Ipilimumab addition to nivolumab showed no significant clinical benefit in resected advanced stage melanoma
Ipilimumab addition to nivolumab showed no significant clinical benefit in resected advanced stage...
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Oncology
Letrozole and abemaciclib in estrogen receptor–positive recurrent endometrial cancer
1. Almost half of patients (47%) had either an objective response or had progression free survival...
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Fulvestrant for treatment of estrogen receptor-positive, HER2-negative advanced breast cancer may improve progression free survival using ESR1 mutation as guidance
1. Median progression free survival was longer in the fulvestrant and palbociclib group compared...
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Selpercatinib continues to demonstrate effective response in RET fusion-positive NSCLC
1. Selpercatinib was found to have similar effective objective response rates compared to past...
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Selpercatinib showed promising clinical activity in tumour-agnostic patients with RET fusion-positive cancers other than thyroid and lung cancer
1. Objective response rate was 43.9%. Patients treated with selpercatinib also experienced...
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More permissive parameters for active surveillance eligibility is potentially possible in slow-growing thyroid cancers
1. Patients in the active surveillance group who had forgone surgery had no difference in survival...
Read MoreIncreased pre-chemotherapy inflammatory biomarkers (IL-6 and CRP) correlated to increased risk of frailty post-chemotherapy in older breast cancer patients
1. 25.8% of patients receiving chemotherapy for breast cancer experienced worsening frailty status. 2. Patients with both biomarkers (IL-6 and CRP) elevated before chemotherapy had a significantly higher risk of decline in...
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Adjuvant pembrolizumab increased disease-free survival in completely resected, PD-L1 unselected non-small-cell lung cancer patients
1. Adjuvant pembrolizumab significantly improved disease-free survival in comparison to placebo in...
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Neoadjuvant celmiplimab is associated with pathologic response in cutaneous squamous cell carcinoma
1. After neoadjuvant treatment with celmiplimab, half of the patients were found to have a...
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Impact of ultrasonographic blind spots for early-stage hepatocellular carcinoma during surveillance
1. Hepatocellular carcinoma (HCC) tumours located in ultrasound (US) blind spots were associated...
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Combination avelumab and axitinib treatment of advanced type B3 thymoma and thymic carcinoma is promising as second-line treatment after standard therapy.
1. Patients who had never previously received anti-angiogenesis treatments had longer...
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Treatment with adjuvant mFOLFIRINOX as compared with gemcitabine improves survival outcomes in resected pancreatic cancer
1. Median disease-free survival is longer in patients receiving mFOLFIRINOX as compared to those...
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Routine dexamethasone is not effective compared to placebo to treat dyspnea in patients with advanced cancer
1. There is no significant difference for perceived dyspnea in patients taking dexamethasone as...
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Telaglenastat addition to cabozantinib did not demonstrate benefit in pre-treated advanced renal cell carcinoma
1. Telaglenastat addition to cabozantinib did not show improvements in clinical benefit. 2....
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Incidence of C. difficile infections decreasing in hospitalized children
1. In a very large retrospective cohort of hospitalized pediatric patients, the incidence of C....
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Adjuvant erlotinib increased overall survival when compared to chemotherapy in stage IIIA EGFR-mutant non-small cell lung cancer
1. Erlotinib showed an overall survival benefit and improved 5-year survival rates when compared...
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Sacituzumab govitecan may be an effective treatment for heavily pre-treated HR+/HER2- metastatic breast cancer.
1. Median progression-free survival was longer in the SG group than in the chemotherapy group. 2....
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Many Older Adults With Blood Cancer Taking Too Many Medications
Evaluating specific types of medications an older patient with blood cancer is taking is more...
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Supervised exercise Interventions may significantly benefit childhood cancer survivors
1. Supervised exercise interventions significantly improved muscle strength, daily physical...
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Criteria for low-dose computed tomography lung cancer screening omit a high risk population of smokers
1. A high risk of incident lung cancer exists for smokers that do not meet low-dose computed...
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