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Ophthalmology General

Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model.

Jul 23, 2020

Age-related macular degeneration (AMD) is a chronic, multifactorial disorder and a leading cause of blindness in the elderly. Characterized by progressive photoreceptor degeneration in the central ret...

Resilience, anxiety and depression, coping style, social support and their correlation in parents of premature infants undergoing outpatient fundus examination for retinopathy of prematurity.

Jul 23, 2020

Retinopathy of prematurity (ROP) has become the main cause of blindness in children. To study resilience, anxiety and depression, coping style and social support and their correlation in parents of pr...

Retinal Glial and Choroidal Vascular Pathology in Donors Clinically Diagnosed With Stargardt Disease.

Jul 23, 2020

The present study investigated retinal glia and choroidal vessels in flatmounts and sections from individuals with clinically diagnosed Stargardt disease (STGD).Eyes from three donors clinically diagn...

Effect of natural extract eye drops in dry eye disease rats.

Jul 23, 2020

To investigate the therapeutic effect of natural extract eye drops containing bee venom, musk, and deer antlers in dry eye disease (DED) animal models.Scopolamine-injected DED rats and lacrimal gland-...

Metabolomic analysis in ophthalmology.

Jul 23, 2020

Modern science takes into account phenotype complexity and establishes approaches to track changes on every possible level. Many "omics" studies have been developed over the last decade. Metabolomic a...

Ocular Demodex: a systematic review of the clinical literature.

Jul 23, 2020

There is increasing clinical and research interest in the potential contribution of Demodex to ocular surface disease. The aim of this systematic review was to summarise and synthesise current clinica...

Zinc oxide nanoparticles from Cyperus rotundus attenuates diabetic retinopathy by inhibiting NLRP3 inflammasome activation in STZ-induced diabetic rats.

Jul 23, 2020

Diabetic retinopathy (DRP) is a retinal disease caused by diabetes mellitus, which is categorized by microvascular lesions present in the retina such as vascular leakage, vascular proliferation, and r...

Unique molecular signatures of microRNAs in ocular fluids and plasma in diabetic retinopathy.

Jul 23, 2020

The main objective of this pilot study was to identify circulatory microRNAs in aqueous or plasma that were reflecting changes in vitreous of diabetic retinopathy patients. Aqueous, vitreous and plasm...

Retinal proteomics of experimental glaucoma model reveal intraocular pressure-induced mediators of neurodegenerative changes.

Jul 23, 2020

Current evidence suggests that exposure to chronically induced intraocular pressure (IOP) leads to neurodegenerative changes in the inner retina. This study aimed to determine retinal proteomic altera...

Comparison of peripapillary Capillary Density in Glaucoma Patients of African and European descent.

Jul 23, 2020

To evaluate racial differences in optic nerve head peripapillary capillary density measured by optical coherence tomography angiography (OCTA) in patients with open-angle glaucoma.Observational, cross...

Glaucoma after ocular surgery or trauma: the role of infiltrating monocytes and their response to cytokine inhibitors.

Jul 23, 2020

Glaucoma is a frequent and devastating long-term complication following ocular trauma, including corneal surgery, open globe injury, chemical burn, infection, etc. Post-event inflammation and neurogli...

Filtering-associated Endophthalmitis Following Trabeculectomy or Tube-shunt Implant.

Jul 23, 2020

To determine the rate, clinical features, and outcomes of filtering-associated endophthalmitis in eyes that underwent trabeculectomy or tube-shunt implantation.Retrospective database study with select...

Return to the Operating Room after Vitrectomy for Vitreous Opacities: IRIS® Registry Analysis.

Jul 23, 2020

To investigate the rate of return to the operating room after vitrectomy surgery for vitreous opacities DESIGN: A retrospective registry cohort PARTICIPANTS: Individuals receiving care in ophthalmolog...

Stakeholder-Engaged Derivation of Patient-Informed Value Elements.

Jul 20, 2020

Our objective was to identify patient-informed value elements that can be used to make value assessment more patient centered.Mixed methods were used iteratively to collect and integrate qualitative a...

Validation of WINROP (online prediction model) to identify severe retinopathy of prematurity (ROP) in an Australian preterm population: a retrospective study.

Jul 20, 2020

Retinopathy of prematurity (ROP) is the most common disease leading to blindness in extreme preterm infants. Current screening guidelines recommend frequent eye examinations. There is a dearth of trai...

Periorbital botulinum toxin A improves photophobia and sensations of dryness in patients without migraine: Case series of four patients.

Jul 20, 2020

Individuals receiving botulinum toxin A (BoNT-A) injections in the head and neck for migraine treatment have reported decreases in photophobia and sensations of dryness, independent of ocular surface ...

Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease.

Jul 20, 2020

The purpose of this study was to determine the pathogenic changes that occur in myoepithelial cells (MECs) from lacrimal glands of a mouse model of Sjogren's syndrome. MECs were cultured from lacrimal...

Prospects of Temperature Management in Vitreoretinal Surgery.

Jul 20, 2020

Currently, there are no clear recommendations about the safety of certain temperature conditions for intraocular structures during vitreoretinal surgery; instructions on the safe rate of rewarming of ...

Associations between alcohol intake and diabetic retinopathy risk: a systematic review and meta-analysis.

Jul 20, 2020

Some previous studies have reported inconsistent results on the association between alcohol intake and diabetic retinopathy (DR) risk. This study aimed to evaluate the potential effects of alcohol int...

Effects of Induced Astigmatism on Spectral Domain-OCT Angiography Quantitative Metrics.

Jul 20, 2020

To analyze the effect of induced astigmatism on en-face spectral-domain optical coherence tomography angiography (SD-OCTA) quantitative metrics.Prospective Cross-Over Study METHODS: Normal eyes withou...

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