Oct 02, 2023

Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic DNA, recognizes cytoplasmic nucleic acids to activate the innate immune responses via generation of the second messenger cGAMP and subsequ...

Oct 02, 2023

Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The timely regulation of blo...

Oct 02, 2023

Diseases leading to retinal cell loss can cause severe visual impairment and blindness. The lack of effective therapies to address retinal cell loss and the absence of intrinsic regeneration in the hu...

Oct 02, 2023

Private equity (PE) firms are increasingly acquiring ophthalmology practices; little is known of their influence on care utilization and spending. We studied changes in utilization and Medicare spendi...

Sep 25, 2023

This study aims to identify potential myopia biomarkers using machine learning algorithms, enhancing myopia diagnosis and prognosis prediction.GSE112155 and GSE15163 datasets from the GEO database wer...

Sep 25, 2023

The muscarinic cholinergic antagonist atropine is the most widely used pharmacological treatment for the visual disorder myopia (short-sightedness), the leading cause of low-vision worldwide. This stu...

Sep 25, 2023

The innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental stresses. The epithelium is central to the innate immune response, but wh...

Sep 25, 2023

The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is an important part of the natural immune system that plays an important role in many diseases. Estrogen is ...

Sep 25, 2023

This study aimed to investigate alterations of outer retinal reflectivity on spectral-domain optical coherence tomography (OCT) in diabetic patients without clinically detectable retinopathy (NDR).In ...

Sep 25, 2023

Mechanisms responsible for the pathogenesis of diabetic retinal disease remain incompletely understood, but likely involve multiple cellular targets, including photoreceptors. Evidence suggests that d...

Sep 25, 2023

The glaucomas are a group of conditions leading to irreversible sight loss and characterised by progressive loss of retinal ganglion cells. Although not always elevated, intraocular pressure is the on...

Sep 25, 2023

In the present work, novel interpenetrated networks (IPNs) of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide) (SBMA) and poly(vinyl alcohol) (PVA) were prepared for the ocular co...

Sep 25, 2023

To assess the demographic characteristics and geographic distribution of neuro-ophthalmologists practicing in the US.A cross-sectional study.Neuro-ophthalmologists across the US.In this cross-sectiona...

Sep 25, 2023

To analyze ophthalmology workforce supply and demand projections from 2020 to 2035 DESIGN: Observational cohort studying using data from the National Center for Health Workforce Analysis (NCHWA) METHO...

Sep 18, 2023

Macular edema (ME) in the setting of retinal vein occlusions (RVO) is a common cause of vision loss worldwide. Anti-vascular endothelial growth factor (anti-VEGF) injections are the gold standard for ...

Sep 18, 2023

The prevalence of myopia is increasing across the world. Controlling myopia progression would be beneficial to reduce adverse outcomes such as retinal detachment and myopic maculopathy which are assoc...

Sep 18, 2023

The present study analyzed the reciprocal relationships between four common pediatric ophthalmic diseases (i.e., hyperopia, myopia, astigmatism, and strabismus) and ADHD in children.This study enrolle...

Sep 18, 2023

In this cross-sectional survey, we assessed the prevalence of dry eye disease (DED) in a representative German population sample. In addition, we examined the associations between DED, health-related ...

Sep 18, 2023

This study aimed to determine the threshold for defining abnormal retinal sensitivity (RS) that correlates with structural changes in diabetic macular ischemia (DMI) patients with stable treated proli...

Sep 18, 2023

In this study, rat retinal Müller cells (RMCs) were cultured in vitro to investigate the protective mechanism of evolocumab on rat RMCs in diabetes mellitus (DM) and the expression of relevant inflam...