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Ophthalmology General

Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy.

Aug 06, 2020

Loss of the blood-retinal barrier (BRB) integrity and subsequent damage to the neurovascular unit in the retina are the underlying reasons for diabetic retinopathy (DR). Damage to BRB eventually leads...

Vision impairment and depression among older adults in low- and middle-income countries.

Aug 06, 2020

To investigate the association between visual impairment (VI) and depression in low- and middle-income countries (LMICs) and the mediating role of disability and social participation.The World Health ...

Prevalence of Charles Bonnet syndrome in patients with glaucoma: a systematic review with meta-analyses.

Aug 06, 2020

Glaucoma is a widespread sight-threatening condition often only recognized when very pronounced. It is initially characterized by peripheral visual field losses, while advanced stages also affect the ...

Time to Presentation after Symptom Onset in Endophthalmitis: Clinical Features and Visual Outcomes.

Aug 06, 2020

To investigate the impact of time from symptom onset to presentation on the clinical course and outcomes of eyes with endophthalmitis.Retrospective longitudinal cohort study.One hundred and thirty-thr...

Assessment of Systems and Services for Management of Diabetes and Diabetic Retinopathy in Cameroon.

Aug 03, 2020

To evaluate systems and services for management of diabetes and diabetic retinopathy.The National Program for Blindness Control conducted a nationwide descriptive study from 1 February to 31 October 2...

Novel mutation identified in Leber congenital amaurosis - a case report.

Aug 03, 2020

Leber congenital amaurosis (LCA) is the earliest onset and the most severe form of all inherited retinal degenerative disorders, characterized by blindness, or severe visual impairment from birth, and...

High density lipoproteins are a potential therapeutic target for age-related macular degeneration.

Aug 03, 2020

Strong evidence suggests that dysregulated lipid metabolism involving dysfunction of the retinal pigmented epithelium (RPE) underlies the pathogenesis of age-related macular degeneration (AMD), the le...

Gender Specific Differences in Signs and Symptoms of Dry Eye Disease.

Aug 03, 2020

Dry Eye Disease (DED) is a multifactorial disease of the ocular surface characterized by loss of homeostasis of the tear film. Epidemiological studies suggest it occurs more frequently in women than m...

NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye.

Aug 03, 2020

Dry eye disease (DED) is a common and multifactor-induced autoimmune ocular surface disease. Environmental factors, such as desiccating stress (DS) and hyperosmolarity, affect the corneal epithelium t...

Efficacy and retention of silicone punctal plugs for treatment of dry eye in patients with and without ocular graft-versus-host-disease.

Aug 03, 2020

To examine the retention rates and efficacy of silicone punctal plugs for the treatment of dry eye disease (DED) in patients with ocular graft-versus-host-disease (oGVHD) in comparison to dry eye dise...

Aspirin in a diabetic retinopathy setting: Insights from NO BLIND study.

Aug 03, 2020

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes. Diabetic macroangiopathies, particularly cardiovascular (CV) diseases, seem closely related to diabetes microvascul...

Circulating Metabolites and Lipids are Associated to Diabetic Retinopathy in Individuals With Type 1 Diabetes.

Aug 03, 2020

Omics based methods may provide new markers associated to diabetic retinopathy (DR). We investigated a wide omics panel of metabolites and lipids related to DR in type 1 diabetes. Metabolomic analyses...

Long-term outcomes of therapeutic penetrating keratoplasty for microbial keratitis in a tertiary care center in Turkey.

Aug 03, 2020

To present the long-term results of therapeutic keratoplasty for microbial keratitis in moderate to advanced phases.The medical records of 44 patients who underwent therapeutic keratoplasty for microb...

The photopic negative response (PhNR): measurement approaches and utility in glaucoma.

Aug 03, 2020

Visual electrophysiological testing continues to generate interest among glaucoma experts because of its potential help in clarifying disease pathophysiology and promoting early detection of glaucomat...

The Effectiveness of Intracameral Moxifloxacin Endophthalmitis Prophylaxis for Trabeculectomy.

Aug 03, 2020

The effect of intracameral (IC) moxifloxacin prophylaxis in preventing acute post-operative endophthalmitis, a rare but potentially visually devastating surgical complication, remains unstudied for gl...

Recent theranostic paradigms for the management of Age-related macular degeneration.

Jul 30, 2020

Degenerative diseases of eye like Age-related macular degeneration (AMD), that affects the central portion of the retina (macula), is one of the leading causes of blindness worldwide especially in the...

[New evidence on the protector effect of weight gain in retinopathy of prematurity].

Jul 30, 2020

Retinopathy of prematurity (ROP) is characterised by insufficient vascular development in the retina, and requires early treatment to avoid visual disability in severe cases. ROP is currently the seco...

Does Blindness Boost Working Memory? A Natural Experiment and Cross-Cultural Study.

Jul 30, 2020

Intelligence requires sufficient working-memory capacity. Traditionally, working memory was seen as a process and as a prerequisite for fluid intelligence. Working memory was assumed to be determined ...

Meibomian glands structure in daily disposable soft contact lens wearers: a one-year follow-up study.

Jul 30, 2020

To assess the impact of daily disposable soft contact lenses on meibomian gland morphology over a period of 12 months.Forty-one subjects (33 experienced and 8 neophytes) were fitted with either silic...

Assessing the ocular surface microbiome in severe ocular surface diseases.

Jul 30, 2020

There is growing evidence for a critical role of the microbiome in ocular health and disease. We performed a prospective, observational study to characterize the ocular surface microbiome (OSM) in fou...

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