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Ovarian Cancer

Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.

Jun 24, 2021

High-grade serous tubo-ovarian carcinoma (HGSC) is a major cause of cancer-related death. Treatment is not uniform, with some patients undergoing primary debulking surgery followed by chemotherapy (PD...

CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.

Jun 24, 2021

Platinum sensitivity is an important prognostic factor in patients with ovarian cancer. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a core member of the nucleosome remodeling and deacetylase...

Exploring Healthcare Super-Utilization in Gynecologic Oncology

Jun 18, 2021

Unplanned acute care continues to be a major contributor to growing healthcare costs in the United States, especially among patients with cancer. Quality measures have been developed to reduce healthc...

Heat shock protein 27 (hsp27) in patients with ovarian cancer.

Jun 10, 2021

Ovarian cancer remains a very common cause of death among women worldwide. The cause is to be found in too late of a diagnostic process and therapeutic difficulties The presence of heat shock proteins...

What matters to you? An investigation of patients' perspectives on and acceptability of prehabilitation in major cancer surgery.

Jun 10, 2021

To understand perspectives on and acceptability of prehabilitation among patients undergoing complex abdominal cancer surgery (cytoreductive surgery with or without hyperthermic intraperitoneal chemot...

The role of interpretation biases and symptom burden in fear of cancer recurrence/progression among ovarian cancer survivors.

Jun 10, 2021

Models of fear of cancer recurrence or progression (FCR/P) suggest that the way in which people interpret ambiguous physical symptoms is an important contributor to the development and maintenance of ...

Advanced Ovarian Cancer: Identifying Opportunities for Prehabilitation

Jun 04, 2021

Patients with epithelial ovarian cancer most commonly present when their disease has reached an advanced stage. “While primary cytoreductive surgery is a treatment option for some patients, others...

Paraneoplastic Cerebellar Degeneration (PCD) associated with PCA-1 antibodies in established cancer patients.

Jun 03, 2021

Paraneoplastic cerebellar degeneration (PCD) is a rare set of neurological disorders arising from tumor-associated autoimmunity against antigens within the cerebellum. Anti-Purkinje cell cytoplasmic a...

CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.

Jun 03, 2021

Ovarian cancer (OC) is the fifth leading cause of cancer death in women and one of the most prevalent malignancies in humans. Therefore, improved methods for OC early detection are urgently needed. Re...

Clinical efficacy analysis of Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with Paclitaxel-Cisplatin Chemotherapy in patients with Advanced Ovarian Cancer.

Jun 03, 2021

To explore the efficacy and safety of dendritic cell-cytokine induced killer cell (DC-CIK) immunotherapy combined with paclitaxel-cisplatin chemotherapy in the treatment of advanced ovarian cancer.Pat...

Long-term response on letrozole for gastric cancer: A case report.

May 27, 2021

Hormone therapies, particularly those targeting estrogen and its receptors, are a key treatment modality for patients with estrogen receptor (ER)-positive breast or ovarian cancer. Some gastric cancer...

Applying Artificial Intelligence to Gynecologic Oncology: A Review.

May 27, 2021

Artificial intelligence (AI) will play an increasing role in health care. In gynecologic oncology, it can advance tailored screening, precision surgery, and personalized targeted therapies.The aim of ...

Visualization of Necroptotic Cell Death through Transmission Electron Microscopy.

May 27, 2021

Transmission electron microscopy (TEM) is an all-in-one tool to visualize the complex systems of any specimen that is 1 nm in size or smaller. The current chapter provides detailed guidelines for ima...

Identifying novel ovarian tumor biomarkers through mining of the transcriptome of circulating immune cells: A proof-of-concept study.

May 24, 2021

Treatment of high-grade serous ovarian cancer (HGSOC) will benefit from early detection of the cancer. Here, we provide proof-of-concept data supporting the hypothesis that circulating immune cells, b...

Robotic-Assisted Extraperitoneal Paraaortic Lymphadenectomy is Associated with Fewer Surgical Complications: A Post-hoc Analysis of the STELLA-2 randomized trial.

May 24, 2021

To evaluate if extraperitoneal paraaortic lymphadenectomy using a robotic-assisted approach was associated with fewer complications when compared to all other approaches (conventional laparoscopic tra...

Towards population-based genetic screenings for breast and ovarian cancer: A comprehensive review from economic evaluations to patient perspectives.

May 24, 2021

Genetic testing for hereditary breast and ovarian cancer following genetic counseling is based on guidelines that take into account particular features of the personal and family history, and clinical...

Long non-coding RNA-H19 promotes ovarian cancer cell proliferation and migration via the microRNA-140/Wnt1 axis.

May 20, 2021

To explore the effect and underlying molecular mechanism of long non-coding RNA (lncRNA)-H19 on ovarian cancer (OC) cells, a total of 41 cases of OC and adjacent normal tissues were collected. H19 and...

Risks of subsequent primary cancers among breast cancer survivors according to hormone receptor status.

May 20, 2021

This study was aimed at examining the risks of subsequent primary cancers (SPCs) among breast cancer survivors by hormone receptor (HR) status and age at diagnosis.Data from 12 Surveillance, Epidemiol...

hTERT-molecular targeted therapy of ovarian cancer cells via folate-functionalized PLGA nanoparticles co-loaded with MNPs/siRNA/wortmannin.

May 20, 2021

Effective telomerase-molecular targeted cancer therapy might be a promising approach for the efficient treatment of ovarian cancer. Therefore, folate-functionalized PLGA nanoparticles (NPs) were co-lo...

Nano-assembly of ursolic acid with platinum prodrug overcomes multiple deactivation pathways in platinum-resistant ovarian cancer.

May 06, 2021

As the most common cause of gynecological cancer-related deaths worldwide, ovarian cancer requires novel therapy strategies. Pt(ii)-Based antitumor drugs (e.g. cisplatin) are one of the most successfu...

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