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Ovarian Cancer

Disregulations of PURPL and MiR-338-3p Could Serve As Prognosis Biomarkers for Epithelial Ovarian Cancer.

Aug 19, 2021

The present study aimed to explore the expressions of long noncoding RNA (lncRNA) p53 upregulated regulator of p53 levels (PURPL) in different ovarian tissues, and to evaluate the significance of dis...

A Photoacoustic Contrast Agent for miR-21 via NIR Fluorescent Hybridization Chain Reaction.

Aug 19, 2021

Nucleic acids are well-established biomarkers of cancer with immense value in diagnostics and basic research. However, strategies to monitor these species in tissue can be challenging due to the need ...

CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance.

Aug 19, 2021

Despite wide use of anti-vascular endothelial growth factor (VEGF) therapy for many solid cancers, most individuals become resistant to this therapy, leading to disease progression. Therefore, new bio...

Clinical indicators useful in decision-making about palliative chemotherapy for end-of-life ovarian cancer patients.

Aug 05, 2021

Chemotherapy for end-of-life ovarian cancer patients is a complex and delicate problem. We evaluated whether active palliative chemotherapy is beneficial for such patients using inflammatory parameter...

Factors impacting the time to ovarian cancer diagnosis based on classic symptom presentation in the United States.

Aug 05, 2021

Patients with ovarian cancer often present with late-stage disease and nonspecific symptoms, but little is known about factors affecting the time to diagnosis (TTD) in the United States.A retrospectiv...

Lapatinib and poziotinib overcome ABCB1-mediated paclitaxel resistance in ovarian cancer.

Aug 05, 2021

Conventional frontline treatment for ovarian cancer consists of successive chemotherapy cycles of paclitaxel and platinum. Despite the initial favorable responses for most patients, chemotherapy resis...

Inherited Mutations in Men Undergoing Multigene Panel Testing for Prostate Cancer: Emerging Implications for Personalized Prostate Cancer Genetic Evaluation.

Jun 28, 2021

Multigene panels are commercially available for the evaluation of prostate cancer (PCA) predisposition, which necessitates tailored genetic counseling (GC) for men. Here we describe emerging results o...

NUT Carcinoma in the Pelvic Cavity With Unusual Pathologic Features.

Jun 28, 2021

NUT carcinoma is an aggressive epithelial malignancy defined by NUTM1 translocation, usually arising in the head/neck or thorax regions and showing squamous differentiation. Herein, we describe an ext...

The lncRNA 'UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels.

Jun 24, 2021

Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due to late diagnosis and resistance to chemotherapy, the 5-year survival rate in patients with OC is below 40%....

Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.

Jun 24, 2021

High-grade serous tubo-ovarian carcinoma (HGSC) is a major cause of cancer-related death. Treatment is not uniform, with some patients undergoing primary debulking surgery followed by chemotherapy (PD...

CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.

Jun 24, 2021

Platinum sensitivity is an important prognostic factor in patients with ovarian cancer. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a core member of the nucleosome remodeling and deacetylase...

Exploring Healthcare Super-Utilization in Gynecologic Oncology

Jun 18, 2021

Unplanned acute care continues to be a major contributor to growing healthcare costs in the United States, especially among patients with cancer. Quality measures have been developed to reduce healthc...

Heat shock protein 27 (hsp27) in patients with ovarian cancer.

Jun 10, 2021

Ovarian cancer remains a very common cause of death among women worldwide. The cause is to be found in too late of a diagnostic process and therapeutic difficulties The presence of heat shock proteins...

What matters to you? An investigation of patients' perspectives on and acceptability of prehabilitation in major cancer surgery.

Jun 10, 2021

To understand perspectives on and acceptability of prehabilitation among patients undergoing complex abdominal cancer surgery (cytoreductive surgery with or without hyperthermic intraperitoneal chemot...

The role of interpretation biases and symptom burden in fear of cancer recurrence/progression among ovarian cancer survivors.

Jun 10, 2021

Models of fear of cancer recurrence or progression (FCR/P) suggest that the way in which people interpret ambiguous physical symptoms is an important contributor to the development and maintenance of ...

Advanced Ovarian Cancer: Identifying Opportunities for Prehabilitation

Jun 04, 2021

Patients with epithelial ovarian cancer most commonly present when their disease has reached an advanced stage. “While primary cytoreductive surgery is a treatment option for some patients, others...

Paraneoplastic Cerebellar Degeneration (PCD) associated with PCA-1 antibodies in established cancer patients.

Jun 03, 2021

Paraneoplastic cerebellar degeneration (PCD) is a rare set of neurological disorders arising from tumor-associated autoimmunity against antigens within the cerebellum. Anti-Purkinje cell cytoplasmic a...

CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.

Jun 03, 2021

Ovarian cancer (OC) is the fifth leading cause of cancer death in women and one of the most prevalent malignancies in humans. Therefore, improved methods for OC early detection are urgently needed. Re...

Clinical efficacy analysis of Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with Paclitaxel-Cisplatin Chemotherapy in patients with Advanced Ovarian Cancer.

Jun 03, 2021

To explore the efficacy and safety of dendritic cell-cytokine induced killer cell (DC-CIK) immunotherapy combined with paclitaxel-cisplatin chemotherapy in the treatment of advanced ovarian cancer.Pat...

Long-term response on letrozole for gastric cancer: A case report.

May 27, 2021

Hormone therapies, particularly those targeting estrogen and its receptors, are a key treatment modality for patients with estrogen receptor (ER)-positive breast or ovarian cancer. Some gastric cancer...

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