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Ovarian Cancer

Dietary Vitamin K Intake and the Risk of Pancreatic Cancer: A Prospective Study of 101695 American Adults.

May 06, 2021

No epidemiological studies have been conducted to assess the association of dietary vitamin K intake with the risk of pancreatic cancer. We used prospective data from the Prostate, Lung, Colorectal, a...

Conditional disease-free survival rates and their associated determinants in patients with epithelial ovarian cancer: A 15-year retrospective cohort study.

May 06, 2021

The most common type of ovarian cancer (OC) is epithelial ovarian cancer (EOC) which is the most lethal gynecologic malignancy in adult women.This study aimed to determine the conditional disease-free...

Expanding Lynch Syndrome Screening to Include Ovarian Cancer

Apr 02, 2021

Although the benefits of universal screening for colorectal cancer (CRC) and endometrial cancer (EC) are well known and supported by widespread consensus among major medical and specialty societies, t...

Family history and pathogenic/likely pathogenic germline variants in prostate cancer patients.

Mar 25, 2021

Recent literature highlights the importance of germline genetic testing in prostate cancer (PCa) patients. Surprisingly, a literature review indicates that family history (FH) records are incomplete i...

Chronic Difficulties are Associated with Poorer Psychosocial Functioning in the First Year Post-Diagnosis in Epithelial Ovarian Cancer Patients.

Mar 25, 2021

Ovarian cancer is characterized by poor prognosis, high levels of distress, disturbed sleep, and compromised quality of life (QOL). Although life stressors have been shown to significantly impact phys...

Tumor Forkhead Box Q1 Is Elevated, Correlates with Increased Tumor Size, International Federation of Gynecology and Obstetrics Stage but Worse Overall Survival in Epithelial Ovarian Cancer Patients.

Mar 25, 2021

Forkhead box Q1 (FOXQ1) regulates epithelial ovarian cancer (EOC) cell proliferation, migration, and invasion, while its prognostic effect in EOC patients is unclear. This study aimed to assess FOXQ1...

[Update of the AWMF S2k Guideline "Diagnostics and Assessment of Occupational Asbestos-Related Diseases" - What's New?]

Mar 18, 2021

The S2k guideline "Diagnostics and assessment of occupational asbestos-related diseases" was updated in November 2020. This article summarizes the most important changes. There is a new reference to t...

PD-L1 expression with QR1 and E1L3N antibodies according to histological ovarian cancer subtype: A series of 232 cases.

Mar 18, 2021

Therapeutic strategies for epithelial ovarian cancers are evolving with the advent of immunotherapy, such as PD-L1 inhibitors, with encouraging results. However, little data are available on PDL-1 exp...

Quality of Life and Adverse Events: Prognostic Relationships in Long-Term Ovarian Cancer Survival.

Mar 18, 2021

There is a critical need to identify patient characteristics associated with long-term ovarian cancer survival.Quality of life (QOL), measured by the Functional Assessment of Cancer Therapy-Ovarian-Tr...

Updated Guidance on Fertility Preservation & Post-Treatment Pregnancy in Patients With Post-Pubertal Cancer

Feb 22, 2021

With long-term survivorship increasingly achievable among patients with cancer, many in this population face the outcomes of treatment-related late effects, explain Richard Anderson, MD, PhD, Matteo L...

The RAD51D c.82G>A (p.Val28Met) variant disrupts normal splicing and is associated with hereditary ovarian cancer.

Jan 18, 2021

Mutations in RAD51D are associated with a predisposition to primary ovarian, fallopian tube, and peritoneal carcinoma. Our study aims to characterize a RAD51D missense variant in a hereditary ovarian ...

Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response.

Jan 18, 2021

Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses...

[High-risk screening using magnetic resonance imaging].

Jan 14, 2021

Specialized breast cancer early detection programs with magnetic resonance imaging (MRI) in high-risk patients are by now well established in several countries. In Germany, such a program has been ru...

Deciphering Biophysical Modulation in Ovarian Cancer Cells.

Jan 14, 2021

It has been long known that the oncogenic extracellular environment plays an indispensable role in developing and nurturing cancer cell progression and in resistance to standard treatments. However, b...

Genital powder use and risk of uterine cancer: A pooled analysis of prospective studies.

Jan 14, 2021

When powder is applied to the genital area, it has the potential to reach internal reproductive organs and promote carcinogenesis by irritating and inflaming exposed tissues. While many studies have c...

Transferability of the early-stage ovarian malignancy (EOM) score: an external validation study that includes advanced-stage and metastatic ovarian cancer.

Jan 11, 2021

To validate the diagnostic performance of the Early-stage Ovarian Malignancy (EOM) score in an external dataset that includes advanced-stage and metastatic ovarian cancer.The data from two cross-secti...

Pathogenicity Assessment of Variants for Breast Cancer Susceptibility Genes Based on BRCAness of Tumor Sample.

Jan 11, 2021

Genes involved in the homologous recombination repair pathway-as exemplified by BRCA1, BRCA2, PALB2, ATM and CHEK2-are frequently associated with hereditary breast and ovarian cancer syndrome. Germlin...

Upregulation of long noncoding RNA XIST has anticancer effects on ovarian cancer through sponging miR-106a.

Jan 07, 2021

Ovarian cancer (OC) is a highly malignant tumor. X inactive specific transcript (XIST) was identified as a cancer-related gene, while its therapeutic effect in OC was poorly defined. The present study...

Emerging role of RNF2 in cancer: From bench to bedside.

Jan 07, 2021

RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family, which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 (H2AK119ub). RNF2 g...

Label-Free Electrochemical Immunosensor for Ultrasensitive Detection of Carbohydrate Antigen 125 Based on Antibody-Immobilized Biocompatible MOF-808/CNT.

Jan 07, 2021

In this work, a nanocomposite of Zr-trimesic acid MOF (MOF-808) with carbon nanotube (CNT) was synthesized through an in situ formation of MOF-808 on the activated CNT. The synthesized materials were ...

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