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Ophthalmology General

Missense variants in CTNNB1 can be associated with vitreoretinopathy-Seven new cases of CTNNB1-associated neurodevelopmental disorder including a previously unreported retinal phenotype.

Dec 24, 2020

CTNNB1 (MIM 116806) encodes beta-catenin, an adherens junction protein that supports the integrity between layers of epithelial tissue and mediates intercellular signaling. Recently, various heterozyg...

New Freeware for Image Analysis of Lissamine Green Conjunctival Staining.

Dec 24, 2020

Lissamine green (LG) is often used in addition to fluorescein to assess the severity of conjunctival damage in dry eye syndrome, which is graded manually. Our purpose was to describe an algorithm desi...

Influence of Different Antidepressants on Ocular Surface in Patients With Major Depressive Disorder.

Dec 24, 2020

Several studies have previously reported the association between dry eye and depression along with the treatment of depression. The aim of this study was to investigate the effects of different antide...

Treatment of experimental choroidal neovascularization via RUNX1 inhibition.

Dec 24, 2020

Choroidal neovascularization (CNV) is a prevalent cause of vision loss in patients with age-related macular degeneration. Runt-related transcription factor 1 (RUNX1) has been identified as an importan...

Phytotherapeutic and Natural Compound Applications for Age-Related, Inflammatory and Serious Eye Ailments.

Dec 24, 2020

Tissue cells of the eye are sensitive to oxidative stress leading to oxidative damage and inflammation, which have crucial roles in the pathogenesis of most of the eye diseases. Moreover, factors such...

Anemia and Diabetic Kidney Disease Had Joint Effect on Diabetic Retinopathy Among Patients With Type 2 Diabetes.

Dec 24, 2020

Whether the association between diabetic kidney disease (DKD) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) is leveraged by anemia remains unclear. This study is to ev...

Effect of Rho Kinase Inhibitor Ripasudil (K-115) on Isolated Porcine Retinal Arterioles.

Dec 24, 2020

To investigate the vasorelaxation effect of ripasudil (K-115), a novel Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor, on isolated retinal arterioles. We determined whether the...

Progression of Macular Vessel Density in Primary Open-Angle Glaucoma: A Longitudinal Study.

Dec 24, 2020

To evaluate the rate of progression of macular vessel density (mVD) in primary open-angle glaucoma (POAG) and explore the relationship between the progression of mVD and macular ganglion cell-inner pl...

Clinical and Economic Burden of Glaucoma by Disease Severity: A US Claims-Based Analysis.

Dec 24, 2020

To provide updated estimates of the clinical and economic burden in patients with ocular hypertension (OHT) or open-angle glaucoma (OAG) by disease severity in United States patients and estimate incr...

Does daily dietary intake affect diabetic retinopathy progression?

Dec 22, 2020

Researchers did this study to evaluate dietary consumption associations with the 10-year incidence of DR progression in working-aged Australians with diabetes. Researchers obtained longitudinal data ...

Association of renal function with retinal vessel density

Dec 22, 2020

Researchers did this study to investigate the relationship between retinal vessel density and renal function in patients with DM using non-invasive OCTA. This prospective cross-sectional study recrui...

The disparity of microaneurysm count between ultrawide field color imaging and ultrawide field fluorescein angiography

Dec 22, 2020

Researchers did this study to compare MA counts using UWF-CI and UWF-FA. The present study is a retrospective study, including patients with type 1 or 2 diabetes mellitus receiving UWF-FA and UWF-CI ...

Real-world management of treatment-naïve diabetic macular edema

Dec 22, 2020

Researchers did this study to investigate the yearly change of real-world outcomes for BCVA after a 2-year clinical intervention for treatment-naïve DMO. Retrospective analysis of aggregated, longit...

Rimegepant Bests Placebo for Preventing Migraine

Dec 22, 2020

MONDAY, Dec. 21, 2020 (HealthDay News) -- Taken every other day, rimegepant demonstrates efficacy for the preventive treatment of migraine, according to a study published online Dec. 15 in The Lancet....

Long-Term Care Workers Often Hold Multiple Jobs

Dec 22, 2020

MONDAY, Dec. 21, 2020 (HealthDay News) -- Long-term care workers in nursing homes commonly hold multiple jobs, which may be contributing to the spread of COVID-19 in nursing homes, according to a stud...

Prevalence of myopic macular degeneration worldwide

Dec 22, 2020

Researchers did this study to investigate the prevalence of MMD in the global population. Researchers selected only those published literature of population-based studies on MMD prevalence with preci...

Optical coherence tomography-based consensus definition for lamellar macular hole

Dec 22, 2020

A consensus on a definition of LMH and similar conditions is needed. The panel reviewed relevant peer-reviewed literature to reach an accord on LMH definition and differentiate LMH from similar situat...

Prediction of OCT images of short-term response to anti-VEGF treatment

Dec 22, 2020

Researchers did this study to generate and evaluate individualized post-therapeutic optical coherence tomography (OCT) images that could predict the short-term response of antivascular endothelial gro...

Improved localization and discrimination of heat-emitting household objects

Dec 22, 2020

Researchers did this study to demonstrate the potential clinically meaningful benefits of a thermal camera integrated with the Argus II, an artificial vision therapy system. Seven blind patients impl...

Asymmetry analysis of macular optical coherence tomography angiography

Dec 22, 2020

Quantitative analysis of OCT-A images requires a reproducible approach that accounts for sectoral loss. This study’s objective was to determine whether an index that accounts for both global (perfus...

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