Incidence of C. difficile infections decreasing in hospitalized children
1. In a very large retrospective cohort of hospitalized pediatric patients, the incidence of C....
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Oncology
Adjuvant erlotinib increased overall survival when compared to chemotherapy in stage IIIA EGFR-mutant non-small cell lung cancer
1. Erlotinib showed an overall survival benefit and improved 5-year survival rates when compared...
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Sacituzumab govitecan may be an effective treatment for heavily pre-treated HR+/HER2- metastatic breast cancer.
1. Median progression-free survival was longer in the SG group than in the chemotherapy group. 2....
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Many Older Adults With Blood Cancer Taking Too Many Medications
Evaluating specific types of medications an older patient with blood cancer is taking is more...
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Supervised exercise Interventions may significantly benefit childhood cancer survivors
1. Supervised exercise interventions significantly improved muscle strength, daily physical...
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Criteria for low-dose computed tomography lung cancer screening omit a high risk population of smokers
1. A high risk of incident lung cancer exists for smokers that do not meet low-dose computed...
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Same appointment mammogram results may result in less stress for patients being screened for breast cancer
1. Same appointment mammogram results had a positive impact on breast cancer screening experience...
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Pembrolizumab plus chemotherapy improved survival in a subgroup of triple-negative metastatic breast cancer
1. Pembrolizumab plus chemotherapy for triple-negative breast cancer significantly increased PFS...
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Topical hypericin photodynamic therapy is effective and safe in early-stage T cell lymphoma
1. Hypericin photodynamic therapy was found to be more efficacious in treating early-stage T cell...
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Survival is similar for patients with autoimmune disease treated with immune checkpoint inhibitors compared to patients with no autoimmune disease
1. There was no significant difference in efficacy of ICIs in cancer patients with or without AID....
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Breast, colorectal, and cervical cancer screening was reduced during the COVID-19 pandemic as compared to pre-COVID time periods.
1. All cancer types had the greatest decrease in screening during the early part of the pandemic....
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LCAR-B38M CAR-T cell therapy promising at 4-year follow-up for treatment of refractory multiple myeloma
1. At a 4-year follow-up for relapsed or refractory multiple myeloma (RRMM) patients treated with...
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IsoPSA Shows Notable Diagnostic Accuracy in Detecting Prostate Cancer
The IsoPSA biomarker displays superior diagnostic accuracy in the early detection of prostate...
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FOLFOX combined with nivolumab and trastuzumab in ERBB2-positive esophagogastric adenocarcinoma is an emerging therapy option
1. Overall survival rate at 12 months for the FOLFOX arm and ipilimumab arm was 70% and 57%,...
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Adding atezolizumab to standard of care treatment for human epidermal growth factor receptor 2 (HER2) positive early breast cancer does not improve pathologic response outcomes
1. The pathologic response rate was similar in the atezolizumab treatment group as compared to...
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Lisocabtagene maraleucel improves survival for relapsed or refractory large B-cell lymphoma
1. Median event-free survival in the liso-cel group was significantly greater than in the...
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High tumour mutation burden in NSCLC associated with improved clinical outcomes of PD-L1 blockade across PD-L1 expression subgroups
1. High tumour mutation burden levels were associated with improvements in objective response...
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Treatment of anal high-grade squamous intraepithelial lesions can reduce rates of progression to invasive anal cancer.
1. The rate of progression was 57% lower in the group receiving anal HSIL treatment as compared to...
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Human papillomavirus (HPV) vaccination rates have increased in recent years
1. Between 2015 and 2020, human papillomavirus vaccination (HPV) rates in the United States...
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Circulating Tumour DNA Analysis reduced adjuvant chemotherapy use while not compromising recurrence-free survival in stage II colon cancer
1. The circulating tumour DNA-guided approach was non-inferior to the standard clinicopathological...
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