Disulfiram is not effective as an adjunctive therapy to standard chemotherapy for glioblastoma
1. Adding disulfiram and copper to standard alkylating chemotherapy for glioblastoma (GB) was not...
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Oncology
Helicobacter pylori, Homologous Recombination Genes, and Risk of Gastric Cancer
1. The following genes had statistically significant increased odds ratio of gastric cancer;...
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Hyperfractionated radiotherapy reduces complication rates compared to standard fractionation for locally advanced nasopharyngeal carcinoma
1. Fewer patients in the hyperfractionation group reported grade 3 or worse late radiation-induced...
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United States patients receive subcutaneous fluids less frequently than intravenous fluids when compared to Canadian patients
1. Canadian patients receive subcutaneous administration of medications and/or fluids more...
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Alternative Dose Regimens of Exemestane in Postmenopausal Women with Breast Cancer
1. Through the reduction in serum estradiol, there was noninferiority between the 3-times-weekly...
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Adenoma detection rate is inversely associated with post-colonoscopy colorectal cancer risk
1. In this prospective cohort study, the adenoma detection rate (ADR) was inversely associated...
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Nivolumab plus ipilimumab does not improve survival in post-nephrectomy patients with renal cell carcinoma
1. Disease-free survival in the placebo group was 50.7 months and was never reached in the...
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Active monitoring, prostatectomy, and radiotherapy as treatment options for localized prostate cancer result in similar prostate-cancer-mortality
1. Localized prostate cancer mortality remains similar between groups receiving prostatectomy,...
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Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors
1. There is a 71% lower risk of disease progression or death in the nirogacestat group than in the...
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Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer
1. Patients allocated to the sotorasib group reported increased progression-free survival compared...
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Addition of PD-L1 inhibitor may improve outcomes in neoadjuvant therapy for esophageal cancer
1. In this phase II randomized clinical trial, treatment of patients with locally advanced...
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Combination therapy with alisterib and fulvestrant may be clinically advantageous in the treatment of endocrine-resistant advanced breast cancer
1. Compared to alisertib alone, adding alisertib to fulvestrant did not increase objective tumour...
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Maternity genitourinary tract infections associated with increased offspring leukemia risk in Danish cohort
1. In a Danish cohort, maternal genitourinary tract infection during pregnancy was associated with...
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Paid-sick-leave mandates contribute to increased cancer screening in the United States
1. Mandated and available paid-sick-leave resulted in increased colorectal and breast cancer...
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Neoadjuvant–Adjuvant vs. Adjuvant-Only Pembrolizumab in Advanced Melanoma
1. Event-free survival at 2 years was longer in the neoadjuvant-adjuvant group vs the...
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Liver enzymes elevated at 6 months prior to breast cancer liver metastasis detection
1. For patients diagnosed with breast cancer liver metastases (BCLM), liver function tests were...
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Low household income associated with worse outcomes for estrogen receptor-positive breast cancer
1. Low household income is associated with higher 21-gene recurrence scores (score based on gene...
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Risk model-based lung cancer screening is more cost effective than current practice
1. In this comparative modeling study, risk model-based lung cancer screening strategies yielded...
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Spirituality may improve coping in women diagnosed with breast cancer
1. In this scoping review, it was shown that spirituality allowed patients with breast cancer to...
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Medial retropharyngeal nodal region sparing radiotherapy for nasopharyngeal carcinoma
1. In this noninferiority trial, medial retropharyngeal lymph node (MRLN)-sparing radiotherapy was...
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