treatment. Wilms' tumor 1 (WT1) immunoreactivity is used to distinguish between OC...

CD122-selective IL-2 complexes reduce immunosuppression, promote Treg fragility, and sensitize tumor response to PD-L1 blockade.

Sep 21, 2020

The IL-2 receptor (IL-2R) is an attractive cancer immunotherapy target that controls immunosuppressive T regulatory cells (Tregs) and anti-tumor T cells. Here we used IL-2Rβ-selective IL-2/anti-IL-2 ...

Clear cell carcinoma of the ovary: a clinical and molecular perspective.

Sep 21, 2020

Clear cell carcinoma of the ovary has distinct biology and clinical behavior. There are significant geographical and racial differences in the incidence of clear cell carcinoma compared with other epi...

Tanapoxvirus: From discovery towards oncolytic immunovirotherapy.

Sep 17, 2020

Insufficiency of standard cancer therapeutic agents and a high degree of toxicity associated with chemotherapy and radiotherapy have created a dearth of therapeutic options for metastatic cancers. Onc...

Hyperthermic intraperitoneal chemotherapy in interval debulking surgery for advanced epithelial ovarian cancer: A single-center, real-life experience.

Sep 17, 2020

An improvement in survival without increasing perioperative morbidity in patients with advanced epithelial ovarian cancer treated with hyperthermic intraperitoneal chemotherapy (HIPEC) after interval ...

Challenges for immunotherapy for the treatment of platinum resistant ovarian cancer.

Sep 17, 2020

Platinum resistant ovarian cancer, usually defined as progression occurring within 6 months after completing platinum-based therapy, is a heterogeneous disease with poor prognosis and short survival (...

LncRNA LINC00857 regulates the progression and glycolysis in ovarian cancer by modulating the Hippo signaling pathway.

Sep 14, 2020

Ovarian cancer is one of the most common gynecological cancers with high morbidity and mortality, which seriously endangers women's health and quality of life. Long noncoding RNAs (lncRNAs) can regula...

A comprehensive genetic and epidemiological association analysis of vitamin D with common diseases/traits in the UK Biobank.

Sep 14, 2020

Vitamin D has been intensively studied for its association with human health, but the scope of such association and the causal role of vitamin D remain controversial. We aim to comprehensively investi...

Assessing the predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors.

Sep 14, 2020

We investigated N-hydroxy l-Arginine (NOHA) predictive response in serous ovarian carcinoma based on estrogen-hormone receptor expression status; and assessed the distinctive NOHA response between est...

Impact of Ki-67 Labeling Index on Prognostic Significance of the Chemotherapy Response Score in Women With Tubo-ovarian Cancer Treated With Neoadjuvant Chemotherapy.

Sep 10, 2020

The chemotherapy response score (CRS) proposed by Bohm and colleagues in 2015 has been validated as a reproducible method for determining histopathologic response of tubo-ovarian carcinoma to neoadjuv...

N-Glycome changes reflecting resistance to platinum-based chemotherapy in ovarian cancer.

Sep 10, 2020

A number of studies have reported aberrant glycosylation in connection with malignancy. Our investigation further expands on this topic through the examination of N-glycans, which could be associated ...

Age-related copy number variations and expression levels of F-box protein FBXL20 predict ovarian cancer prognosis.

Sep 10, 2020

About 70% of ovarian cancer (OvCa) cases are diagnosed at advanced stages (stage III/IV) with only 20-40% of them survive over 5 years after diagnosis. A reliably screening marker could enable a par...

Nurse-led follow-up in survivorship care of gynaecological malignancies-A randomised controlled trial.

Sep 07, 2020

To assess clinical and psychosocial outcomes of nurse-led follow-up in survivorship care of gynaecological malignancies.Women with endometrial or ovarian cancer who were attending regular post-treatme...

Confirming whether novel rhein derivative 4a induces paraptosis-like cell death by endoplasmic reticulum stress in ovarian cancer cells.

Sep 07, 2020

Ovarian cancer is the leading cause of death among gynecologic cancer patients. Although platinum-based chemotherapy as a frontline treatment for ovarian cancer has been widely used in clinical settin...

Identification of a prognostic signature of epithelial ovarian cancer based on tumor immune microenvironment exploration.

Sep 07, 2020

This study aims to develop an immune-related genes (IRGs) prognostic signature to stratify the epithelial ovarian cancer (EOC) patients. We identified 332 up- and 154 down-regulated EOC-specific IRGs....

Metformin inhibits the growth of ovarian cancer cells by promoting the Parkin-induced p53 ubiquitination.

Sep 03, 2020

Ovarian cancer is the most lethal diseases among women. The chemo-resistance has been a big challenge for the cancer treatment. It has been reported that metformin may inhibit ovarian cancer and is ab...

METTL3 regulates m6A in endometrioid epithelial ovarian cancer independently of METTl14 and WTAP.

Sep 03, 2020

N6-methyladenosine (m6A) RNA methylation, one of the common RNA modifications, has been determined to execute crucial functions on tumorigenesis and cancer development. The m6A "writers" including Met...

New approaches for targeting platinum-resistant ovarian cancer.

Sep 03, 2020

Platinum is the backbone of systemic treatment in ovarian cancer and development of platinum resistance is associated with poor survival. Here, we perform a comprehensive review of the literature rega...

Multisite Tumor Sampling Reveals Extensive Heterogeneity of Tumor and Host Immune Response in Ovarian Cancer.

Aug 31, 2020

Ovarian cancer (OVCA) is characterized by genomic/molecular intra-patient heterogeneity (IPH). Tissue histology and morphological features are surrogates of the underlying genomic/molecular contexture...

Endothelin-1 axis fosters YAP-induced chemotherapy escape in ovarian cancer.

Aug 31, 2020

The majority of ovarian cancer (OC) patients recur with a platinum-resistant disease. OC cells activate adaptive resistance mechanisms that are only partially described. Here we show that OC cells can...

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