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Ophthalmology General

Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.

Jul 09, 2020

Cigarette smoking, a powerful mixture of chemical oxidants, is the strongest environmental risk factor for developing age-related macular degeneration (AMD), the most common cause of blindness among t...

Blau syndrome: NOD2-related systemic autoinflammatory granulomatosis.

Jul 06, 2020

Blau syndrome, or early-onset sarcoidosis, is hereditary juvenile-onset systemic granulomatosis. Clinical symptoms appear before the age of 4 years and mainly affect the skin, joints, and eyes. The sy...

Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution.

Jul 06, 2020

To evaluate the effects of a hydroxypropyl guar (HPG) and hyaluronic acid (HA) ophthalmic solution in terms of post-cataract surgery dry-eye disease (DED) prevention.In this retrospective study, the d...

Evaluation of objective visual quality in dry eye disease and corneal nerve changes.

Jul 06, 2020

To explore objective visual quality in dry eye diseases (DED) and the correlation between corneal nerves and objective visual quality.Ninety-eight eyes of 49 patients with DED were included. Each pati...

Optical quality in patients with dry eye before and after treatment.

Jul 06, 2020

Dry eye disease could result in vision-related subjective symptoms even in patients with good best-corrected visual acuity. The standard deviation of corneal power and the surface asymmetry index coul...

Hybrid machine learning architecture for automated detection and grading of retinal images for diabetic retinopathy.

Jul 06, 2020

: Diabetic retinopathy is the leading cause of blindness, affecting over 93 million people. An automated clinical retinal screening process would be highly beneficial and provide a valuable second op...

TIR generated by Continuous Glucose Monitoring is associated with peripheral nerve function in type 2 diabetes.

Jul 06, 2020

Continuous glucose monitoring (CGM)-derived time-in-range (TIR) of 3.9-10 mmol/L is associated with diabetic retinopathy in type 2 diabetes (T2DM), but its relationship to peripheral nerve function ha...

PPARα activation directly upregulates thrombomodulin in the diabetic retina.

Jul 06, 2020

Two large clinical studies showed that fenofibrate, a commonly used peroxisome proliferator-activated receptor α (PPARα) agonist, has protective effects against diabetic retinopathy. However, the un...

Metabolic Syndrome is Associated with Ocular Hypertension and Glaucoma.

Jul 06, 2020

Glaucoma remains the world's leading cause of irreversible blindness and though intraocular pressure (IOP) is the most prevalent risk factor and only reliable therapeutic target, a number of systemic ...

[Clinical and genetic analysis of a patient with rare nephronophthisis].

Jul 06, 2020

To explore the genetic basis for a child with clinically suspected nephronophthisis (NPHP).Peripheral blood samples of the patient and her parents were collected subjected to high-throughput sequencin...

Long-term outcomes of Descemet membrane endothelial keratoplasty in eyes with prior glaucoma surgery.

Jul 06, 2020

To evaluate the long-term outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with prior trabeculectomy and/or drainage device.Retrospective, noncomparative case series.Medical recor...

Incidence, characteristics, outcomes and confidence in managing posterior capsular rupture during cataract surgery in the UK: an ophthalmology trainees' perspective.

Jul 06, 2020

To examine the incidence, characteristics and outcomes of posterior capsular rupture (PCR) cases amongst the ophthalmology trainees and to evaluate the trainees' confidence in managing PCR.A two-stage...

Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy.

Jul 02, 2020

Inherited retinal dystrophies and late-stage age-related macular degeneration, for which treatments remain limited, are among the most prevalent causes of legal blindness. Retinal prostheses have been...

Designer Descemet Membranes Containing PDLLA and Functionalized Gelatins as Corneal Endothelial Scaffold.

Jul 02, 2020

Corneal blindness is the fourth leading cause of visual impairment. Of specific interest is blindness due to a dysfunctional corneal endothelium which can only be treated by transplanting healthy tiss...

Analysis of tear inflammatory molecules and clinical correlations in evaporative dry eye disease caused by meibomian gland dysfunction.

Jul 02, 2020

To compare the levels of inflammatory molecules in tear samples between patients with meibomian gland dysfunction (MGD)-related evaporative dry eye (EDE) and healthy subjects and to analyze the correl...

The Effect of Therapeutic Meibomian Glands Expression on Evaporative Dry Eye: A Prospective Randomized Controlled Trial.

Jul 02, 2020

To determine the clinical benefits of Meibomian gland expression therapy for the treatment of dry-eye disease caused by Meibomian gland dysfunction (MGD). : In a prospective randomized controlled doub...

Preclinical development of artificial tears based on an extract of Artemia salina containing dinucleotides in rabbits.

Jul 02, 2020

To evaluate the preclinical efficacy of eye drops based on an extract of Artemia salina on the ocular surface of rabbits. Tear secretion, tear break-up time and corneal staining were measured.A precli...

Prevalence and incidence of visual impairment in patients with proliferative diabetic retinopathy in India.

Jul 02, 2020

To provide the real-world outcomes of people with proliferative diabetic retinopathy (PDR) in India and highlight opportunities for improvement of their disease status and to evaluate their visual acu...

Prevalence and causes of bilateral visual impairment in rural areas of Tianjin, China - The Tianjin Eye Study.

Jul 02, 2020

To estimate the prevalence, causes and risk factors of bilateral visual impairment in rural areas of Tianjin, China.A large population-based, cross-sectional study. A stratified random cluster samplin...

Pathogenic role of human C-reactive protein in diabetic retinopathy.

Jul 02, 2020

Elevated blood levels of C-reactive protein (CRP) are associated with both type 1 and type 2 diabetes and diabetic complications, such as diabetic retinopathy (DR). However, its pathogenic role in DR ...

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