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Ophthalmology General

The retinal tyrosine kinome of diabetic Akimba mice highlights potential for specific SRC family kinase inhibition in retinal vascular disease.

Jun 29, 2020

Although anti-VEGF therapies have radically changed clinical practice, there is still an urgent demand for novel, integrative approaches for sight-threatening retinal vascular diseases. As we hypothes...

Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy.

Jun 29, 2020

To compare widefield swept-source optical coherence tomography angiography (WF SS-OCTA) with ultra-widefield colour fundus photography (UWF CFP) and fluorescein angiography (UWF FA) for detecting diab...

An open-source data set of anti-VEGF therapy in diabetic macular oedema patients over 4 years and their visual acuity outcomes.

Jun 29, 2020

The objective of this paper is to evaluate visual acuity (VA) outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) in diabetic macular oedema (DMO).In this retrospective cohort stud...

Goniowash: a new surgical approach combined with cataract surgery to lower intraocular pressure in pseudoexfoliation syndrome.

Jun 29, 2020

Pseudoexfoliation syndrome is common in elderly patients and is associated with intraocular pressure elevation. Goniowash is a novel surgical technique to remove pseudoexfoliation material from the ir...

Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retina pigment epithelium.

Jun 29, 2020

Juvenile neuronal ceroid lipofuscinosis (JNCL, aka. juvenile Batten disease or CLN3 disease) is a lysosomal storage disease characterized by progressive blindness, seizures, cognitive and motor failur...

Effect of late-onset blindness on cervical vestibular evoked myogenic potentials.

Jun 29, 2020

Approximately 1.3 billion people worldwide have vision impairment. The aim of the present study was to investigate the influence of Late-Onset blindness on cervical vestibular evoked myogenic potentia...

The control of conjunctival fibrosis as a paradigm for the prevention of ocular fibrosis-related blindness. "Fibrosis has many friends".

Jun 29, 2020

The processes involved in ocular fibrosis after disease or ocular tissue injury, including surgery play an important part in the development or failure of treatment of most blinding diseases. Ocular f...

The complication trends of adult spinal deformity surgery in Japan - The Japanese Scoliosis Society Morbidity and Mortality survey from 2012 to 2017.

Jun 29, 2020

The Japanese Scoliosis Society Morbidity & Mortality Committee performed a longitudinal nationwide complication survey of spinal deformity surgery from 2012 to 2017. The present study aimed to ana...

Gender Gap in Ophthalmology Conference Speakers

Jun 28, 2020

“Although the rates of women in medicine and ophthalmology are increasing, a gender gap still exists in senior positions, such as senior faculty, chairs of academic programs, and deans of medical sc...

Mycoplasma Pneumoniae Induced Rash and Mucositis (MIRM): A Longitudinal Perspective and Proposed Management Criteria.

Jun 25, 2020

To evaluate the natural history and ophthalmologic morbidity of Mycoplasma pneumoniae induced rash and mucositis (MIRM) and propose a treatment algorithm.Retrospective, interventional case series METH...

Dose-response and normal tissue complication probabilities after proton therapy for choroidal melanomas.

Jun 25, 2020

Normal tissue complication probability (NTCP) models could aid the understanding of dose-dependence of radiation-induced toxicities after eye-preserving radiotherapy of choroidal melanomas. We perform...

Clinical manifestation and risk factors associated with remission in patients with filamentary keratitis.

Jun 25, 2020

This study investigated the clinical manifestation and risk factors associated with remission in filamentary keratitis.Retrospective, interventional, comparative case series.We retrospectively reviewe...

Macular and Peripapillary OCTA Metrics Predict Progression in Diabetic Retinopathy: A Sub-analysis of TIME-2b Study Data.

Jun 25, 2020

To identify optical coherence tomography angiography (OCTA) derived vessel metrics of the macula and optic nerve head (ONH) that predict diabetic retinopathy (DR) disease progression.Secondary analysi...

A robust method for the automatic location of the optic disc and the fovea in fundus images.

Jun 25, 2020

The location of the optic disc (OD) and the fovea is usually crucial in automatic screening systems for diabetic retinopathy. Previous methods aimed at their location often fail when these structures ...

Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment.

Jun 25, 2020

Synaptic neurodegeneration of retinal ganglion cells (RGCs) is the earliest event in the pathogenesis of diabetic retinopathy. Our previous study proposed that impairment of mitochondrial trafficking ...

Postoperative complications in Medicare beneficiaries following endothelial keratoplasty (EK) surgery.

Jun 25, 2020

To determine national-level incidence rates of major postoperative complications following EK procedures, and to stratify these rates based on EK indications over an 8-year period using Medicare claim...

Intraocular Pressure Changes and VEGF Inhibitor Use in Various Retinal Diseases: Long-Term Outcomes in Routine Clinical Practice: Data from the Fight Retinal Blindness! Registry.

Jun 25, 2020

To report long-term changes in intraocular pressure (IOP) in eyes receiving vascular endothelial growth factor (VEGF) inhibitors for various retinal conditions over 12- and 24-months in routine clinic...

Nutraceuticals for dry age-related macular degeneration: a case report based on novel pathogenic and morphological insights.

Jun 25, 2020

Age-related macular degeneration represents the main retinal disorder leading to irreversible blindness in people over the age of 50 in the Western World. Here we describe a case report, which suggest...

Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract-based spatial statistics study.

Jun 22, 2020

Visual deprivation can lead to abnormal and plastic changes in the brain's visual system and other systems. Although the secondary changes of gray matter in patients have been well studied, the study ...

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity.

Jun 22, 2020

In systemic sclerosis (SSc) patients, dry eye syndrome (DES) is the most frequent ocular feature. The aim of this study was to investigate ocular DES-related SSc patients and to establish any correlat...

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