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Ophthalmology General

Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment.

Jun 25, 2020

Synaptic neurodegeneration of retinal ganglion cells (RGCs) is the earliest event in the pathogenesis of diabetic retinopathy. Our previous study proposed that impairment of mitochondrial trafficking ...

Postoperative complications in Medicare beneficiaries following endothelial keratoplasty (EK) surgery.

Jun 25, 2020

To determine national-level incidence rates of major postoperative complications following EK procedures, and to stratify these rates based on EK indications over an 8-year period using Medicare claim...

Intraocular Pressure Changes and VEGF Inhibitor Use in Various Retinal Diseases: Long-Term Outcomes in Routine Clinical Practice: Data from the Fight Retinal Blindness! Registry.

Jun 25, 2020

To report long-term changes in intraocular pressure (IOP) in eyes receiving vascular endothelial growth factor (VEGF) inhibitors for various retinal conditions over 12- and 24-months in routine clinic...

Nutraceuticals for dry age-related macular degeneration: a case report based on novel pathogenic and morphological insights.

Jun 25, 2020

Age-related macular degeneration represents the main retinal disorder leading to irreversible blindness in people over the age of 50 in the Western World. Here we describe a case report, which suggest...

Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract-based spatial statistics study.

Jun 22, 2020

Visual deprivation can lead to abnormal and plastic changes in the brain's visual system and other systems. Although the secondary changes of gray matter in patients have been well studied, the study ...

Dry Eye in Systemic Sclerosis Patients: Novel Methods to Monitor Disease Activity.

Jun 22, 2020

In systemic sclerosis (SSc) patients, dry eye syndrome (DES) is the most frequent ocular feature. The aim of this study was to investigate ocular DES-related SSc patients and to establish any correlat...

Lipid Conformational Order and the Etiology of Cataract and Dry Eye.

Jun 22, 2020

     Lens and tear film lipids are as unique as the systems they reside in. The major lipid of the human lens is dihydrosphingomylein, found in quantity only in the lens. The lens contains a chole...

Interactions of polar lipids with cholesteryl ester multilayers elucidate tear film lipid layer structure.

Jun 22, 2020

The tear film lipid layer (TFLL) covers the tear film, stabilizing it and providing a protective barrier against the environment. The TFLL is divided into polar and non-polar sublayers, but the interp...

Comparison of inflammatory cytokines levels in the aqueous humor with diabetic retinopathy.

Jun 22, 2020

Evidence has accumulated suggesting that various inflammatory cytokines are involved in the progress of diabetic retinopathy (DR), but there are few studies concerning the relationship between individ...

Individualizing Therapy for Neovascular Age-Related Macular Degeneration with Aflibercept (VITAL): A Two-Year Prospective, Interventional Single-Centre Trial.

Jun 22, 2020

To report the mean change in Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) and reading performance (reading acuity and maximum reading speed (MRS) using the MN...

Diabetic Retinopathy Screening with Automated Retinal Image Analysis in a Primary Care Setting Improves Adherence to Ophthalmic Care.

Jun 22, 2020

Retinal screening examinations can prevent vision loss from diabetes, but are costly and highly underutilized. We hypothesized that artificial intelligence-assisted non-mydriatic point-of-care screeni...

Cataract surgery in Kinshasa - Is there a place for "Monovision"?

Jun 22, 2020

Monovision is a method of correcting presbyopia where one eye is focused for far and the other for near vision. It is a simple, cost effective approach to overcome the loss of accommodation with age a...

Evaluation of the genetic association between early-onset primary angle-closure glaucoma and retinitis pigmentosa.

Jun 22, 2020

Primary angle-closure glaucoma (PACG) and retinitis pigmentosa (RP) can co-occur, but the mechanism of their association is not yet established. The purpose of this study was to investigate the differ...

Personalising surgical treatments for glaucoma patients.

Jun 22, 2020

Surgical treatments for glaucoma have relied for decades on traditional filtering surgery such as trabeculectomy and, in more challenging cases, tubes. Antifibrotics were introduced to improve surgica...

Use of Optical Coherence Tomography Retinal Thickness Deviation Map for Hydroxychloroquine Retinopathy Screening.

Jun 22, 2020

To investigate the use of a retinal thickness deviation map generated from swept-source optical coherence tomography (SS-OCT) images for hydroxychloroquine (HCQ) retinopathy screening.Retrospective co...

Fully automated detection, segmentation, and analysis of in vivo RPE single cells.

Jun 22, 2020

To develop a fully automated method of retinal pigmented epithelium (RPE) cells detection, segmentation and analysis based on in vivo cellular resolution images obtained with the transscleral optical ...

Reporting of Race and Ethnicity in the Ophthalmology Literature in 2019.

Jun 22, 2020

The description of racial and ethnic data in human trials is relatively unregulated, leading to potential confusion with and inconsistent reporting of these data.To determine the frequency and use of ...

Cord Blood Platelet Rich Plasma Derivatives for Clinical Applications in Non-transfusion Medicine.

Jun 18, 2020

Cord blood platelet rich plasma (CB-PRP) derivatives have been investigated as potential therapeutic agents for the treatment of diverse conditions including ocular surface disease and skin ulcers. We...

Carboxymethyl Cellulose-Coated Tacrolimus Nonspherical Microcrystals for Improved Therapeutic Efficacy of Dry Eye.

Jun 18, 2020

Dry eye (DE) is a highly prevalent ocular surface disease which affects the quality of life and results in low working efficiency. Frequent instillation is required due to low bioavailability of conve...

A novel botanical formula improves eye fatigue and dry eye: a randomized, double-blind, placebo-controlled study.

Jun 18, 2020

With the frequent use of video display units, eye fatigue is becoming more common globally. An alternative nutritional strategy is needed to prevent the aggravation of eye fatigue symptoms.The objecti...

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