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Ophthalmology General

Keratoconus staging by decades

Nov 09, 2020

This study aims to analyse the keratoconus (KC) stage distribution at different ages within the Homburg Keratoconus Center (HKC). 1000 patients were selected out of which 728 of the patients were mal...

Automated detection of early-stage ROP using a deep convolutional neural network

Nov 09, 2020

The study was done to automatically detect and classify the early stages of retinopathy of prematurity (ROP) using a deep convolutional neural network (CNN). This retrospective cross-sectional study ...

Ophthalmic adverse effects of immune checkpoint inhibitors: the Mayo Clinic experience

Nov 09, 2020

This study was done to investigate immune-related ophthalmic side effects of systemic checkpoint inhibitors and compare side effect frequency and requirement for cessation of immunotherapy by checkpoi...

Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

Nov 09, 2020

The study was done to standardise the nomenclature for reporting OCT-A findings in the field of uveitis. Members of the International Uveitis Study Group, of the American Uveitis Society and of the S...

The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship.

Nov 09, 2020

To elucidate how variants in genetic risk loci previously implicated in Alzheimer's Disease (AD) and/or frontotemporal dementia (FTD) contribute to expression of disease phenotypes, a phenome-wide ass...

PPARγ modulates refractive development and form deprivation myopia in Guinea pigs.

Nov 09, 2020

Form deprivation myopia (FDM) is characterized by loss of choroidal thickness (ChT), reduced choroidal blood perfusion (ChBP), and consequently scleral hypoxia. In some tissues, changes in levels of p...

Temporal color contrast guides emmetropization in chick.

Nov 09, 2020

As a result of longitudinal chromatic aberration (LCA), longer wavelengths are blurred when shorter wavelengths are in focus, and vice versa. As a result, LCA affects the color and temporal aspects of...

The HYLAN M Study: Efficacy of 0.15% High Molecular Weight Hyaluronan Fluid in the Treatment of Severe Dry Eye Disease in a Multicenter Randomized Trial.

Nov 09, 2020

The aim of the HYLAN M study was to investigate if symptoms and/or signs of patients suffering from severe dry eye disease (DED) can be improved by substituting individually optimized artificial tear ...

Easy and effective test to evaluate tear-film stability for self-diagnosis of dry eye syndrome: blinking tolerance time (BTT).

Nov 09, 2020

The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic ...

Genetically Encoded Calcium Indicators for In Situ Functional Studies of Corneal Nerves.

Nov 09, 2020

Millions of people suffer from diseases that involve corneal nerve dysfunction, caused by various conditions, including dry eye syndrome, neurotrophic keratopathy, diabetes, herpes simplex, glaucoma, ...

Elucidation of Pathophysiology and Novel Treatment for Diabetic Macular Edema Derived from the Concept of Neurovascular Unit.

Nov 09, 2020

The retina transmits light signals to the brain via a complex structure composed of photoreceptor cells, neurons including ganglion cells, glial cells such as astrocytes and Mueller cells, as well as ...

miR-200-3p suppresses cell proliferation and reduces apoptosis in diabetic retinopathy via blocking the TGF-β2/Smad pathway.

Nov 09, 2020

Increasing evidence has shown that microRNAs (miRNAs) play an important role in the pathogenesis of diabetic retinopathy (DR). However, the role and mechanism of miRNA in regulating high glucose (HG)-...

Normal vitreous promotes angiogenesis via activation of Axl.

Nov 09, 2020

Vitreous has been reported to prevent tumor angiogenesis, but our previous findings indicate that vitreous activate the signaling pathway of phosphoinositide 3-kinase (PI3K)/Akt, which plays a critica...

G-protein-coupled estrogen receptor protects retinal ganglion cells via inhibiting endoplasmic reticulum stress under hyperoxia.

Nov 09, 2020

Abnormal development of immature retinal vascular structure in preterm infants under the condition of hyperoxia is the primary cause of retinopathy of prematurity (ROP), which has become the leading c...

Brinzolamide loaded core-shell nanoparticles for enhanced coronial penetration in the treatment of glaucoma.

Nov 09, 2020

A neurodegenerative disorder, glaucoma is a leading cause of blindness in the world. The conventional treatment strategies do not allow the significant penetration of the drug in the cornea. Therefore...

Preliminary evaluations of 3-dimensional human skin models for their ability to facilitate in vitro the long-term development of the debilitating obligatory human parasite Onchocerca volvulus.

Nov 09, 2020

Onchocerciasis also known as river blindness is a neglected tropical disease and the world's second-leading infectious cause of blindness in humans; it is caused by Onchocerca volvulus. Current treatm...

Efficiency of Operating Room Processes for Elective Cataract Surgeries Done by Residents in a National University Hospital.

Nov 09, 2020

Operating room processes must be efficient to boost profitability and minimize cost while retaining surgical care quality. This study aims to assess operating room efficiency for resident-performed el...

Influence of Perfluorocarbon Liquids on Peripapillary Retinal Nerve Fiber-Layer Thickness Following Pars Plana Vitrectomy with Silicone Oil-Based Endotamponade.

Nov 09, 2020

Inner retina-layer modifications after pars plana vitrectomy (PPV) can be objectively assessed through spectral domain optical coherence tomography (SD-OCT).This study explored prospectively changes i...

What can anisometropia tell us about eye growth?

Nov 07, 2020

The study explored the interocular differences in biometry to determine the potential role of other factors in refractive development. In 362 subjects Childhood Errors of Refraction study were studie...

Can we eradicate trachoma? A survey of stakeholders

Nov 06, 2020

Although tremendous progress towards the 2020 goal of global elimination of trachoma as a public health problem has been made, it will not be achieved. Future targets are now being considered. One opt...

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