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Ophthalmology General

Validation of WINROP (online prediction model) to identify severe retinopathy of prematurity (ROP) in an Australian preterm population: a retrospective study.

Jul 20, 2020

Retinopathy of prematurity (ROP) is the most common disease leading to blindness in extreme preterm infants. Current screening guidelines recommend frequent eye examinations. There is a dearth of trai...

Periorbital botulinum toxin A improves photophobia and sensations of dryness in patients without migraine: Case series of four patients.

Jul 20, 2020

Individuals receiving botulinum toxin A (BoNT-A) injections in the head and neck for migraine treatment have reported decreases in photophobia and sensations of dryness, independent of ocular surface ...

Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease.

Jul 20, 2020

The purpose of this study was to determine the pathogenic changes that occur in myoepithelial cells (MECs) from lacrimal glands of a mouse model of Sjogren's syndrome. MECs were cultured from lacrimal...

Prospects of Temperature Management in Vitreoretinal Surgery.

Jul 20, 2020

Currently, there are no clear recommendations about the safety of certain temperature conditions for intraocular structures during vitreoretinal surgery; instructions on the safe rate of rewarming of ...

Associations between alcohol intake and diabetic retinopathy risk: a systematic review and meta-analysis.

Jul 20, 2020

Some previous studies have reported inconsistent results on the association between alcohol intake and diabetic retinopathy (DR) risk. This study aimed to evaluate the potential effects of alcohol int...

Effects of Induced Astigmatism on Spectral Domain-OCT Angiography Quantitative Metrics.

Jul 20, 2020

To analyze the effect of induced astigmatism on en-face spectral-domain optical coherence tomography angiography (SD-OCTA) quantitative metrics.Prospective Cross-Over Study METHODS: Normal eyes withou...

Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability.

Jul 20, 2020

To determine normative values, intra- and inter-session variability for a range of parameters derived from the photopic negative response (PhNR) using a handheld mini-Ganzfeld stimulator in healthy no...

Anti-vascular endothelial growth factor in neovascular age-related macular degeneration - a systematic review of the impact of anti-VEGF on patient outcomes and healthcare systems.

Jul 20, 2020

Systematically review the evidence describing the impact of anti-vascular endothelial growth factor (anti-VEGF) therapy on neovascular age-related macular degeneration (nAMD) patient outcomes and heal...

Meibomian gland dysfunction is the primary determinant of dry eye symptoms: Analysis of 2346 patients.

Jul 20, 2020

To determine relative contributions of various ocular surface clinical signs and predisposing factors to the magnitude of dry eye symptoms.Clinical audit data were prospectively collected for newly re...

Central retinal artery occlusion as a post-transfusion complication of red blood cells.

Jul 16, 2020

A 32-year-old woman presented with a history of uterine myomatosis and repeated bleeding for 6 months. This produced a haemoglobin concentration of 6.5 g/dL, with a requirement for a red blood cell t...

MicroRNA-148a-3p alleviates high glucose-induced diabetic retinopathy by targeting TGFB2 and FGF2.

Jul 16, 2020

Diabetic retinopathy (DR), a common complication of type 1 or type 2 diabetes mellitus, has become the leading cause of blindness among adults in working age. The dysregulation of microRNA has been re...

Cataract Surgery Destabilises Temporary the Tear Film of the Ocular Surface.

Jul 16, 2020

Symptoms due to dry eye in the form of keratoconjunctivitis sicca (KCS) are often seen after cataract surgery. We investigated the influence of cataract surgery on tear film stability on the ocular su...

Rete ridges in eyelid margin and inflammatory cytokines in meibomian gland dysfunction associated with dry eye symptom.

Jul 16, 2020

To evaluate the morphology and function of rete ridges in eyelid margin and inflammatory cytokines in meibomian gland dysfunction (MGD) associated with dry eye symptom.A total of 63 subjects with OSDI...

Visualization of micro-neuromas by using in vivo confocal microscopy: An objective biomarker for the diagnosis of neuropathic corneal pain?

Jul 16, 2020

The diagnosis of neuropathic corneal pain (NCP) is challenging, as it is often difficult to differentiate from conventional dry eye disease (DED). In addition to eye pain, NCP can present with similar...

Effects of rhaponticin on retinal oxidative stress and inflammation in diabetes through NRF2/HO-1/NF-κB signalling.

Jul 16, 2020

Oxidative stress and inflammation have long been considered to be responsible for the development and progression of diabetic retinopathy. On the other hand, rhaponticin (RN) has received scientific a...

Choroidal differences between spectral and swept-source domain technologies.

Jul 16, 2020

To assess differences in healthy eyes in volume (CV) and choroidal thicknesses (CT) across all macular Early Treatment Diabetic Retinopathy Study (ETDRS) areas measured by swept source (SS)-OCT and sp...

Altered Red blood cell deformability - A novel hypothesis for retinal microangiopathy in diabetic retinopathy.

Jul 16, 2020

Impaired red blood cell (RBC) deformability impedes tissue perfusion. This study aims to investigate RBC biomechanics in type 2 diabetes mellitus (DM) patients with different grades of diabetic retino...

Understanding metabolism related differences in ocular efficacy of MGV354.

Jul 16, 2020

was being developed as a novel ocular therapy for lowering of intraocular pressure, a key modifiable risk factor for glaucoma. is an activator of soluble guanylate cyclase, an enzyme known to be inv...

VARIABILITY OF VISION HEALTH RESPONSES ACROSS MULTIPLE NATIONAL SURVEY IN THE UNITED STATES.

Jul 16, 2020

Lay the groundwork for future survey validation and harmonization efforts by comparing prevalence rates of self-reported visual impairment (VI) and blindness measured across federally-funded national ...

Short-Term and Long-Term Variability of Intraocular Pressure Measured with an Intraocular Telemetry Sensor in Patients with Glaucoma.

Jul 16, 2020

To evaluate the short- and long-term variability of intraocular pressure (IOP) in eyes with primary open-angle glaucoma (POAG).Twenty-two patients who had previously been implanted with a sulcus based...

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